DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and Npr1

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_036745.1	Gene:	Npr1 / 24603	RGDID:	3195	Length:	1057	Species:	Rattus norvegicus

Alignment Length:	1076	Identity:	453/1076 - (42%)
Similarity:	632/1076 - (58%)	Gaps:	103/1076 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 VLMASHLDSPFDLERCGPAVDLALDEIN-KVFLKPH---NITLLKKKGSYPSCSGARAPGLAADM 153
            ||..::...|:...|.||||:|||..:. :..|.|.   .:.|...:.:...||...||..|.|:
  Rat    36 VLPLTNTSYPWSWARVGPAVELALARVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDL 100

  Fly   154 YFQDDVIAFIGPACAFALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTSGILGRIHKWKNENT 218
            .::.....|:||.|.::..||.|..|:|..|::|.         |...:..|:
  Rat   101 KWEHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLTA---------GAPALGIGV------------ 144

  Fly   219 GMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNWNHVALLVDRSELFSWTVGKNLEYGLRQEGL 283
                 |.:|...||......:|.....::.|:..|.|.||:     |::..:|.:.......|||
  Rat   145 -----KDEYALTTRTGPSHVKLGDFVTALHRRLGWEHQALV-----LYADRLGDDRPCFFIVEGL 199

  Fly   284 LSFVKE---LNGNEEEV-------YENYLKDASMYARVVILSVRGVLVRKFMLAAHSLGMTNGEW 338
            ...|:|   :..|.:|.       |...|:......||:.:.......|..||.|.:.|:|..::
  Rat   200 YMRVRERLNITVNHQEFVEGDPDHYPKLLRAVRRKGRVIYICSSPDAFRNLMLLALNAGLTGEDY 264

  Fly   339 VFLDVEIFQSEYWGDKG------WEMKDEHDAKARKAYEALLRVSLLQPTSPKFQDFADNVRENA 397
            ||..:::|.......:|      ||..|..|..||:|::|...::..:|.:|::.:|...::..|
  Rat   265 VFFHLDVFGQSLKSAQGLVPQKPWERGDGQDRSARQAFQAAKIITYKEPDNPEYLEFLKQLKLLA 329

  Fly   398 LYDYNYTFGEGEEVNFFIGAFYDGVYLLGMALNETLTEGGDIRDGVNITRRMWNRTFEGITGHVR 462
            ...:|:|..:|.: |....:|:||:.|...|:.|||.:||.:.||.|||:|||||:|:|:||:::
  Rat   330 DKKFNFTVEDGLK-NIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLK 393

  Fly   463 IDDNGDRDADYSILDLDPINGKFSVVAHYSGVHKVYSAVHGKKIHWPGGREEPPPDVPPCGFLGN 527
            ||.|||||.|:|:.|:||..|.|.||.:|:|..:...||...|::||.|  .||||||.|||...
  Rat   394 IDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQELMAVSEHKLYWPLG--YPPPDVPKCGFDNE 456

  Fly   528 STDC-VGNFSTIMYSVFGLLLFLGLV-FLVIC-LLQKQMKLSKELNNMSWRVRPDDVLIEMGGMF 589
            ...| ..:|||:  .|..|:..|.|: ||::. .:.::|:|.|||.:..||||.:|
  Rat   457 DPACNQDHFSTL--EVLALVGSLSLISFLIVSFFIYRKMQLEKELVSELWRVRWED--------- 510

  Fly   590 GSKGGLQRLDVENISLQQFGIH---SGRASIASFTSLPPQVYTTIGQF---------KGERVAIK 642
                 ||...:|. .|:..|..   |||.|  ::.||    .||.|||         ||..||:|
  Rat   511 -----LQPSSLER-HLRSAGSRLTLSGRGS--NYGSL----LTTEGQFQVFAKTAYYKGNLVAVK 563

  Fly   643 KVNVKKVDLTPQLLWEIKQARDVSHENTVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIE 707
            :||.|:::||.::|:|:|..|||.:|:..||||||.|  .|.:.||||||.||||:|:||||:|.
  Rat   564 RVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTD--PPNICILTEYCPRGSLQDILENESIT 626

  Fly   708 LDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGLRTLTTPSDFVRDQN 772
            |||.||.||.:||||||.:|||..:.:||.|:|.||::||||||||:|:||.:...|..   :|.
  Rat   627 LDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEP---EQG 688

  Fly   773 Y--YLKLLWIAPELLPLTTIPGCCPATQRGDVYSFGIILEEIVNRGGPYQEARQQMDVHTILHKV 835
            :  :.|.||.|||||.:.:.|  ...:|.||||||||||:||..|.|.:......:....|:.:|
  Rat   689 HTLFAKKLWTAPELLRMASPP--ARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERV 751

  Fly   836 RQCN--GFRPLIRERECPPDLLELMEKCWADNQEERPTFSTIRSNIRTIMKGFCENLMDDLLNRM 898
            .:..  .|||.:..:....:|.:||::|||::.:|||.|..||..:|...|....|::|:||:||
  Rat   752 TRGEQPPFRPSMDLQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRM 816

  Fly   899 EQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGF 963
            ||||||||.||||:|:....||::.|.|||||||..||:||..|:.|:.|.|.||||||||||||
  Rat   817 EQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGF 881

  Fly   964 TELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMAL 1028
            |.|.|.|:||.||..|||||:.||.:|..:||||||||||||:||||||..||..||||:|.|||
  Rat   882 TALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMAL 946

  Fly  1029 DILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIH 1093
            .:|.||.||.:||:|:.::::|||:|:|.|||||||.|||.||||||||||||||||.|:..|||
  Rat   947 ALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIH 1011

  Fly  1094 VSSATKAILDKFGTFQMEQRGDVELKGKGTVTTYWL 1129
            :||.|||:|::|..|::|.|||||:||||.|.||||
  Rat  1012 LSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWL 1047

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	124/422 (29%)
		ANF_receptor	107..479	CDD:279440	113/391 (29%)
		PKc_like	616..885	CDD:304357	126/281 (45%)
		TyrKc	627..877	CDD:197581	121/262 (46%)
		HNOBA	<882..939	CDD:285003	32/56 (57%)
		CYCc	918..1109	CDD:214485	124/190 (65%)
		Guanylate_cyc	945..1131	CDD:278633	125/185 (68%)
Npr1	NP_036745.1	PBP1_NPR_A	32..439	CDD:107380	127/434 (29%)
		ANF_receptor	50..410	CDD:279440	113/391 (29%)
		PK_GC-A_B	530..803	CDD:270944	129/285 (45%)
		TyrKc	543..797	CDD:197581	120/260 (46%)
		HNOBA	<812..857	CDD:285003	29/44 (66%)
		CYCc	836..1025	CDD:214485	124/188 (66%)
		Guanylate_cyc	863..1049	CDD:278633	125/185 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	170	1.000	Domainoid score	I3673
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37367
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	1	1.000	-	-		FOG0002376
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.680