DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and Gucy2c

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_037302.1	Gene:	Gucy2c / 25711	RGDID:	2771	Length:	1072	Species:	Rattus norvegicus

Alignment Length:	1121	Identity:	351/1121 - (31%)
Similarity:	526/1121 - (46%)	Gaps:	209/1121 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 YNVGVLMASHLDSPFDLERCGPAVDLALDEINKVFLKPH-NIT----------LLKKKGSYPSCS 142
            |.:.|||..:......|:....||:..||.:.|...:.. |:|          |:.|.|   .|.
  Rat    34 YEISVLMMDNSAYKEPLQNLRDAVEEGLDIVRKRLREAELNVTVNATFIYSDGLIHKSG---DCR 95

  Fly   143 GARAPGLAADMYFQDDVI-----------AFIGPACAFALEPVARLAAYWNKPIITGMGDQPPSS 196
            .:...||        |::           ..:||:|.::...: .|....|.|:|
  Rat    96 SSTCEGL--------DLLREITRDRKMGCVLMGPSCTYSTFQM-YLDTELNYPMI---------- 141

  Fly   197 EGELTVTSGILGRIHKWKNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNWNHVALLVD 261
                  ::|..|....:|...|.:.      |...::.|.......|..:..:.|:||...:..:
  Rat   142 ------SAGSFGLSCDYKETLTRIL------PPARKLMYFLVDFWKVNNAPFKTFSWNSSYVYKN 194

  Fly   262 RSE---LFSWTVGKNLEYGLRQ-EGLLSFVKELNGNEEEVYENYLKDASMYARVVIL-------- 314
            .||   .| |.:.. ||.|:.. ..:|||...|..:|:  ::..|...:..:.|:::
  Rat   195 GSEPEDCF-WYLNA-LEAGVSYFSEVLSFKDVLRRSEQ--FQEILMGRNRKSNVIVMCGTPETFY 255

  Fly   315 SVRGVLVRKFMLAAHSLGMTNGEWVFLDVEIFQSEYWGDKGWEMKDEHDAKARKAYEALLRVSLL 379
            :|:|.|            ....:.|.:.|::|.:.|:         |.|.:|.:..:.:| |..|
  Rat   256 NVKGDL------------KVADDTVVILVDLFSNHYF---------EDDTRAPEYMDNVL-VLTL 298

  Fly   380 QPTSPKFQDFADNVRENALYDYNYTFGEGEEVNFFIGAFYDGVYLLGMALNETLTEGGDIRDGVN 444
            .|     :.|..|...:..:       ..|..:|.: |:.:|..|.|..| :|..|.|:......
  Rat   299 PP-----EKFIANASVSGRF-------PSERSDFSL-AYLEGTLLFGHML-QTFLENGESVTTPK 349

  Fly   445 ITRRMWNRTFEGITGHVRIDDNGDRDADYSILDLDPINGKFSVVAHYSGVHK--VYSAVHGKKIH 507
            ..|...|.||:|:.|.|.:||:||.|....:|.:.....|:.|:..|. .||  ...........
  Rat   350 FARAFRNLTFQGLEGPVTLDDSGDIDNIMCLLYVSLDTRKYKVLMAYD-THKNQTIPVATSPNFI 413

  Fly   508 WPGGREEPPPDVPPCGFLGNSTDCVGNFSTIMYSVFGLLLFLGLVFLVICLLQKQMKLSKELNNM 572
            |...|  .|.|||..|           ...:|.:||.|...:.::.|:..|:.::.:...||...
  Rat   414 WKNHR--LPNDVPGLG-----------PQILMIAVFTLTGIVVVLLLIALLVLRKYRRDHELRQK 465

  Fly   573 SWRVRPDDVLIEMGGMFGSKGGLQRLDVENISLQQFGIHSGRASIASFTSLPPQVYTTIGQFKGE 637
            .|...|.:.:..          |:..:..::||:   |...|..            .||.:.:..
  Rat   466 KWSHIPSENIFP----------LETNETNHVSLK---IDDDRRR------------DTIQRVRQC 505

  Fly   638 RVAIKKVNVKKV-----DLTPQLLWEIKQARDVSHENTVRFVGAC-IDLPRPTVLILTEYCSRGS 696
            :...|||.:|.:     :.:.:...|:.:.....:.|..:|.|.. :|   ..:..:.|||.|||
  Rat   506 KYDKKKVILKDLKHCDGNFSEKQKIELNKLLQSDYYNLTKFYGTVKLD---TRIFGVVEYCERGS 567

  Fly   697 LKDVLENEAIE------LDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISD 755
            |::|| |:.|.      :||.|::|:::||.|||:|||:|.:..||:|:|.||::|.|.|:||:|
  Rat   568 LREVL-NDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITD 631

  Fly   756 FGLRTLTTPSDFVRDQNYYLKLLWIAPELLPLTTIPGCCPATQRGDVYSFGIILEEIVNRGGPYQ 820
            ||..::..|.          |.||.|||.|...||      :|:||||||.||.:||:.|...:.
  Rat   632 FGCNSILPPK----------KDLWTAPEHLRQATI------SQKGDVYSFSIIAQEIILRKETFY 680

  Fly   821 --EARQQMDVHTILHKVRQCNGFRPLIRERECPPDL---------LE---LMEKCWADNQEERPT 871
              ..|.|.:.   :.:|....|.:|.      .|||         ||   |::.||.::.|:||.
  Rat   681 TLSCRDQNEK---IFRVENSYGTKPF------RPDLFLETADEKELEVYLLVKSCWEEDPEKRPD 736

  Fly   872 FSTIRSNIRTIMKGF----CENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILP 932
            |..|.|.:..|...|    .|:.||.|:.|::.|:.|||.||||:|:....|:.|.:.|.:.:||
  Rat   737 FKKIESTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADHLNFMLLP 801

  Fly   933 RPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYK 997
            |.|.:.|....:||||.:..||||||||||||.:|..|:||:||:.|||:|.:||:|:..:||||
  Rat   802 RLVVKSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDQIVDHHDVYK 866

  Fly   998 VETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGV 1062
            ||||||||:|.||||..||::||.:|:.||||||..:.:|.|.|.|...:.||||:|||...|||
  Rat   867 VETIGDAYVVASGLPMRNGNRHAVDISKMALDILSFMGTFELEHLPGLPVWIRIGVHSGPCAAGV 931

  Fly  1063 VGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFG-TFQMEQRGDVELKGKGTVTT 1126
            ||.|||.||||||||||||||||||.|.:||:||:|.|||.:.. .|..|.||:..|||:||.||
  Rat   932 VGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTIAILRRTDCQFLYEVRGETYLKGRGTETT 996

  Fly  1127 YWLNSTSEGEARPPTP 1142
            |||....:.|...|||
  Rat   997 YWLTGMKDQEYNLPTP 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	91/439 (21%)
		ANF_receptor	107..479	CDD:279440	84/405 (21%)
		PKc_like	616..885	CDD:304357	91/294 (31%)
		TyrKc	627..877	CDD:197581	89/275 (32%)
		HNOBA	<882..939	CDD:285003	23/60 (38%)
		CYCc	918..1109	CDD:214485	111/191 (58%)
		Guanylate_cyc	945..1131	CDD:278633	117/186 (63%)
Gucy2c	NP_037302.1	Periplasmic_Binding_Protein_Type_1	34..414	CDD:299141	94/454 (21%)
		PKc_like	479..749	CDD:304357	95/313 (30%)
		STYKc	501..744	CDD:214568	88/271 (32%)
		CYCc	787..978	CDD:214485	111/190 (58%)
		Guanylate_cyc	814..1001	CDD:278633	117/186 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820