DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and Gucy2g

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_620611.2	Gene:	Gucy2g / 245708	RGDID:	621853	Length:	1103	Species:	Rattus norvegicus

Alignment Length:	1175	Identity:	367/1175 - (31%)
Similarity:	571/1175 - (48%)	Gaps:	146/1175 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LAGLNASDAGLEQRMY---ERSRESKSTQLSRYT-------EVGEMGSTMRVYNVGVLMASHLDS 101
            :|....|:..||.|.|   |......|..|:.:.       |..::       .||.....::..
  Rat     4 MASRARSEPPLEHRFYGGAESHAGHSSLVLTLFVVMLMTCLEAAKL-------TVGFHAPWNISH 61

  Fly   102 PFDLERCGPAVDLALDEINKVFLKPHNITLLKKKGSYPSCSGARAPGLAA--DMYFQDDVIAFIG 164
            ||.::|.|..:.:|:|::|...:.|.|   |..:.:|.:.:......|||  |...::.:...||
  Rat    62 PFSVQRLGAGLQIAVDKLNSEPVGPGN---LSWEFTYTNATCNAKESLAAFIDQVQREHISVLIG 123

  Fly   165 PACAFALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTSGILGRIHKWKNENTGMFKDKSKYPT 229
            |||..|.|.:..||:.|:.|:...:|......:             |.|.:....:...|.:..|
  Rat   124 PACPEAAEVIGLLASEWDIPLFDFVGQMTALED-------------HFWCDTCVTLVPPKQEIGT 175

  Fly   230 LTRMSYCQCRLILVFASVIRQFNWNHVALLVDRSELFSWTVGKNLEYGLRQEGLLSF-----VKE 289
            :.|.|             ::...|.::.:....|...||.....|...:..|..|.|     |:.
  Rat   176 VLRES-------------LQYLGWEYIGVFGGSSAGSSWGEVNELWKAVEDELQLHFTITARVRY 227

  Fly   290 LNGNEEEVYENYLKDASMYARVVILSVRGVLVRKFMLAAHSLGMTNGEWVFLDVEIFQSEYWGDK 354
            .:|:.:.:.|. |:..|..|||:||.......:..:.||..||:.:.|:|||.::..:..:|.:
  Rat   228 SSGHSDLLQEG-LRSMSSVARVIILICSSEDAKHILQAAEDLGLNSREFVFLLLQQLEDSFWKE- 290

  Fly   355 GWEMKDEHDAKARKAYEALLRVSLLQPT----SPKFQDFADNVRENALY-DYNYTFGEGEEVNFF 414
              .:.::...:..|.||:   |.|:.|:    |....||...|.:.... .:..:....::|:.:
  Rat   291 --VLAEDKVTRFPKVYES---VFLIAPSTYGGSAGDDDFRKQVYQRLRRPPFQSSISSEDQVSPY 350

  Fly   415 IGAFYDGVYLLGMALNETLTEGGDIRDGVNI--TRRMWNRTFEGITGHVRIDDNGDRDADYSILD 477
            ....:|.:.|....:.|.:....|.|||..:  |.|....|.:||||.|.:|..|.|..|||:..
  Rat   351 SAYLHDALLLYAQTVEEMMKAEKDFRDGRQLISTLRADQVTLQGITGPVLLDAQGKRHMDYSVYA 415

  Fly   478 LDPI-NG-KFSVVAHYSGVHKVY---------SAVHGKKIHWPGGREEPPPDVPPCGFLGN---- 527
            |... || :|....||....||.         |..||..          |...|.|||..:
  Rat   416 LQKSGNGSRFLPFLHYDSFQKVIRPWRDDLNASGPHGSH----------PEYKPDCGFHEDLCRT 470

  Fly   528 ----STDCVGNFSTIMYSVFGLLLFLGLVFLVICLLQKQMKLSKELNNMSWRVRPDDVLIEMGGM 588
                ......:.:.::.:|..|::........:.|.:.:.|:.....:..|::..|.:.:.....
  Rat   471 KPPTGAGMTASVTAVIPTVTLLVVASAAAITGLMLWRLRGKVQNHPGDTWWQIHYDSITLLPQHK 535

  Fly   589 FGSKG-GLQRLDVENISLQQFGIHSGRASIASFTSLPPQVYTTIGQFKGERVAI------KKVNV 646
            ...:| .:.|.:|.|.|..:.....|  |.|.........|..:|.::|..||:      .:..:
  Rat   536 PSHRGTPMSRCNVSNASTVKISADCG--SFAKTHQDEELFYAPVGLYQGNHVALCYIGEEAEARI 598

  Fly   647 KKVDLTPQLLWEIKQARDVSHENTVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWN 711
            ||    |.:|.|:....::.|||.|.|.|.|.:  .|.:.|:|:.|.:|||||||.|...|:||.
  Rat   599 KK----PTVLREVWLMCELKHENIVPFFGVCTE--PPNICIVTQCCKKGSLKDVLRNSDHEMDWI 657

  Fly   712 FRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGL---RTLTTPSDFVRDQNY 773
            |::|.::|||.||.:||.|.:.:||.|:..|||:|....||::.|||   :..:|...:.::...
  Rat   658 FKLSFVYDIVNGMLFLHGSPLRSHGNLKPSNCLVDSHMQLKLAGFGLWEFKHGSTCRIYNQEATD 722

  Fly   774 YLKLLWIAPELLPLTTIPGCCPATQRGDVYSFGIILEEIVNR--GGPYQEARQQMDVHTILHKVR 836
            :.:|.|.|||||.|..:|  ...|.:||||||.|:|.:::::  .||::      |:.....::.
  Rat   723 HSELYWTAPELLRLRELP--WSGTPQGDVYSFAILLRDLIHQQAHGPFE------DLEAAPEEII 779

  Fly   837 QCNGFRPLIRERECP----PDLLE---------LMEKCWADNQEERPTFSTIRSNIRTIMKGFCE 888
            .|      |::...|    |.|||         |:..|||::.|:||.|.:|:..:|........
  Rat   780 SC------IKDSRAPVPLRPSLLEDKGDERIVALVRACWAESPEQRPAFPSIKKTLREASPRGRV 838

  Fly   889 NLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSV 953
            :::|.::.::|.||::||.:|||:|.||..||::.|:||..:||..|.:||:||..||||.|.||
  Rat   839 SILDSMMGKLEMYASHLEEVVEERTCQLVAEKRKVEKLLSTMLPSFVGEQLIAGKSVEPEHFESV 903

  Fly   954 TIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDK 1018
            ||:||||||||:||:.|||:.||..||||||.||..|..:||||||||||||:|.||||..||.:
  Rat   904 TIFFSDIVGFTKLCSLSSPLQVVKLLNDLYSLFDHTIQTHDVYKVETIGDAYMVASGLPIRNGAQ 968

  Fly  1019 HAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRM 1083
            ||.|||.|:|.:|...::|.:.|.||.::::|||:|:|.|.|||||..||.|||||||||.||||
  Rat   969 HADEIATMSLHLLSVTTNFQIGHMPEERLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRM 1033

  Fly  1084 ESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVELKGKGTVTTYWLNSTSEGEARPPTPQILTTD 1148
            ||:..|.:||||.:|...|...|.:.:::||.:.:||||..||:||  |.:.....|.|: .|.:
  Rat  1034 ESSSLPLRIHVSQSTARALLVAGGYHLQKRGTISVKGKGEQTTFWL--TGKDGFAVPLPE-FTEE 1095

  Fly  1149 EVPFP 1153
            |...|
  Rat  1096 EAKVP 1100

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	100/421 (24%)
		ANF_receptor	107..479	CDD:279440	90/385 (23%)
		PKc_like	616..885	CDD:304357	95/292 (33%)
		TyrKc	627..877	CDD:197581	92/273 (34%)
		HNOBA	<882..939	CDD:285003	20/56 (36%)
		CYCc	918..1109	CDD:214485	112/190 (59%)
		Guanylate_cyc	945..1131	CDD:278633	110/185 (59%)
Gucy2g	NP_620611.2	PBP1_GC_G_like	50..439	CDD:107367	102/424 (24%)
		ANF_receptor	66..417	CDD:279440	90/386 (23%)
		PK_GC	558..832	CDD:270894	96/295 (33%)
		CYCc	868..1058	CDD:214485	112/189 (59%)
		Guanylate_cyc	895..1081	CDD:278633	110/187 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820