DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and si:ch211-132f19.7

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	XP_688903.4	Gene:	si:ch211-132f19.7 / 560410	ZFINID:	ZDB-GENE-130530-619	Length:	1183	Species:	Danio rerio

Alignment Length:	1337	Identity:	270/1337 - (20%)
Similarity:	447/1337 - (33%)	Gaps:	455/1337 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PNPRRNDITW--------------------------------DDLNKDISLDSTTSLAGLNASDA 55
            ||.:|..:.|                                ||:|:.|...:....||::...:
Zfish    22 PNLKRKQLMWQNAVRHIIDQRGMHHEGRAVNSRKIIVTDAYIDDINRQIRNKAARGNAGMHKRRS 86

  Fly    56 GLEQRMYERSRESKSTQLSRYTEVG-----EMGSTMRVYNVGVLMAS--HLDSPFDLE------- 106
            ...:....|.|.|..|:.|..:...     ..|||:|    |:.:.:  |.....|||
Zfish    87 SAARIHPFRERNSTCTRKSTESVTDADFFVSWGSTVR----GIFLPALHHKFKSHDLEHLYQQHS 147

  Fly   107 ----RCGPAVDLALDEINKVF-------LKPHNIT--------LLKKKGS-----YPSCSGARAP 147
                |....|...:|.:.|:.       |.|..:.        ||...|:     ..:|.|..:|
Zfish   148 SGQRRTSLVVTNVIDILTKLHIIFIYLALAPEMVDSQHGWLAGLLMALGAIICVLVLTCKGLMSP 212

  Fly   148 GLAADMYFQDDVIAFIGPACAFALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTSGILGRIHK 212
                      |.:.:.|             .|.|....:..:|                 |.::
Zfish   213 ----------DYLRYAG-------------LASWLSQTVQALG-----------------GLVY- 236

  Fly   213 WKNENTGMFKDKSKYPTLTRMS-YCQCRLILVFASVIRQFNWNHVALLVDRSELFSWT--VGKNL 274
                  |:..|:|.|...|..: |....|.|:: |:...|....:.|.||..:.::.|  |.|.|
Zfish   237 ------GLETDQSWYVLFTLFAIYTLLPLPLLW-SICMGFLTAALHLFVDTFKNYNDTAIVRKLL 294

  Fly   275 EYGLRQEGLLSFVKELNGNEEEVYENYLKDASMYARVVILSVRGV----------------LVRK 323
            ..||...|:         |...::.:||.|.:.  |...|..|..                ||..
Zfish   295 AKGLLYMGM---------NTAGLFIHYLSDRAQ--RQAFLETRRCIEGRVKMERENQRQERLVMS 348

  Fly   324 FMLAAHSLGMTNGEWVFLDVEIFQSEYWGDKGWEMKDEHDAKARKAYEALLRVSLLQPTSPKFQD 388
            .:....::.|. |:...||.|:...::......:.||               ||:|
Zfish   349 ILPRFIAMEMI-GDMTALDDELLPQQFHKTYFHQYKD---------------VSIL--------- 388

  Fly   389 FADNVRENALYDYNYTFGEGEEVNFFIGAFYDGVYLLGMALNETLTEGGDIRDGVNITRRMWNRT 453
            |||                           ..|...|.|.:
Zfish   389 FAD---------------------------IKGFTSLSMTM------------------------ 402

  Fly   454 FEGITGHVRIDDNGDRDADYSILDLDPINGKFSVVAHYSGVHKVYSAVHGKKIHWPGGREEPPPD 518
                            .|...:..|:.:.|:|..:|..:  |.:...:.|...:...|..||...
Zfish   403 ----------------PAQELVRTLNELFGRFDRLAEEN--HCMRIKILGDCYYCVSGVPEPQTA 449

  Fly   519 VPPCGFLGNSTDCVGNFSTIMYSVFGLLLFLGLVFL-VICLLQKQMKLSKELNNMSWRVRPDDVL 582
            ...|        ||.               :||..: .|..::|::|     .:|..|:.
Zfish   450 HARC--------CVE---------------MGLAMINTIRYVRKELK-----RDMDMRIG----- 481

  Fly   583 IEMGGMFGSKGGLQR---------LDVENISLQQFG----IHSGRASIASFTSLPPQVYTT---I 631
            |..|.:.....|||:         :||.|: |:..|    ||..||::.....    ||.|   .
Zfish   482 IHSGSVLCGVLGLQKWQFDVWSWDVDVANM-LEAGGIPGRIHISRATLDCLEG----VYETEEGR 541

  Fly   632 GQFKGERVAIKKVNVKKVDLTPQLLWEIKQARDVSHENT------------------VRFV-GAC 677
            |..:.|.:...|::...:..|||...|..:.|..|.:.|                  ..|. |:.
Zfish   542 GHERNEFLRKHKIDTFLIRHTPQDDKEPPKVRRTSKDETTWSAELPFDNIIGMNCILATFTNGSL 606

  Fly   678 IDLPRPTVLILTEYC--SRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGK--- 737
            :.||..    :|.:|  ||...|.:  .:|||:..:.||...|.....:.:   .|....||
Zfish   607 VHLPNQ----ITPHCAGSREINKRI--KQAIEVRSSERMRKEHITPFTLVF---KDTHIEGKFSQ 662

  Fly   738 -------------------LRSCNCLIDG--------RFVLKISDFGLRTLTTPSDFVRDQNYYL 775
                               :.:...||..        :|::.:..:.|..|.|.::..:....||
Zfish   663 MRDEMFKSNLACSFLLLLFIMAAQALIPSPQFFPMIIQFLVFLFVYMLVLLVTLAEEFKRSPPYL 727

  Fly   776 KLL--WI-----APELLPLTTIPGCCPATQRGDVYSFGIILEEIVNRGGPYQEAR---------Q 824
            :.|  ||     ...||.||.|           ..:||:....|....|.::|..         :
Zfish   728 QHLCCWIHETKSIRNLLTLTAI-----------AINFGVASCNIFWCNGTFEETEKSNKNSEHGK 781

  Fly   825 QMDVHTILH----------KVRQCNGFRPLIRERECPPDLLE-------------LMEKCW---- 862
            |..|:...|          .:..|..|..|    .|   ||:             |:|..:
Zfish   782 QWPVNICTHPEFFVLSGVVAMVTCAVFLRL----SC---LLKLAVLTLVIAVYTYLIEVAFHVLF 839

  Fly   863 ----ADNQEERPTFSTIRSNIRTIMKGFCENLMDDLLNRMEQYANNLESLVEEKTRQ----LSLE 919
                .::|.:|..:...:.....:|..|...::.:  :|..:..:.|:.|...:.||    :...
Zfish   840 IRQHQNSQIQRSQYLRRKGISVLLMAMFVVVVLYN--SRQLETTSRLDFLWRLQARQEVEDMKEL 902

  Fly   920 KQRTEELLYQILPRPVAQQLMAGDLVEPEEFSS----VTIYFSDIVGFTELCARS----SPMDVV 976
            ::..|.|||.|||..||:..:..|....:.||.    |.:.|:.|.||::...:.    ..::.:
Zfish   903 REHNECLLYNILPAHVARHFLERDRNNEDLFSESYERVGVMFASIPGFSDYYEKKELIHQDVECL 967

  Fly   977 NFLNDLYSTFDRIIG---FYDVYKVETIGDAYLVVSGL-PEPNGDK----HAREIALMALDILRA 1033
            ..||::.:.||.::.   |.|:.|::|||..|:..||| ||....:    |...:.|.||.:...
Zfish   968 RLLNEIIADFDELLDEPYFQDIEKIKTIGSCYMAASGLSPEKQECEDEWAHLSTLVLFALAMQET 1032

  Fly  1034 VSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSAT 1098
            :...|.|...::  .:|:|:..|.|.|||:|...|.|.::|.|||.||||:|||..|:|.|..||
Zfish  1033 LKEINKRTSNDF--WLRVGISHGPVVAGVIGATKPQYDIWGMTVNLASRMDSTGLSGRIQVPEAT 1095

  Fly  1099 KAILDKFGTFQMEQRGDVELKG----KGTVTTYWLNS 1131
            ..:|.:.| |.::.||::.:||    :|.|.||:::|
Zfish  1096 SRVLAEHG-FMLQLRGEIYVKGVSERRGAVRTYFVSS 1131

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	73/457 (16%)
		ANF_receptor	107..479	CDD:279440	64/410 (16%)
		PKc_like	616..885	CDD:304357	66/369 (18%)
		TyrKc	627..877	CDD:197581	65/350 (19%)
		HNOBA	<882..939	CDD:285003	16/60 (27%)
		CYCc	918..1109	CDD:214485	67/206 (33%)
		Guanylate_cyc	945..1131	CDD:278633	66/205 (32%)
si:ch211-132f19.7	XP_688903.4	AC_N	<133..375	CDD:292831	55/301 (18%)
		CYCc	338..537	CDD:214485	54/330 (16%)
		Guanylate_cyc	381..559	CDD:278633	51/308 (17%)
		DUF1053	579..667	CDD:283888	19/96 (20%)
		CYCc	903..1103	CDD:214485	66/201 (33%)
		Guanylate_cyc	932..1131	CDD:278633	66/201 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900