DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and GUCY2C

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_004954.2	Gene:	GUCY2C / 2984	HGNCID:	4688	Length:	1073	Species:	Homo sapiens

Alignment Length:	1172	Identity:	347/1172 - (29%)
Similarity:	533/1172 - (45%)	Gaps:	248/1172 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 DAGLEQRMYERSRESKSTQLSRYTEVGEMGSTMRVYNVGVLMASHLDSPFDLERCGPAVDLALD- 117
            |..|...:::....|.|:|:|:....|.       |.:.|||..:......|:....||:..|:
Human     7 DLALWSLLFQPGWLSFSSQVSQNCHNGS-------YEISVLMMGNSAFAEPLKNLEDAVNEGLEI 64

  Fly   118 ------------EINKVFLKPHNITLLKKKGSYPSCSGARAPGLAADMYFQDDVI---------- 160
                        .:|..|:  ::..|:...|   .|..:...||        |::
Human    65 VRGRLQNAGLNVTVNATFM--YSDGLIHNSG---DCRSSTCEGL--------DLLRKISNAQRMG 116

  Fly   161 -AFIGPACAFALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTSGILGRIHKWKNENTGMFKDK 224
             ..|||:|.:     :....|.:..:...|            :::|..|....:|.
Human   117 CVLIGPSCTY-----STFQMYLDTELSYPM------------ISAGSFGLSCDYKE--------- 155

  Fly   225 SKYPTLTRMSYCQCRLILVFASVIRQFNWNHVALLVDRSELFSWTVGKNLEYGLRQEGLLSFVKE 289
                ||||: ....|.::.|  ::..:..|.:..     :.:||:.....:.|...|....::..
Human   156 ----TLTRL-MSPARKLMYF--LVNFWKTNDLPF-----KTYSWSTSYVYKNGTETEDCFWYLNA 208

  Fly   290 LNGN---------------EEEVYENYLKDASMYARVVILSVRGVLVRKF---MLAAHSLGMTNG 336
            |..:               :::.:::.|.|.:..:.|:|:......:.|.   ...|..:
Human   209 LEASVSYFSHELGFKVVLRQDKEFQDILMDHNRKSNVIIMCGGPEFLYKLKGDRAVAEDI----- 268

  Fly   337 EWVFLDVEIFQSEYWGDKGWEMKDEHDAKARKAYEALLRVSLLQPTSPKFQDFADNV------RE 395
              |.:.|::|..:|:.|                          ..|:|   |:..||      ..
Human   269 --VIILVDLFNDQYFED--------------------------NVTAP---DYMKNVLVLTLSPG 302

  Fly   396 NALYDYNYTFGEGEEVNFFIGAFYDGVYLLGMALNETLTEGGDIRDGVNITRRMW-----NRTFE 455
            |:|.:.:::.........|..|:.:|:.|.|..|...|      .:|.|||...:     |.|||
Human   303 NSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKIFL------ENGENITTPKFAHAFRNLTFE 361

  Fly   456 GITGHVRIDDNGDRDADYSILDLDPINGKFSVVAHY-SGVHKVYSAVHGKKIHWPGGREEPPPDV 519
            |..|.|.:||.||.|:...:|.......|:.|:..| :.|:|.|                 |.|:
Human   362 GYDGPVTLDDWGDVDSTMVLLYTSVDTKKYKVLLTYDTHVNKTY-----------------PVDM 409

  Fly   520 PPCGFLGNS---TDCVGNFSTI-MYSVFGLLLFLGLVFLVICLLQKQMKLSKELNNMSW-RVRPD 579
            .|.....||   .|..|....| |.:||.|...:.|:.||..|:.::.:...||....| .:.|:
Human   410 SPTFTWKNSKLPNDITGRGPQILMIAVFTLTGAVVLLLLVALLMLRKYRKDYELRQKKWSHIPPE 474

  Fly   580 DVLIEMGGMFGSKGGLQRLDVENISLQQFGIHSGRASIASFTSLPPQVYTTIGQFKGERVAIKKV 644
            ::.           .|:..:..::|| :......|.:|......         ::..:||.:|.:
Human   475 NIF-----------PLETNETNHVSL-KIDDDKRRDTIQRLRQC---------KYDKKRVILKDL 518

  Fly   645 NVKKVDLTPQLLWEIKQARDVSHENTVRFVGACIDLPRPTVLI-LTEYCSRGSLKDVLENEAIE- 707
            .....:.|.:...|:.:...:.:.|..:|.|.   :...|::. :.|||.||||::|| |:.|.
Human   519 KHNDGNFTEKQKIELNKLLQIDYYNLTKFYGT---VKLDTMIFGVIEYCERGSLREVL-NDTISY 579

  Fly   708 -----LDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGLRTLTTPSDF 767
                 :||.|::|:::||.|||:|||:|....||:|:|.||::|.|.|:||:|||..::..|.
Human   580 PDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPK-- 642

  Fly   768 VRDQNYYLKLLWIAPELLPLTTIPGCCPATQRGDVYSFGIILEEIVNRGGPYQEARQQMDVHTIL 832
                    |.||.|||.|....|      :|:|||||:|||.:||:.|...:.....: |.:..:
Human   643 --------KDLWTAPEHLRQANI------SQKGDVYSYGIIAQEIILRKETFYTLSCR-DRNEKI 692

  Fly   833 HKVRQCNGFRPLIRERECPPDL---------LE---LMEKCWADNQEERPTFSTIRSNIRTIMKG 885
            .:|...||.:|.      .|||         ||   |::.||.::.|:||.|..|.:.:..|...
Human   693 FRVENSNGMKPF------RPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAKIFGL 751

  Fly   886 F----CENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVE 946
            |    .|:.||.|:.|::.|:.|||.||||:|:....|:.|.:.|.:.:|||.|.:.|.....||
Human   752 FHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVE 816

  Fly   947 PEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGL 1011
            ||.:..||||||||||||.:|..|:||:||:.|||:|.:||.|:..:||||||||||||:|.|||
Human   817 PELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGL 881

  Fly  1012 PEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDT 1076
            |:.||::||.:||.|||:||..:.:|.|.|.|...|.||||:|||...|||||.|||.|||||||
Human   882 PKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDT 946

  Fly  1077 VNTASRMESTGQPGKIHVSSATKAILDKFG-TFQMEQRGDVELKGKGTVTTYWLNSTSEGEARPP 1140
            |||||||||||.|.:||||.:|.|||.:.. .|..|.||:..|||:|..|||||....:.:...|
Human   947 VNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLP 1011

  Fly  1141 TP 1142
            ||
Human  1012 TP 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	82/459 (18%)
		ANF_receptor	107..479	CDD:279440	74/424 (17%)
		PKc_like	616..885	CDD:304357	88/287 (31%)
		TyrKc	627..877	CDD:197581	86/268 (32%)
		HNOBA	<882..939	CDD:285003	23/60 (38%)
		CYCc	918..1109	CDD:214485	112/191 (59%)
		Guanylate_cyc	945..1131	CDD:278633	117/186 (63%)
GUCY2C	NP_004954.2	PBP1_GC_C_enterotoxin_receptor	35..415	CDD:107364	88/489 (18%)
		PK_GC-C	480..750	CDD:270946	91/306 (30%)
		Pkinase_Tyr	502..745	CDD:285015	86/278 (31%)
		CYCc	788..979	CDD:214485	112/190 (59%)
		Guanylate_cyc	815..1002	CDD:278633	117/186 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820