DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and Gyc88E

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster

Alignment Length:	683	Identity:	197/683 - (28%)
Similarity:	294/683 - (43%)	Gaps:	189/683 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   558 LLQKQMKLSKELNNMSWRVRPDDVLIEMG----GMFGSKG-----------------GLQRLD-- 599
            ||||..|.::::..:|.|    |.:.:||    |..|..|                 ||..|.
  Fly    46 LLQKLAKKAQQVLGVSER----DFMDQMGVYFVGFVGQYGYDRVLSVLGRHMRDFLNGLDNLHEY 106

  Fly   600 --------------VENISLQQFGIHSGRASIASFTSLPPQVYTTIGQFKGERVAIKKVNVKKVD 650
                          .||.:.|...:|. |:....|      ||.|:||       |::|
  Fly   107 LKFSYPRMRAPSFICENETKQGLTLHY-RSKRRGF------VYYTMGQ-------IREV------ 151

  Fly   651 LTPQLLWEIKQARDVSHENTVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMS 715
                       ||...|:.      ..|:|.|..:|..|.:.:            .:|.::.|..
  Fly   152 -----------ARYFYHKE------MHIELVREEILFDTVHVT------------FQLTFDNRAF 187

  Fly   716 LIHDIVKGMNYLHNSDVAAHGKLRSCN-CLIDGRFVLKISDFGLRTLTTPSDFVRDQNYYLKLLW 779
            .:..:.......| ..::||....... |::.|      :|..:|::..            .|:.
  Fly   188 TLASLAMTREEKH-LPISAHVLFEIFPFCMVFG------ADMVVRSIGN------------SLMV 233

  Fly   780 IAPELL------------------------------PLTTIPGCCPATQRGDVYSFGIILEEIVN 814
            |.||||                              .|.|:.   |.|:|.||.:..::..|..:
  Fly   234 ILPELLGKKITAWFDLVRPLIAFKFQTILNRTNNIFELVTVD---PVTERFDVQNEDLLQHEDGS 295

  Fly   815 RGGPYQEARQQMDVHTILHKVRQCNGFRPLIRERECPPDLLELMEKCWADNQEERPTFSTIRSNI 879
            ........:.||        |...|....:.......|||..|:......|......||
  Fly   296 EPEKSLRLKGQM--------VYMENWRMIMFLGTPVMPDLTSLITTGLYINDLSMHDFS------ 346

  Fly   880 RTIMKGFCENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDL 944
            |.:|....:..: :|...::|.....:.| ||..|.|..|.:||:|||||::|:.||.:|..|:
  Fly   347 RDLMLAGTQQSV-ELKLALDQEQQKSKKL-EESMRLLDEEMRRTDELLYQMIPKQVADRLRRGE- 408

  Fly   945 VEP----EEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAY 1005
             .|    |.|.||:|.|||||.|||:|:|.:||:||:.||.:||.||::.....|||||||||||
  Fly   409 -NPIDTCEMFDSVSILFSDIVTFTEICSRITPMEVVSMLNAMYSIFDKLTERNSVYKVETIGDAY 472

  Fly  1006 LVVSGLPEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHY 1070
            :||:|.|:.:.: ||..:..||||::.|::........:: ::||:|:|||:|.||:||.|||.|
  Fly   473 MVVAGAPDKDAN-HAERVCDMALDMVDAITDLKDPSTGQH-LRIRVGVHSGAVVAGIVGLKMPRY 535

  Fly  1071 CLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVELKGKGTVTTYWLNSTSEG 1135
            ||||||||||||||||....|:|:|.:||.::..  .:::.:||::::|||||:.||||   .|.
  Fly   536 CLFGDTVNTASRMESTSIAMKVHISESTKVLIGP--NYKIIERGEIDVKGKGTMGTYWL---EER 595

  Fly  1136 EAR-----------------PPTPQILTTDEVP 1151
            |.|                 ||||...|...:|
  Fly   596 ENRLPLQLTAALQVHPLSPVPPTPTPKTKAIMP 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368
		ANF_receptor	107..479	CDD:279440
		PKc_like	616..885	CDD:304357	52/299 (17%)
		TyrKc	627..877	CDD:197581	49/280 (18%)
		HNOBA	<882..939	CDD:285003	19/56 (34%)
		CYCc	918..1109	CDD:214485	97/194 (50%)
		Guanylate_cyc	945..1131	CDD:278633	95/189 (50%)
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	33/158 (21%)
		HNOBA	201..404	CDD:311573	51/239 (21%)
		CYCc	383..571	CDD:214485	97/193 (50%)
		Herpes_ICP4_C	794..>955	CDD:332854
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810