DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and Gycbeta100B

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster

Alignment Length:	947	Identity:	215/947 - (22%)
Similarity:	348/947 - (36%)	Gaps:	297/947 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 EEVYENYLKDA-----------SMYARVVILSVRGVLVRKFMLAAHSLGMTNGEWVFLDVEIFQS 348
            ||::|...|.|           .:|...:..::.|..|....:.|..:....|:..|
  Fly    19 EEIWEKIKKKAMVSMEGQFLVRQIYDDEITYNLIGAAVEILNIPADDILELFGKTFF-------- 75

  Fly   349 EYWGDKGWEMKDEHDAKARKAYEALLRVSLLQPTSPKFQDFADNVRENALYDYNYTFGEGEEVNF 413
            |:..|.|              |:.:|:|....|     :||..|:  :||:|:..|...|.....
  Fly    76 EFCQDSG--------------YDKILQVLGATP-----RDFLQNL--DALHDHLGTLYPGMRAPS 119

  Fly   414 FIGAFYDGVYLL-------------------------------------GMALNETLTEGGDIRD 441
            |.....||..||                                     |..::|...|....|:
  Fly   120 FRCTEKDGELLLHYYSERPGLEHIVIGIVKAVASKLHGVEVEIDIVKRKGEPIDEAEKERAIARE 184

  Fly   442 GVNITRRMWNRTFEGITGHVRI----DDNGDRDADYSILDLDPINGKFSVVAHYSGVHKVYSAVH 502
            ...:.......|   .||...:    ..:.:|:.:::..:....||    :|:......|.:...
  Fly   185 NQQLLEDAVATT---TTGSATVVLAPSSDAERNNNHNGSNGSNNNG----MANNGNTVNVNNNND 242

  Fly   503 GKKIHWPGGREEPPPDVPPCGFLGNSTDCVGNFSTIMYSVFGLLLFLGLVFLVICLLQKQMKLSK 567
            |::|   ....:|...:..|....:|.||.|:                          |:.|..:
  Fly   243 GQQI---ASETDPSIALSTCPIAQDSFDCDGD--------------------------KEQKCLR 278

  Fly   568 ELNNMSWRVRPDDVLIEMGGMFGSKGGLQRLDVENISLQQFGIHSGRASIASFTSLPPQVYTTIG 632
            .|.|.|     ||:              :|.|.....:::..:.:.....|....:|..:
  Fly   279 LLKNKS-----DDI--------------ERYDHVQFLIREINVAAKSQVDAKKDEVPDDM----- 319

  Fly   633 QFKGERVAIKKVNVKKVDLTPQLLWEIKQARDVSHENTVRFVGACIDLPRPTVLILTEYCSRGSL 697
            :|..|...|......||  .|..|...:|.:.|.....|..|     :||    :..|.|   ||
  Fly   320 EFLCEAPLISPATFCKV--FPFHLMFDRQMKIVQAGKAVSRV-----IPR----VAEENC---SL 370

  Fly   698 KDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGLRTLT 762
            .:|:|.....|..||...|.|                          |:..:||:.....:.:
  Fly   371 IEVVEAIRPHLQLNFENILSH--------------------------INTIYVLQTRQGAMSS-- 407

  Fly   763 TPSDFVRDQNYYLKL---LWIAPELLPLTTIPGCCPATQR-GDVYSFGIILEEIVNRGGPYQEAR 823
                  |.:..:|:|   :...||...:  :..|.|:... .|:...|:.:.::     |..:|.
  Fly   408 ------RHEQRFLRLKGQMMYIPETDRI--LFQCYPSVMNLDDLTKKGLYISDV-----PLHDAA 459

  Fly   824 QQMDVHTILHKVRQCNGFRPLIRERECPPDLLELMEKCWADNQEERPTFSTIRSNIRTIMKGFCE 888
            :                            ||:.|.||..|:.:                   ..:
  Fly   460 R----------------------------DLVLLSEKFEAEYK-------------------LTK 477

  Fly   889 NLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSV 953
            || :.|.::::|...:|||           |||:|:.|||.:||:.||.:|.....|.|:.:.||
  Fly   478 NL-EMLTDKLQQTFRDLES-----------EKQKTDRLLYSVLPKSVANELRHQRPVPPKRYDSV 530

  Fly   954 TIYFSDIVGFTELCARSS----PMDVVNFLNDLYSTFDRIIGF---YDVYKVETIGDAYLVVSGL 1011
            |:.||.||||.:.||.::    .|.:|..||:||:.||.:...   .:||||||:||.|:.||||
  Fly   531 TLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGL 595

  Fly  1012 PEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDT 1076
            |: :.:.||:.:|.:|||::....:..:...|   :||.||:|||.|..||:|.::|.|||||:|
  Fly   596 PD-HCEDHAKCMARVALDMMDMAKNVKMGSNP---VQITIGIHSGEVVTGVIGNRVPRYCLFGNT 656

  Fly  1077 VNTASRMESTGQPGKIHVSSATKAIL----DKFGTFQMEQRGDVELKGKGTVTTYWL-------- 1129
            ||..||.|:||.||:|:||..|..:|    ::..:|.:|.||.|.:|||.|....|.
  Fly   657 VNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGKPTPMDCWFLTRATSSI 721

  Fly  1130 ---NSTSEGEA------------RPPTPQILTTDEVP 1151
               .|::.|..            :|.||.......:|
  Fly   722 LGGTSSTGGSGGGGNGSLDSPLLQPATPTAGAATPIP 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	42/252 (17%)
		ANF_receptor	107..479	CDD:279440	39/235 (17%)
		PKc_like	616..885	CDD:304357	46/272 (17%)
		TyrKc	627..877	CDD:197581	44/253 (17%)
		HNOBA	<882..939	CDD:285003	18/56 (32%)
		CYCc	918..1109	CDD:214485	86/201 (43%)
		Guanylate_cyc	945..1131	CDD:278633	84/207 (41%)
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	31/173 (18%)
		HNOBA	326..516	CDD:285003	60/303 (20%)
		CYCc	496..688	CDD:214485	86/195 (44%)
		Guanylate_cyc	522..714	CDD:278633	84/195 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810