DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3216 and npr3

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	XP_005165413.1	Gene:	npr3 / 569395	ZFINID:	ZDB-GENE-060531-91	Length:	503	Species:	Danio rerio

Alignment Length:	479	Identity:	139/479 - (29%)
Similarity:	216/479 - (45%)	Gaps:	81/479 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 DEINKVFLKPHNIT-LLKKKGSYPSCSGARAPGLAADMY--------FQDDVIAF---------- 162
            |.|..:.:.|.|.| |......:|:...|:.....||.|        |::.....
Zfish    26 DNIEVMVMLPRNNTYLFSYTRVFPAIEYAKKALREADAYAGLRFNVRFENSACGMDALYALVDRQ 90

  Fly   163 --------IGPACAFALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTSGILGRIHKWKNENTG 219
                    :||.|.:|...|.|:|::||.|:|         |.|.|.                ||
Zfish    91 KDERPDLVLGPVCEYAASSVTRVASHWNIPVI---------SAGALA----------------TG 130

  Fly   220 MFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNWNHVALLV--DRSELFSWTVGKNLEYGLRQEG 282
            ......:|..|||::....::...|.::...|.|....|:.  |:.|       :|..:.:  ||
Zfish   131 FNSKTPEYSHLTRIAPTYLKMAETFQAIFGHFGWRTAYLIYDDDKDE-------RNCYFTM--EG 186

  Fly   283 LLSFVKE---------LNGNEEEVYENYLKDASMYARVVILSVRGVLVRKFMLAAHSLGMTNGEW 338
            :.:.:.|         ||.|||.|..:.:..:...:.|||:..:..:||..|||||...:|:...
Zfish   187 VFTVLSEYHISTDFAVLNSNEERVDPDGIITSVYGSEVVIMCSKADIVRDLMLAAHRRKLTSDSH 251

  Fly   339 VFLDVEIFQSEYWGDKGWEMKDEHDAKARKAYEALLRVSLLQPTSPKFQDFADNVRENALYDYNY 403
            :|.::|:|.|..:||..|..:|::|.:||.||..|..|:||:.|.|:|:||:..::: :|...|.
Zfish   252 IFFNIELFNSSSYGDGSWRRRDKYDDEARAAYSFLNTVTLLRSTKPEFEDFSIEMKK-SLQQSNI 315

  Fly   404 TFGEG-EEVNFFIGAFYDGVYLLGMALNETLTEGGDIRDGVNITRRMWNRTFEGITGHVRIDDNG 467
            ...|. ..||.|:..|:|.:.|..:||.|..::|...::|:.||..|||||||||.|.|.:|.||
Zfish   316 PICEDCSAVNMFMEGFHDALLLYAIALREVKSKGLTKKNGLEITHSMWNRTFEGIAGQVSLDANG 380

  Fly   468 DRDADYSILDL-DPINGKFSVVAHYSGVHKVYSAVHGKKIHWPGGREEPPPDV--PPCGFLGNST 529
            ||:.|:|::.: ||.:||...|.:|.|.:..:..:.|.|..|...|..|||..  |..|.||.|.
Zfish   381 DRNGDFSVVRMTDPESGKHETVMNYFGTNGSFQILPGFKREWFSLRTIPPPKPLDPSSGGLGVSA 445

  Fly   530 DCVGNFSTIMYSVFGLLLFLGLVF 553
            ..    ..|:..:.|..|.|...|
Zfish   446 VT----GIIVGGILGTALLLAFYF 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	122/418 (29%)
		ANF_receptor	107..479	CDD:279440	115/401 (29%)
		PKc_like	616..885	CDD:304357
		TyrKc	627..877	CDD:197581
		HNOBA	<882..939	CDD:285003
		CYCc	918..1109	CDD:214485
		Guanylate_cyc	945..1131	CDD:278633
npr3	XP_005165413.1	Periplasmic_Binding_Protein_Type_1	29..416	CDD:299141	120/421 (29%)
		ANF_receptor	46..389	CDD:279440	109/377 (29%)
		TM_EphA1	436..468	CDD:214014	10/34 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810