DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and npr1a

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_001038402.1	Gene:	npr1a / 560653	ZFINID:	ZDB-GENE-060503-539	Length:	1067	Species:	Danio rerio

Alignment Length:	1120	Identity:	452/1120 - (40%)
Similarity:	650/1120 - (58%)	Gaps:	115/1120 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LAGLNASDAGLEQRMYERSRESKSTQLSRYTEVGEMGSTMRVYNVGVLMASHLDSPFDLERCGPA 111
            |:|::.....||. :.|...:|.|...|      :...|:.|    :|...:.:.|:...|.|||
Zfish    17 LSGVSFGVVELEP-VPENQPQSPSAHAS------QKNITLAV----ILPLHNTEYPWAWPRVGPA 70

  Fly   112 VDLALDEINK--VFLKPHNITLL-----KKKGSYPSCSGARAPGLAADMYFQDDVIAFIGPACAF 169
            :..||:::|.  ..|..:::.|:     .|:|   .||.:.||.:|.|:.|..:..|||||.|.:
Zfish    71 LYWALEKVNSDPNLLAGYHLQLVFNSSENKEG---LCSDSVAPLVAVDLKFSYNPWAFIGPGCDY 132

  Fly   170 ALEPVARLAAYWNKPIIT----GMGDQPPSSEGELTVTSGILGRIHKWKNENTGMFKDKSKYPTL 230
            :..||||...:|..|:||    .:|....||     :|:  :|..||    ..|.|        :
Zfish   133 SSSPVARFTTHWEVPMITSGARALGFNLYSS-----ITN--IGPTHK----KLGEF--------V 178

  Fly   231 TRMSYCQCRLILVFASVIRQFNWNHVALLV-------DRSELFSWTVGKNLEYGLRQEGLLSFVK 288
            .||.              |.|.|:..|:|:       ||...|: ..|...:  :|::.:.:...
Zfish   179 LRMH--------------RHFGWDKHAMLMFNDNKNDDRPCYFA-VEGPYTQ--MREDNITADDL 226

  Fly   289 ELNGNEEEV-YENYLKDASMYARVVILSVRGVLVRKFMLAAHSLGMTNGEWVFLDVEIF----QS 348
            ..|.:||.: |:..|:|.|..||||.:..:....||.|:.....|....|:.|..:::|    ||
Zfish   227 VFNEDEEPLRYDELLRDISHKARVVYVCCKWETFRKLMVEFWRQGFPQEEYAFFFIDLFGRSLQS 291

  Fly   349 EYWGDKGWEMKDEHDAKARKAYEALLRVSLLQPTSPKFQDFADNVRENALYDYNYTFGEGEEVNF 413
            .  ..:.|...|..|..|::|::::..::..:|.:|:::||...::..|:..:|:.. |...:|.
Zfish   292 H--PARPWARGDADDNAAKEAFKSVKILTYREPQNPEYKDFVSKLKTEAMDMFNFNV-EDSLMNL 353

  Fly   414 FIGAFYDGVYLLGMALNETLTEGGDIRDGVNITRRMWNRTFEGITGHVRIDDNGDRDADYSILDL 478
            ..|:|:|||.|...|||:|:...|....|..:.:||||||:.|:||.|::|:||||:.|:::.|:
Zfish   354 ISGSFHDGVMLYSHALNDTMDRSGSRPPGDVVNKRMWNRTYHGVTGLVQLDENGDREIDFALWDM 418

  Fly   479 -DPINGKFSVVAHYSGVHKVYSAVHGKKIHWPGGREEPPPDVPPCGFLGNSTDCVGNFSTI--MY 540
             |...|.:.:|:.|:|..|......|.|:||..||  ||||:|.|||..::..|:....|:  |.
Zfish   419 TDTKTGDYQIVSVYNGSQKQMILEPGMKVHWLKGR--PPPDIPECGFKNDNPACLAKTVTMHQMI 481

  Fly   541 SVFGLLLFLGLVFLVICLLQKQMKLSKELNNMSWRVRPDDVLIEMGGMFGSKGGLQRLDVE-NIS 604
            |:....:|: ::..|...:.:::||..||....|||..:|:     .|..::..|:|...: .||
Zfish   482 SIVVCFIFI-IIVTVTVFIYRKLKLENELTAQLWRVHWEDI-----QMSNTEKVLRRACSKLTIS 540

  Fly   605 LQQFGIHSGRASIASFTSLPPQVYTTIGQFKGERVAIKKVNVKKVDLTPQLLWEIKQARDVSHEN 669
            |:.....|......:|     |:|...|.:||...|||.||.|:::||.::|:|:|..|||.:|:
Zfish   541 LRGSNYGSLLTMDGNF-----QIYAKTGYYKGNITAIKYVNKKRIELTRKVLFELKHMRDVQNEH 600

  Fly   670 TVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAA 734
            ..||:|||||  .|.:.||||||.||||:|::|:|.|.|||.||.|||:||||||.:||||.:.:
Zfish   601 LTRFIGACID--PPNICILTEYCPRGSLQDLMESEGITLDWMFRYSLINDIVKGMAFLHNSVIVS 663

  Fly   735 HGKLRSCNCLIDGRFVLKISDFGLRTLTTPSDFVRDQN------YYLKLLWIAPELLPLTTIPGC 793
            ||.|:|.||::|.||||||:|:||.:      |.:|.|      :|.:.||.|||||.....|.|
Zfish   664 HGNLKSSNCVVDSRFVLKITDYGLES------FHKDSNLDDVHAFYARQLWTAPELLRADNPPAC 722

  Fly   794 CPATQRGDVYSFGIILEEIVNRGGPYQEARQQMDVHTILHKVRQCNGFRPLIRERECP----PDL 854
              .||:||||||||||:|:....|.:......:....|:.:|  ..|..|.:|...||    .::
Zfish   723 --GTQKGDVYSFGIILQELALLKGVFYLEGPCLSPKEIIERV--VEGRWPYLRPLLCPQSHSEEM 783

  Fly   855 LELMEKCWADNQEERPTFSTIRSNIRTIMKGFCENLMDDLLNRMEQYANNLESLVEEKTRQLSLE 919
            .:||.:||:::..|||.||.|:..:|....|:..|::|:||:||||||||||.||||:|:....|
Zfish   784 GQLMLRCWSEDVNERPDFSQIKVLLRKNNCGYGSNILDNLLSRMEQYANNLEELVEERTQAYHEE 848

  Fly   920 KQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYS 984
            |::.|.|||||||..||:||..|::|:.|.|.|||||||||||||.|.|.|:||:||..|||||:
Zfish   849 KRKAEALLYQILPHSVAEQLKRGEMVQAEAFDSVTIYFSDIVGFTALSAESTPMEVVTLLNDLYT 913

  Fly   985 TFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQI 1049
            .||.||..:||||||||||||:||||||..||..||||||.|:|.:|.||.||.:||:|..::::
Zfish   914 CFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLEAVHSFRIRHRPNLQLRL 978

  Fly  1050 RIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFGTFQMEQRG 1114
            |||:|||.|||||||.|||.||||||||||||||||.|:..|||||.||:|:|.:|..||:|.||
Zfish   979 RIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRG 1043

  Fly  1115 DVELKGKGTVTTYWL 1129
            |||:||||.:.||||
Zfish  1044 DVEMKGKGRMRTYWL 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	122/429 (28%)
		ANF_receptor	107..479	CDD:279440	115/395 (29%)
		PKc_like	616..885	CDD:304357	122/278 (44%)
		TyrKc	627..877	CDD:197581	119/259 (46%)
		HNOBA	<882..939	CDD:285003	32/56 (57%)
		CYCc	918..1109	CDD:214485	126/190 (66%)
		Guanylate_cyc	945..1131	CDD:278633	127/185 (69%)
npr1a	NP_001038402.1	PBP1_NPR_A	48..449	CDD:107380	127/446 (28%)
		ANF_receptor	66..421	CDD:279440	115/396 (29%)
		PK_GC-A_B	540..814	CDD:270944	125/290 (43%)
		TyrKc	554..808	CDD:197581	121/270 (45%)
		HNOBA	<823..868	CDD:285003	29/44 (66%)
		CYCc	847..1032	CDD:214485	124/184 (67%)
		Guanylate_cyc	874..1060	CDD:278633	127/185 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9792
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37367
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	1	1.000	-	-		FOG0002376
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.680