Protein Alignment CG3216 and gucy2cb

DIOPT Version :9

• Sequence 1: NP_726013.2
• Gene: CG3216 / 37376
• FlyBaseID: FBgn0034568
• Length: 1161
• Species: Drosophila melanogaster
• Sequence 2: XP_021329920.1
• Gene: gucy2cb / 568219
• ZFINID: ZDB-GENE-130531-31
• Length: 1071
• Species: Danio rerio
• Alignment Length: 1142
• Identity: 337/1142 - (29%)
• Similarity: 519/1142 - (45%)
• Gaps: 261/1142 - (22%)

  Fly    91 VGVLMASHLDSPFDLERCGPAVDLALD---EIN-------KVFLKPHNITLLKKKG-SYPSCSGA 144
            :.|::.....||:.:....|||..|::   |||       .|..:.......:|.| |..:|.|.
Zfish    33 INVVLLDDDVSPWSINFVKPAVMRAVESDSEINFKDGVNLSVSFRGFQTIYYQKTGCSSSACEGV 97

  Fly   145 RAPGLAADMYFQDDVIAFIGPACAFALEPVA--RLAAYWNKPIIT----GMGDQ---------PP 194
            ......|:.  .::..|.:||.|.:|...:|  .:....|.|||:    |:...         ||
Zfish    98 EILNDLANA--GEEGCALLGPTCTYATFQMADLEIGLNLNMPIISAGSFGLSCDLKRDLTRLLPP 160

  Fly   195 SSEGELTVTSGILG--RIH-----KWKNENTGMFKDKSKYPTLTRMSYCQCRLILV----FASVI 248
            :.:    ::|..:.  :.|     ||  |...::|.    |..|...:.....:.|    |:..:
Zfish   161 ARK----ISSFFINFWKFHDPVKPKW--ETAYLYKK----PDNTEDCFWYINALEVSNGGFSPSL 215

  Fly   249 RQFNWNHVALLVDRSELFSWTVGKNLEYGLRQEGLLSFVKELNGNEEEVYENYLKDASMYARVVI 313
            ::     :.::.::.:|.......|.|..|       |:  |.|..:::.:  ||:
Zfish   216 QE-----IEVIRNKEDLTKAMAKHNRESNL-------FI--LCGTPDDIMD--LKN--------- 255

  Fly   314 LSVRGVLVRKFMLAAHSLGMT--NGEWVFLDVEIFQSEYWGDKGWEMKDEHDAKARKAYEALLRV 376
                              |.|  :.|..||.::::...|:       |.:.:...|..      :
Zfish   256 ------------------GTTDYDSEIAFLLIDLYNDIYY-------KGQSNTFMRNV------L 289

  Fly   377 SLLQPTSPKFQDFADNVRENALYDYNYTFGEGEEVNFFIGAFYDGVYLLGMALNETLTEGG-DIR 440
            .|..|.:.|:.  .|....|.:.||             |.|::|.|.|.|..:......|. ||:
Zfish   290 VLTMPNTRKYT--IDTSGNNTMNDY-------------IAAYHDAVLLFGQVMRNIQKSGSLDIQ 339

  Fly   441 DGVNITRRMW-NRTFEGITGHVRIDDNGDRDADYSILDLDPINGKFSVVAHY-SGVHKVYSAVHG 503
            |..:::...: |.:|.||.|..::|.:||||..:|::..:. |.:::::..: :..:|.......
Zfish   340 DMESVSMNYFRNVSFTGIAGEYQLDQHGDRDLMFSLIYTNN-NNQYNILYQFNTSNNKTGLKDSS 403

  Fly   504 KKIHWPGGREEPPPDVPPCGFLGNSTDCVGNFSTIMYSVFGLLLFLGLVFL-------------- 554
            ....|   :...|.|.|..|.     ..:.....::.:|.|::..|..:|.
Zfish   404 PSFIW---QSRLPNDSPSKGL-----SVIEIIVIVLCTVIGIMGTLAFIFYWQNRYYHHMQKRWS 460

  Fly   555 -VICLLQKQMKLSKELNNMSWRVRPDDV-----LIEMGGMFGSKGGLQRLDVENISLQQFGIHSG 613
             :...|...::|: |.|.:|.::..|..     ::...          |.|.:.:.|::|.:..|
Zfish   461 HISSQLITPLELN-EWNMISLKIEEDSTENSTYILRRA----------RYDKKIVILKEFRLTDG 514

  Fly   614 RASIASFTSLPPQVYTTIGQFKGERVAIKKVNVKKVDLTPQLLWEIKQARDVSHENTVRFVGACI 678
                 |||               |:..|:...:.|:|                :.|..:|.|
Zfish   515 -----SFT---------------EKQRIELNTLLKID----------------YCNLTKFYG--- 540

  Fly   679 DLPRPTVLI------LTEYCSRGSLKDVLEN-----EAIELDWNFRMSLIHDIVKGMNYLHNSDV 732
                 ||..      :.||..||||:.||::     |...:||.|::|:::||.|||:|||.|::
Zfish   541 -----TVKFDNEYFGVFEYGERGSLRYVLDDKISYPEETFMDWQFKISVMYDIAKGMSYLHTSNI 600

  Fly   733 AAHGKLRSCNCLIDGRFVLKISDFGLRTLTTPSDFVRDQNYYLKLLWIAPELLPLTTIPGCCPAT 797
            |.||:|:|.||::|.|.|:||:|||..|:.:||:.          ||.|||.|   ..||   .:
Zfish   601 AVHGRLKSTNCVVDNRMVVKIADFGFNTIVSPSED----------LWTAPEHL---RKPG---IS 649

  Fly   798 QRGDVYSFGIILEEIVNRGGPY----------QEARQQMDVHTILHKVRQCNGFRPLIR---ERE 849
            |:||||||.||.:||:.|...:          :.||.|....|        :.|||.:.   ..|
Zfish   650 QKGDVYSFAIISQEIMMRKCTFYTNTCSDRAEKLARVQYPSTT--------SFFRPDLNFESTSE 706

  Fly   850 CPPDLLELMEKCWADNQEERPTFSTIRSNIRTIM---KGFCENLMDDLLNRMEQYANNLESLVEE 911
            ...::..|:..||.::.:.||.|..|...:..|:   ....|:.|::|:.|::.|:.|||.||||
Zfish   707 SEEEVCMLIRNCWDEDPDRRPDFKKIEIALWKIVSRDNQEHESYMENLIRRLQMYSRNLERLVEE 771

  Fly   912 KTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVV 976
            :|.....|:.|.:.|.:.:||.||.:.|.....||||.|..||||||||||||.||..|:||:||
Zfish   772 RTALYKAERDRADCLNFMLLPGPVVRSLKETGKVEPELFDEVTIYFSDIVGFTTLCHFSTPMEVV 836

  Fly   977 NFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLRH 1041
            :.|||:|..||.|:..:||||||||||||:||||||..||::||::|.|||||||..:.:..|.|
Zfish   837 DMLNDIYKNFDSILDNHDVYKVETIGDAYMVVSGLPRRNGNRHAKDICLMALDILAFMGTIQLSH 901

  Fly  1042 KPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFG 1106
            .|...:.||||:|||...|||||.|||.||||||||||||||||||.|.:||||.:|..||.:..
Zfish   902 LPGIPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSQSTINILQRTD 966

  Fly  1107 -TFQMEQRGDVELKGKGTVTTYWLNSTSEGEARPPTP 1142
             .|:.|:||:..|||||...||||...:......|||
Zfish   967 CKFEYEERGETFLKGKGKEMTYWLTGVTGENYNLPTP 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	86/446 (19%)
		ANF_receptor	107..479	CDD:279440	82/412 (20%)
		PKc_like	616..885	CDD:304357	88/295 (30%)
		TyrKc	627..877	CDD:197581	84/273 (31%)
		HNOBA	<882..939	CDD:285003	21/59 (36%)
		CYCc	918..1109	CDD:214485	113/191 (59%)
		Guanylate_cyc	945..1131	CDD:278633	118/186 (63%)
gucy2cb	XP_021329920.1	Periplasmic_Binding_Protein_Type_1	33..408	CDD:324556	87/458 (19%)
		PKc_like	471..741	CDD:328722	98/348 (28%)
		CYCc	778..970	CDD:214485	113/191 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920