DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and Gucy1b2

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_001257640.1	Gene:	Gucy1b2 / 25206	RGDID:	2770	Length:	742	Species:	Rattus norvegicus

Alignment Length:	865	Identity:	230/865 - (26%)
Similarity:	335/865 - (38%)	Gaps:	290/865 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 SEYWGDKGWEMKDEHDAKAR------KAYEALLRVSLLQPTSPKFQDFADNVRENALYDYNYTFG 406
            :|.:|::.|| |.:..|:.:      ..|:.::.:.|:|.        |..|.:.::......||
  Rat    14 TEKFGEETWE-KLKASAEVQDVFMTYTVYDDIITIKLIQE--------ACKVLDVSMEAILKLFG 69

  Fly   407 EGEEVNFFIGAFYDGVYLLGMALNETLTEGGDIRDGVN----ITRRMWN----RTFEGITG---- 459
            |    .||......|...:...|...|||..:..|.::    ::.:..|    |..||..|
  Rat    70 E----YFFKFCKMSGYDRMLRTLGGNLTEFIENLDALHSYLALSYQEMNAPSFRVEEGADGAMLL 130

  Fly   460 HVRIDDNG-----------------DRDADYSILDLD---PINGKFSVVAHYSGVHKVYSAVHGK 504
            |...|.:|                 |.|...||||::   ...||...|. :..|.|.:..:.|.
  Rat   131 HYYSDRHGLCHIVPGIIEAVAKDFFDTDVAMSILDMNEEVERTGKKEHVV-FLVVQKAHRQIRGA 194

  Fly   505 KIHWPGGREEPPPDVPPCGFLGNSTDCVGNFSTIMYSVFGLLLFLGLVFL--VICLLQKQMKLSK 567
            |...|.|.|:...|                    ..::.|.||.:...:|  .:|..:|.
  Rat   195 KASRPQGSEDSQAD--------------------QEALQGTLLRMKERYLNIPVCPGEKS----- 234

  Fly   568 ELNNMSWRVRPDDVLIEMGGMFGSKGGL---------QRLDV-ENISLQQFGIHSGRASIASFTS 622
                       ....:....:|| ||.|         :||.| |.:....|..|.
  Rat   235 -----------HSTAVRASVLFG-KGPLRDTFQPVYPERLWVEEEVFCDAFPFHI---------- 277

  Fly   623 LPPQVYTTIGQFKGERVAIKKVNVKKVDLTPQLLWEIKQARDVSHENTVRFVGACIDLPRPTVLI 687
                |:       .|.:.:|:..|......|.:|             |.:|.
  Rat   278 ----VF-------DEALRVKQAGVNIQKYVPGIL-------------TQKFA------------- 305

  Fly   688 LTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLK 752
            |.||                      .|:||..|.             ..:.|....|:.:||||
  Rat   306 LDEY----------------------FSIIHPQVT-------------FNISSICKFINSQFVLK 335

  Fly   753 ISDFGLRTLTTPSDFVRDQNYYLKLLWIAPELLPLTTIPGCCPATQRGDVYSFGIILEEIVNRGG 817
                                       ...|::|.                         ..:..
  Rat   336 ---------------------------TRKEMMPK-------------------------ARKSQ 348

  Fly   818 PYQEARQQMDVHTILHKVRQCNGFRPLIRERECPPDLLELMEKCWADNQEERPTFSTIRSNIRTI 882
            |..:.|.||    |..:..:|..|.       |.|.|..|.|.     :|.:...|.|..:..|
  Rat   349 PMLKLRGQM----IWMESLRCMIFM-------CSPKLRSLQEL-----EESKMHLSDIAPHDTT- 396

  Fly   883 MKGFCENLMDDLLNRMEQYANNLESLVEEK-------TRQLSLEKQRTEELLYQILPRPVAQQLM 940
                 .:|:  |||:.......|...:|:|       :..|::||::||.|||.:||..||.||.
  Rat   397 -----RDLI--LLNQQRLAEMELSCQLEKKKEELRVLSNHLAIEKKKTETLLYAMLPEHVANQLK 454

  Fly   941 AGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAY 1005
            .|..|...||.:.||.|||:|.||.:||...|:.:||.||.:||.|||:...:||||||||||||
  Rat   455 EGRKVAAGEFETCTILFSDVVTFTNICAACEPIQIVNMLNSMYSKFDRLTSVHDVYKVETIGDAY 519

  Fly  1006 LVVSGLPEPNGDKHAREIALMAL-------DILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVV 1063
            :||.|:|.| .:.||:.:|..||       :::..|:.     :|   ||||:|:|:|.|.||||
  Rat   520 MVVGGVPVP-VESHAQRVANFALGMRISAKEVMNPVTG-----EP---IQIRVGIHTGPVLAGVV 575

  Fly  1064 GKKMPHYCLFGDTVNTASRMESTGQPGKIHVS-SATKAILDKFGTFQMEQRGDVELKGKGTVTTY 1127
            |.|||.||||||||||||||||.|.|.|:|:| :|.:|:.:|  .|::.:||::|:||||.:|||
  Rat   576 GDKMPRYCLFGDTVNTASRMESHGLPSKVHLSPTAHRALKNK--GFEIVRRGEIEVKGKGKMTTY 638

  Fly  1128 W----LNST-SEGEARPPTP 1142
            :    ||:| .|...||..|
  Rat   639 FLIQNLNATEDEIMGRPSAP 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	40/185 (22%)
		ANF_receptor	107..479	CDD:279440	36/165 (22%)
		PKc_like	616..885	CDD:304357	39/268 (15%)
		TyrKc	627..877	CDD:197581	38/249 (15%)
		HNOBA	<882..939	CDD:285003	19/63 (30%)
		CYCc	918..1109	CDD:214485	101/198 (51%)
		Guanylate_cyc	945..1131	CDD:278633	99/197 (50%)
Gucy1b2	NP_001257640.1	HNOB	2..163	CDD:285002	32/161 (20%)
		HNOBA	267..453	CDD:285003	60/343 (17%)
		CYCc	432..622	CDD:214485	102/200 (51%)
		Guanylate_cyc	459..642	CDD:278633	98/193 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810