Protein Alignment CG3216 and adcy1b

DIOPT Version :10

• Sequence 1: NP_726013.2
• Gene: CG3216 / 37376
• FlyBaseID: FBgn0034568
• Length: 1161
• Species: Drosophila melanogaster
• Sequence 2: XP_073776301.1
• Gene: adcy1b / 569499
• ZFINID: ZDB-GENE-100805-1
• Length: 1121
• Species: Danio rerio
• Alignment Length: 1241
• Identity: 256/1241 - (20%)
• Similarity: 430/1241 - (34%)
• Gaps: 408/1241 - (32%)

  Fly    75 RYTEVGEMGSTMRVYNVGVLMASHLDSPFDLERCGPAVDLALDEINKVFLKPHNITLLKKKGSYP 139
            ||....|..:|::..:|.:|::..| |..:|...|..:.:|                   :||:|
Zfish    40 RYRLKLEQTATLKALSVLILLSCSL-SLLELLLSGTGLSVA-------------------QGSHP 84

  Fly   140 SCSGARAPGLAADMYFQDDV-------------------IAFIGPACAFALEPVARLA------- 178
            ..|     .|...::...:|                   ..|..|.|  .|..|:|.|
Zfish    85 VHS-----VLFISLFIVTNVQYLQVTQLQQIAHLSLLFGFTFAVPCC--PLPQVSRAAGPEQGVW 142

  Fly   179 --------AYWNKPIITGM----GDQPPSSEGELTVTSGILGRIHKWKN--ENTGMFKDKSKYPT 229
                    ||...|:.||:    |...|.:...:|.::........|::  .||
Zfish   143 PLLLLTFVAYCLLPVRTGLALLFGLLLPLAHTLITASALPDNTQRLWRSLVANT----------- 196

  Fly   230 LTRMSYCQCRLILVFASVIRQFNWNHVALLVDRSELFSWTVGKN-LEYGLRQEGLLSFVKELNGN 293
                        |:|..|  ..:...|.:|.:|::..::...:| :|..||.|           :
Zfish   197 ------------LLFTGV--NVSGLFVRILTERAQRKAFLQARNCIEERLRME-----------D 236

  Fly   294 EEEVYENYLKDASMYARVVILSVRGVLVR-------KFMLAAHSLGMTNGEWVFLDVEIFQS--- 348
            |.|..|..|  .|:..|.|.:.::...::       |..:..|.    |...:|.|:..|.|
Zfish   237 ENEKQERLL--MSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHD----NVSILFADIVGFTSLAS 295

  Fly   349 ------------EYWGDKGWEMKDEHDAKARKAYEALLRVSLLQPTSPKFQDFADNVRENAL--Y 399
                        |.:|.......:.|..:.:...:....||.|  |.|| .|.|....|..|  .
Zfish   296 QCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGL--TQPK-TDHAHCCVEMGLDMI 357

  Fly   400 DYNYTFGEGEEV--NFFIGAFYDGVYLLG-MALNE-------------TLTEGGDIRDGVNITRR 448
            |...:..|..||  |..:| .:.|..|.| :.|.:             .:.|.|.:...|:|||
Zfish   358 DTITSVAEATEVDLNMRVG-LHTGRVLCGVLGLRKWQYDVWSNDVTLANMMEAGGLPGKVHITR- 420

  Fly   449 MWNRTFEGITGHVRIDDNGDRDADYSILDLDPINGKFSVVAHYSGVHKVYSAVHGKKIHWPGGRE 513
               .|.|.:.|...::....|:....:|..| |...|.|.:            |.:|| :||
Zfish   421 ---STLECLNGDYEVEPGNGRERHAFLLKHD-IETFFIVPS------------HRRKI-FPG--- 465

  Fly   514 EPPPDVPPCGFLGNSTDCVGNFSTIMYSVFGLLLFLGLVFLVICLLQKQMKLSKELNNMSWRVRP 578
            ....|:.|...:        .|.|:.|.         ||.|:.|  :|..|.....:|:
Zfish   466 LILSDIKPAKKM--------KFKTVCYL---------LVQLMHC--RKMFKAEIPFSNV------ 505

  Fly   579 DDVLIEMGGMFGSKGGLQRLDVENISLQQFGIHSGRASIASFTSLPPQVYTTIGQFKGERVAIKK 643
                  |....|.|..:.|...|.       :.:...:.||.....|.  |.:.::....:..::
Zfish   506 ------MNCEDGDKRRVLRSAPEK-------LRNRTPTTASAPQSSPG--TRVNRYINRLIEARQ 555

  Fly   644 VNVKKVDLTPQLLWEIKQARDVSHE------NTVRFVGACI---------------DLPRPT-VL 686
            ......||....|    ..||...|      |...|.||.:               .:|:.| ||
Zfish   556 TESDTADLNYLTL----MYRDSERERRYHQLNDEYFTGAVVLSLLLVVLLGFLYLLIIPQGTVVL 616

  Fly   687 ILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHG-----KLRSCNCLID 746
            :|..:|                        |..:|..:.|||.:.|....     ::|:..|:..
Zfish   617 VLLVFC------------------------ICFLVVCIMYLHITRVQCFPGCLTIQIRTALCVFI 657

  Fly   747 GRFVLKISD---FGLRTLTTPSDFVR-----------------------------------DQNY 773
            ...:..::.   .|......||:..|                                   ....
Zfish   658 VLLIYAVAQACVVGCMPWLWPSNSTRSIVIIDAAAGLNRTMAELPCAGAQYAFLCCMLGTLSMAL 722

  Fly   774 YLKLLWIAPELLPLTTIPGCCPATQRGDVYSFGIILEEIVNRGGPYQEARQQMDVHTILHKVRQC 838
            :|::.|| |:::.|..:           :..:..|||                     |...|:.
Zfish   723 FLRVSWI-PKMILLLLL-----------LVLYITILE---------------------LSGFRRA 754

  Fly   839 NGFRPLIRERECPPDLLELMEKCWADNQEERPTFST-IRSNIRTIMKGFCENLMDDLLNRME-QY 901
            :|: .|:..|...| ||.|:            .||| :..:.|.:          ||..|:: .:
Zfish   755 SGW-ALLSVRGLEP-LLSLL------------LFSTAVALHSRQL----------DLKLRLDFLW 795

  Fly   902 ANNLESLVEEK--TRQLSLEKQRTEELLYQILPRPVAQQLMAG---DLVEPEE--------FSSV 953
            |...|   ||:  ..::.|:.:|   :|:.:||..|||..:..   ::|...|        ::.|
Zfish   796 ATQAE---EERDGMEKVKLDNKR---ILFNLLPVHVAQHFLLSNPRNMVRSSEHQDLYYQSYAQV 854

  Fly   954 TIYFSDIVGFT----ELCARSSPMDVVNFLNDLYSTFDRIIG---FYDVYKVETIGDAYLVVSGL 1011
            .:.|:.|..|.    ||...:..::.:..||::.:.||.::.   :.|:.|::|||..|:...||
Zfish   855 GVLFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMDKECYKDIEKIKTIGSTYMSAVGL 919

  Fly  1012 PEPNGDK-------HAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPH 1069
            ....|.|       |...||..|:::...:...|.:...::  .:|:|::.|.|.|||:|.:.|.
Zfish   920 VPTIGTKAKKSTATHLSTIADFAIEMFDVLDEINYQSYNDF--VLRVGINVGPVVAGVIGARRPQ 982

  Fly  1070 YCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVELKGKGTVTTYWLNSTSE 1134
            |.::|:|||.||||:|||.||||.|:.....:|.  ..:.:..||:|.:||||.:.||:|    |
Zfish   983 YDIWGNTVNVASRMDSTGVPGKIQVTEDVYRLLQ--NNYDLMCRGNVSVKGKGQMLTYFL----E 1041

  Fly  1135 GEARPP 1140
            |:|:.|
Zfish  1042 GKAQDP 1047

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_GC-like	90..501	CDD:380575	94/491 (19%)
		Protein Kinases, catalytic domain	616..885	CDD:473864	53/334 (16%)
		HNOBA	<891..939	CDD:462234	15/50 (30%)
		CYCc	918..1109	CDD:214485	62/215 (29%)
adcy1b	XP_073776301.1	None