DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and GUCY2D

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_000171.1	Gene:	GUCY2D / 3000	HGNCID:	4689	Length:	1103	Species:	Homo sapiens

Alignment Length:	1161	Identity:	391/1161 - (33%)
Similarity:	560/1161 - (48%)	Gaps:	223/1161 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 VYNVGVLMASHLDSPFDLERCGPAVDLALDEINKVFLKP-------HNITLLKKKGSYPSCSGAR 145
            |:.||||.....|..|...|...|..||...:|:   .|       ..:.||.:....|...||.
Human    53 VFTVGVLGPWACDPIFSRARPDLAARLAAARLNR---DPGLAGGPRFEVALLPEPCRTPGSLGAV 114

  Fly   146 APGLAADMYFQDDVIAFIGPACAFALEPVARLA-------AYWNKPIITGMGDQPPSSEGELTVT 203
            :..||.       |...:||....|..|...||       ..|..|.....|...|:    :|..
Human   115 SSALAR-------VSGLVGPVNPAACRPAELLAEEAGIALVPWGCPWTQAEGTTAPA----VTPA 168

  Fly   204 SGILGRIHKWKNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNWNHVALLVDRSELFSW 268
            :..|                                     .:::|.|.|..|||:....:|  |
Human   169 ADAL-------------------------------------YALLRAFGWARVALVTAPQDL--W 194

  Fly   269 T-VGKNLEYGLRQEGL-LSFVK-----ELNGNEEEVYENYLKDASMYARVVILSVRGVLV----R 322
            . .|::|...||..|| ::.|.     :|:|..|.:.:  ::|... ...||:.:..||:    :
Human   195 VEAGRSLSTALRARGLPVASVTSMEPLDLSGAREALRK--VRDGPR-VTAVIMVMHSVLLGGEEQ 256

  Fly   323 KFML-AAHSLGMTNGEWVFLDVEIFQSEYWGDKGWEMKD--EHDAKARKAYEALLRVSLLQPTSP 384
            :::| ||..||:|:|..|||..:..  .|....|.|...  .:.::.|:|::|:|.::...|:..
Human   257 RYLLEAAEELGLTDGSLVFLPFDTI--HYALSPGPEALAALANSSQLRRAHDAVLTLTRHCPSEG 319

  Fly   385 KFQDFADNVRENALY--DYNYTFGEGEEVNFFIGAFYDGVYLLGMALNET-LTEGGDIRDGVNIT 446
            ...|.....:|....  |.|.     ::|:...|..||.|:||...:.|. ...||....|..:.
Human   320 SVLDSLRRAQERRELPSDLNL-----QQVSPLFGTIYDAVFLLARGVAEARAAAGGRWVSGAAVA 379

  Fly   447 RRMWNRTFEGITGHVRIDDNGDRDADYSILD-------------LDPINGKFSVVAHYSGVHKVY 498
            |.:.:....|..|    |..||.:..:.:||             |||..|.|            .
Human   380 RHIRDAQVPGFCG----DLGGDEEPPFVLLDTDAAGDRLFATYMLDPARGSF------------L 428

  Fly   499 SAVHGKKIHWPGGREEPPPDVPPCGFLGNSTDCVGNFSTIMYSVF-GLLLFLGL----VFLVICL 558
            ||  |.::|:|.|...|.|| |.|.|..|:. |.|.....:  || |.||.:|:    .||...:
Human   429 SA--GTRMHFPRGGSAPGPD-PSCWFDPNNI-CGGGLEPGL--VFLGFLLVVGMGLAGAFLAHYV 487

  Fly   559 LQK--QMKLSKELNNMSWRVRPDDV--LIEMGGMF-----GSKGGLQRLDVENISLQQFGIHSGR 614
            ..:  .|::....|.:...|  ||:  |...||..     ||:..|                 |.
Human   488 RHRLLHMQMVSGPNKIILTV--DDITFLHPHGGTSRKVAQGSRSSL-----------------GA 533

  Fly   615 ASIASFTSLPPQVYTT--IGQFKGERVAIKKV-NVKKVDLTPQLLWEIKQARDVSHENTVRFVGA 676
            .|::...|.|.|...:  ||.::|:||.:||. ..:.:.:.|.......:.:::.|||...::|
Human   534 RSMSDIRSGPSQHLDSPNIGVYEGDRVWLKKFPGDQHIAIRPATKTAFSKLQELRHENVALYLG- 597

  Fly   677 CIDLPR----PTVL------ILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSD 731
             :.|.|    |..|      :::|:|:||||:|:|....|:|||.|:.||:.|::||:.|||:..
Human   598 -LFLARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLHHRG 661

  Fly   732 VAAHGKLRSCNCLIDGRFVLKISDFG-------LRTLTTPSDFVRDQNYYLKLLWIAPELLPLTT 789
            | |||:|:|.||::||||||||:|.|       .:.|..|.. ..||      ||.|||||.
Human   662 V-AHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVLPEPPR-AEDQ------LWTAPELLR--- 715

  Fly   790 IPGCCPATQR-----GDVYSFGIILEEIVNRGGPYQEARQQMDVHTILHKVRQ----CNGFRPLI 845
                .||.:|     |||:|..||::|:|.|..||  |..::....::.:||.    |   |||:
Human   716 ----DPALERRGTLAGDVFSLAIIMQEVVCRSAPY--AMLELTPEEVVQRVRSPPPLC---RPLV 771

  Fly   846 RERECPPDLLELMEKCWADNQEERPTFSTIRSNIRTIMKGFCENLMDDLLNRMEQYANNLESLVE 910
            ...:.|.:.:.||::|||:..|.||:........:.|.||...|::|.:|..:|||::|||.|:.
Human   772 SMDQAPVECILLMKQCWAEQPELRPSMDHTFDLFKNINKGRKTNIIDSMLRMLEQYSSNLEDLIR 836

  Fly   911 EKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDV 975
            |:|.:|.||||:|:.||.|:||..||:.|..|..||||.|..||:|||||||||.:.|.|.|::|
Human   837 ERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEV 901

  Fly   976 VNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLR 1040
            |:.|||||:.||.|||.:||||||||||||:|.||||:.||.:||.|||.|:||||.||.:|.:|
Human   902 VDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMR 966

  Fly  1041 HKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKF 1105
            |.||..::||||:|||...|||||..||.||||||||||||||||||.|.:|||:.:|..||...
Human   967 HMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRAL 1031

  Fly  1106 GT-FQMEQRGDVELKGKGTVTTYWL---NSTSEGEARPPTPQI------LTTDEVP 1151
            .: :|:|.||..||||||...|:||   ...::...:||..|.      ::..|:|
Human  1032 DSGYQVELRGRTELKGKGAEDTFWLVGRRGFNKPIPKPPDLQPGSSNHGISLQEIP 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	101/449 (22%)
		ANF_receptor	107..479	CDD:279440	90/415 (22%)
		PKc_like	616..885	CDD:304357	101/297 (34%)
		TyrKc	627..877	CDD:197581	96/278 (35%)
		HNOBA	<882..939	CDD:285003	28/56 (50%)
		CYCc	918..1109	CDD:214485	120/191 (63%)
		Guanylate_cyc	945..1131	CDD:278633	119/189 (63%)
GUCY2D	NP_000171.1	PBP1_sensory_GC_DEF-like	55..431	CDD:380594	103/456 (23%)
		PK_GC-2D	536..811	CDD:270945	100/296 (34%)
		HNOBA	<820..865	CDD:369471	23/44 (52%)
		CYCc	846..1036	CDD:214485	118/189 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1065..1103		5/23 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820