Protein Alignment CG3216 and gucy1a1

DIOPT Version :10

• Sequence 1: NP_726013.2
• Gene: CG3216 / 37376
• FlyBaseID: FBgn0034568
• Length: 1161
• Species: Drosophila melanogaster
• Sequence 2: NP_001296458.1
• Gene: gucy1a1 / 550420
• ZFINID: ZDB-GENE-050417-230
• Length: 679
• Species: Danio rerio
• Alignment Length: 611
• Identity: 177/611 - (28%)
• Similarity: 258/611 - (42%)
• Gaps: 135/611 - (22%)

  Fly   559 LQKQMKLSKELNNMSWRVR-PDDVL-IEMG-----GMFGSKGGLQRLDVENISLQQFGIHSGRAS 616
            |....:||..:.|.|.:.. |.|.| |.:|     ..:...|.:.|  |...:|..| ::|....
Zfish   110 LDNAEQLSDVMKNYSLKTGIPMDALKISLGLEVFRDCYEEDGHILR--VVGGALHDF-LNSFNVL 171

  Fly   617 IASFTSLPPQVYTTIGQFKGERVAIKKVNVKKVDLTPQLLWEIKQARDVSHENTVRFVGACIDLP 681
            :...|...|::...|.|          .::..:|..|.||             ||.|..     |
Zfish   172 LKQSTPPTPEIQRYIHQ----------ASILCLDKDPGLL-------------TVYFFN-----P 208

  Fly   682 RPTVLILTE----------YCSRGSLK-DVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAH 735
            .|:..:...          ||:|..:: ||...::..|..:.:..|::.:|
Zfish   209 LPSTELFFSGIIQAAACLLYCTRVEVRMDVGGKDSGALQADHQPHLLYSVV-------------- 259

  Fly   736 GKLRSCNCLIDGRFVLKISDFGLRTLTT------------PSDFVRDQNYYLKLLWIAPELLPLT 788
                    :.|||   .::...:||.|:            |...:.||.  :.||.|...|....
Zfish   260 --------VRDGR---SLTPSPMRTHTSGDIPLSLLYSTFPFHILLDQE--MGLLQIGDGLRRRL 311

  Fly   789 TIPGCCPATQRGDVYS--FGIILEEIVNRGGPYQEARQQMDVHTILHKVRQ-------------- 837
               |.|...||...::  |.|:..||   ...:|:....::...:| :|:|
Zfish   312 ---GRCRDGQRRPAFNEHFAIVSPEI---RASFQDILTMLNTQFLL-RVKQHGASSADSPGKHMD 369

  Fly   838 CNGFRPLIRERECPPDLLELMEKCWADNQEER----------PTFSTIRSNIRTIMKGFCENLMD 892
            ..|....:.|...   ||.|...| .|..||.          |..:.:|.   .::.|......|
Zfish   370 LKGQMIFMSEMSA---LLFLGSPC-VDKLEELTGRGLYLSDIPIHNALRD---VVLVGEQTKAQD 427

  Fly   893 DLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYF 957
            .|..|:    ...::.:|:..:.|..||:||.|||:.|.|..|||:|..|..|:.::|..||:.|
Zfish   428 GLKKRL----GKAKAALEQAHQALEEEKRRTVELLFTIFPGNVAQRLWQGLPVQAKKFDHVTVLF 488

  Fly   958 SDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHARE 1022
            |||||||.:|:|.:||.|||.|::||:.||...|..||||||||||||.|..|| ......||.:
Zfish   489 SDIVGFTAICSRCTPMQVVNMLSELYTRFDHHCGELDVYKVETIGDAYCVAGGL-HKESPTHAVQ 552

  Fly  1023 IALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTG 1087
            ||||||.::..  |..:.......|::|||:|||||.|||||.|||.|||||:.|..|::.||..
Zfish   553 IALMALKMMEL--SDEVTTPMGEVIRMRIGIHSGSVLAGVVGVKMPRYCLFGNNVTLANKFESCS 615

  Fly  1088 QPGKIHVSSATKAILDKFGTFQMEQR 1113
            .|.||:||..|..:|.....|.:..|
Zfish   616 LPRKINVSPTTYRLLKDCPEFTLIPR 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_GC-like	90..501	CDD:380575
		Protein Kinases, catalytic domain	616..885	CDD:473864	57/317 (18%)
		HNOBA	<891..939	CDD:462234	17/47 (36%)
		CYCc	918..1109	CDD:214485	96/190 (51%)
gucy1a1	NP_001296458.1	HNOBA	279..470	CDD:462234	48/210 (23%)
		Guanylate_cyc	476..647	CDD:425528	84/169 (50%)