DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and Ac76E

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster

Alignment Length:	623	Identity:	144/623 - (23%)
Similarity:	240/623 - (38%)	Gaps:	159/623 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   602 NISLQQFGIHSGRASIASFTS--LPPQVYTTIGQFKGERVAIKKVNVKKVDLTPQLLWEIKQARD 664
            ||:..:...:.|.||||...|  |||:.......|.|          ...:|.|..:|.....|:
  Fly   760 NIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFG----------PPTELKPFTMWYRNTPRE 814

  Fly   665 VSH----ENTVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMN 725
            ..:    :...||     ||....||.|       ||. |::...|||:.....||:...|....
  Fly   815 AMYRAQPDTHFRF-----DLICAFVLFL-------SLA-VVQLIVIELNLALLGSLLASFVSLAL 866

  Fly   726 YLHNSD-------------------VAAHGKLRSC-----NCLIDGRFVLKISDF----GLRTLT 762
            :|:.|:                   ||:...||..     |.||....|..:.::    |:....
  Fly   867 FLYLSNMSVPDVHASTTERNGPGQVVASSRYLRLAMFVVVNILISSCAVFSVINYTVPDGVSKEP 931

  Fly   763 TPSDFVRDQNYYLKL---------LWIAPELLPLTTIPGCCPATQRGDVYSF---GIILEEIVNR 815
            :.:..:.:.|:....         ||.....:|:..:...|.|.....:.:|   |.||:.|...
  Fly   932 SSNQTILESNFSSVFVNSTLEDVQLWEIDYAIPIAPVFLYCCAISLAAISAFLRSGFILKLIAML 996

  Fly   816 GGPYQEARQQMDVHTILHKVRQCNGFRPLIRERECPPDLLELMEKCWADNQEERPTFSTIRSNIR 880
            .....:.       |:|       |:          .||.|:...            :.|...:.
  Fly   997 VAVIAQV-------TVL-------GY----------SDLFEMYND------------ANITHGLP 1025

  Fly   881 TIMKGFCENLMDDL----LNRMEQYANNLESLVEEKTRQLSLEKQRTEE-------LLYQILPRP 934
            ..:|||...|:..|    |:|..:|....:.|.:.|   |.:|::..|.       ||..|||..
  Fly  1026 LEIKGFLLLLVIILVLHTLDRQGEYVARTDFLWKAK---LKVEQEEVETMRGINKILLENILPAH 1087

  Fly   935 VAQQLM----AGDLVEPEEFSSVTIYFSDIVGFTELC----ARSSPMDVVNFLNDLYSTFDRII- 990
            ||...:    :.:|.. |.:|.|.:.|:.|..:.|..    .....::.:..||::...||:::
  Fly  1088 VATHFLHLERSTELYH-ESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLL 1151

  Fly   991 --GFYDVYKVETIGDAYLVVSGL--------------PEPNGDKH----AREIALMALDILRAVS 1035
              .|..:.|::||...|:..|||              .|...::|    ..|.|:..:.||.:::
  Fly  1152 KPKFSGIEKIKTIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSIN 1216

  Fly  1036 --SFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSAT 1098
              ||.       :.::|||::.|.|.|||:|.:.|.|.::.:|||.||||:|.|..|::..:..|
  Fly  1217 RESFQ-------RFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENT 1274

  Fly  1099 KAILDKFGTFQMEQRGDVELKGKGTVTTYWLNSTSEGE 1136
            ..||...| ::.|.||...:||||.:.||::.:..:|:
  Fly  1275 AKILMTAG-YECECRGLTYVKGKGNLVTYFVKTPFDGK 1311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368
		ANF_receptor	107..479	CDD:279440
		PKc_like	616..885	CDD:304357	58/314 (18%)
		TyrKc	627..877	CDD:197581	51/293 (17%)
		HNOBA	<882..939	CDD:285003	20/67 (30%)
		CYCc	918..1109	CDD:214485	61/228 (27%)
		Guanylate_cyc	945..1131	CDD:278633	60/212 (28%)
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831
		CYCc	259..467	CDD:214485
		Guanylate_cyc	311..469	CDD:278633
		BASP1	510..667	CDD:283191
		CYCc	1079..1283	CDD:214485	59/212 (28%)
		Guanylate_cyc	1101..1305	CDD:278633	61/212 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810