DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and GUCY1A2

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_001243353.1	Gene:	GUCY1A2 / 2977	HGNCID:	4684	Length:	763	Species:	Homo sapiens

Alignment Length:	651	Identity:	186/651 - (28%)
Similarity:	269/651 - (41%)	Gaps:	162/651 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   542 VFGLLL----FLGLVFLVICLLQKQMKLSKELNNMSWRVRPDDVLIEMGG--------------- 587
            |.|:|.    .|||.|..|     |.:..:|..|:.:. ..:.||..:||
Human   151 VSGILQCTANILGLKFEEI-----QKRFGEEFFNICFH-ENERVLRAVGGTLQDFFNGFDALLEH 209

  Fly   588 ---MFGSKGGLQ-------RLDVENISLQQFGIHSGRASIASFTSLPPQVYTTIGQFKGERVAIK 642
               .||.:..|:       .|....:.|..|..|    .|..|..|        |..|.....|.
Human   210 IRTSFGKQATLESPSFLCKELPEGTLMLHYFHPH----HIVGFAML--------GMIKAAGKKIY 262

  Fly   643 KVNVKKVDLTPQLLWEIKQARDVSHENTVRFVGACIDLPRP----TVLILTEYCSRGSLKDVLEN 703
            :::|           |::|   |::|.      .|.|:..|    .:..|.:.|...::...|..
Human   263 RLDV-----------EVEQ---VANEK------LCSDVSNPGNCSCLTFLIKECENTNIMKNLPQ 307

  Fly   704 EAIELDWNFRMS-----------LIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISD-F 756
            ...::..:.|:|           |:.|  ..|:.|.    ...|..:...|  |...|||..| |
Human   308 GTSQVPADLRISINTFCRAFPFHLMFD--PSMSVLQ----LGEGLRKQLRC--DTHKVLKFEDCF 364

  Fly   757 GLRTLTTPSDFVRDQNYYLKLLWIAPELLPLTTIPGCCPATQRGDVYSFGIILEEIVNRGGPYQE 821
            .:.:....:.|.|             .||.|:|     |...|....:.|...::.|      .|
Human   365 EIVSPKVNATFER-------------VLLRLST-----PFVIRTKPEASGSENKDKV------ME 405

  Fly   822 ARQQMDVHTILHKVRQCNGFRPLIRERECPPDLLELMEKCWADNQEERPTFSTIRSNIRTIMKGF 886
            .:.|| :|     |.:.|..  |.....|...|.|||.:  ..:..:.|.....|.   .|:.|.
Human   406 VKGQM-IH-----VPESNSI--LFLGSPCVDKLDELMGR--GLHLSDIPIHDATRD---VILVGE 457

  Fly   887 CENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFS 951
            .....|.|..||::    |::.:|...:.|..||::|.:|||.|.|..|||||..|..|:..:|.
Human   458 QAKAQDGLKKRMDK----LKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFD 518

  Fly   952 SVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNG 1016
            .||:.||||||||.:||:.:||.|::.||:||:.||...||.|:||||||||||.|.:|| ....
Human   519 DVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGL-HRKS 582

  Fly  1017 DKHAREIALMALDIL-------------------RAVSSFNL-------RHKPEYKI---QIRIG 1052
            ..||:.||||||.::                   ..:.||.:       :|:.|..:   ::|||
Human   583 LCHAKPIALMALKMMELSEEVLTPDGRPIQPQRSELLFSFPVSIQLVPDQHQSETDLGTEKMRIG 647

  Fly  1053 MHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVE 1117
            :|||||.|||||.:||.|||||:.|..||:.||...|.:|:||..|..:|.:..:|....|...|
Human   648 IHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREESFTFIPRSREE 712

  Fly  1118 L 1118
            |
Human   713 L 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368
		ANF_receptor	107..479	CDD:279440
		PKc_like	616..885	CDD:304357	56/284 (20%)
		TyrKc	627..877	CDD:197581	51/265 (19%)
		HNOBA	<882..939	CDD:285003	20/56 (36%)
		CYCc	918..1109	CDD:214485	96/219 (44%)
		Guanylate_cyc	945..1131	CDD:278633	86/203 (42%)
GUCY1A2	NP_001243353.1	HNOB	<159..270	CDD:285002	27/139 (19%)
		HNOBA	316..503	CDD:285003	55/235 (23%)
		CYCc	485..705	CDD:214485	97/220 (44%)
		Guanylate_cyc	514..729	CDD:278633	85/201 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810