DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and NPR3

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_001191304.1	Gene:	NPR3 / 4883	HGNCID:	7945	Length:	541	Species:	Homo sapiens

Alignment Length:	501	Identity:	143/501 - (28%)
Similarity:	235/501 - (46%)	Gaps:	89/501 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 FDLERCGPAVDLALDEI-----NKVFLKPHNITLLKKKGSYPSCSGARA-----PGLAADMYFQD 157
            |.|.|..||::.||..:     .:..|.|.....:..:.|  .| |.||     ..:||....:.
Human    67 FSLTRVRPAIEYALRSVEGNGTGRRLLPPGTRFQVAYEDS--DC-GNRALFSLVDRVAAARGAKP 128

  Fly   158 DVIAFIGPACAFALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTSGILGRIHKWKNENTGMFK 222
            |:|  :||.|.:|..||||||::|:.|::         |.|.|..     |..||
Human   129 DLI--LGPVCEYAAAPVARLASHWDLPML---------SAGALAA-----GFQHK---------- 167

  Fly   223 DKSKYPTLTRMSYCQCRLILVFASVIRQFNWNHVALLV--DRSELFSWTVGKNLEYGLRQEGLLS 285
             .|:|..|||::....::..:..::.|..:|:..||:.  |:.|...:...:.:....::|||.:
Human   168 -DSEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVFQEEGLHT 231

  Fly   286 FVKELNGNEEEVYENYLKDASMYARVVILSVRGVLVRKFMLAAHSLGMTNGEWVFLDVEIFQSEY 350
            .:...:..::...|:.:::.....||||:......:|..||.||..|||:|::.|.::|:|.|..
Human   232 SIYSFDETKDLDLEDIVRNIQASERVVIMCASSDTIRSIMLVAHRHGMTSGDYAFFNIELFNSSS 296

  Fly   351 WGDKGWEMKDEHDAKARKAYEALLRVSLLQPTSPKFQDFADNVRENA------LYDYNYTFGEGE 409
            :||..|:..|:||.:|::||.:|..|:||:...|:|:.|:..|:.:.      :.||
Human   297 YGDGSWKRGDKHDFEAKQAYSSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGLNMEDY-------- 353

  Fly   410 EVNFFIGAFYDGVYLLGMALNETLTEGGDIRDGVNITRRMWNRTFEGITGHVRIDDNGDRDADYS 474
             ||.|:..|:|.:.|..:||:|.|..|...:||..|.::.||||||||.|.|.||.||||..|:|
Human   354 -VNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFS 417

  Fly   475 ILDLDPINGKFSVVAHYSGVHKVYSAVHGKKIHWPGGREEPPPDVP-PCGFL------------G 526
            ::.:..:.         :|..:|.....||:     ||.|..|:|. |.|.|            .
Human   418 VIAMTDVE---------AGTQEVIGDYFGKE-----GRFEMRPNVKYPWGPLKLRIDENRIVEHT 468

  Fly   527 NSTDCVGN----FSTIMYSVFGLLLFLGLVFLVICLLQKQMKLSKE 568
            ||:.|..:    .|.:...|.|.||..||: :.....:|:.:::.|
Human   469 NSSPCKSSGGLEESAVTGIVVGALLGAGLL-MAFYFFRKKYRITIE 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	120/410 (29%)
		ANF_receptor	107..479	CDD:279440	117/389 (30%)
		PKc_like	616..885	CDD:304357
		TyrKc	627..877	CDD:197581
		HNOBA	<882..939	CDD:285003
		CYCc	918..1109	CDD:214485
		Guanylate_cyc	945..1131	CDD:278633
NPR3	NP_001191304.1	PBP1_NPR_C_like	54..446	CDD:107381	126/431 (29%)
		ANF_receptor	71..422	CDD:279440	117/389 (30%)
		TM_EphA1	476..507	CDD:214014	7/31 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.876977	Normalized mean entropy	S7115
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.760