DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3216 and Phlpp2

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_001116066.2	Gene:	Phlpp2 / 244650	MGIID:	2444928	Length:	1355	Species:	Mus musculus

Alignment Length:	673	Identity:	132/673 - (19%)
Similarity:	234/673 - (34%)	Gaps:	191/673 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   530 DCVGNFSTIMYSVFGLLLF---LGLVFLVICLLQKQMKLSKELNNMSWRVRPDDVLIEMGGMFGS 591
            |.:..||.:.    ||.|.   |||..:::|.:....:||...|..      .|:..::|.:
Mouse   325 DTLHKFSQLK----GLNLSHNKLGLFPVLLCEISTLTELSLSCNGF------HDLPSQIGKL--- 376

  Fly   592 KGGLQRLDVENISLQQFGIHSGRASIASFTSLPPQV-----YTTIGQFKGERVAIKKVNVKKVDL 651
                  |:::.:||...|:          |:||.::     .|::|           ::......
Mouse   377 ------LNLQTLSLDGNGL----------TALPDELGNLRQLTSLG-----------ISFNDFRH 414

  Fly   652 TPQLLWEIKQARDVSHENTVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSL 716
            .|::|.::.....|:....           |..||.|      |:|..:.:.:.::|..|...::
Mouse   415 IPEVLEKLTMLDKVAMAGN-----------RLEVLNL------GALTRMSQVKHVDLRMNHLKTV 462

  Fly   717 IHDIVKGM----------NYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGLRTLTTPSDFVRDQ 771
            |.:.::|.          |.|.:.|:::...|...:|..:....|.:|.|.||||....:.:...
Mouse   463 ITENMEGNKHITHMDLRDNQLTDLDLSSLCSLEQLHCERNQLRELTLSGFSLRTLYASWNRLTAV 527

  Fly   772 NYY-----LKLLWIAPELLPLTTIPGCCP--ATQRGDVYSFGI---ILEEIVNRGGPYQEARQQM 826
            |.|     |..|.::..||.      |.|  |.:...:....|   :|.|:..|.......|:.|
Mouse   528 NVYPVPSLLTSLELSQNLLE------CVPDWACEAKKLEILDISHNLLTEVPMRILSSLSLRKLM 586

  Fly   827 DVHTILHKVRQCNGFRPLIRERECPPDLLELMEKCWADNQEERPTFSTIRSNIRTIMKGFCENLM 891
            ..|..:|.:       |.:.| ..|.::|::          :..|.|.:...:      |.:.|.
Mouse   587 VGHNHIHVL-------PALVE-HIPLEVLDI----------QHNTLSRLPDTL------FSKALN 627

  Fly   892 DDLLNRMEQYANNLESLV-----EEKTRQLSLEKQRTEELLYQILPRPVA--------------Q 937
               |..:...||:||||.     ||....|.|....:..|..|.:|..|.              |
Mouse   628 ---LRYLNASANSLESLPSACAGEESLSVLQLLYLTSNLLTDQCIPVLVGHPHLRVLHLANNQLQ 689

  Fly   938 QLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNF--LNDLYSTFDRIIGFYDVYKVET 1000
            ...|..|.:.|:...:.:..:.:...        |..:.|.  |:.|.:..:.|..|.::.::..
Mouse   690 TFPASKLNKLEQLEELNLSGNKLTAI--------PTTIANCKRLHTLVAHANNISIFPEILQLPQ 746

  Fly  1001 IGDAYLVVSGLPE---PNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGV 1062
            |....|..:.|.|   |    .|....|..|| |...::..|.||       .:.|.|......:
Mouse   747 IQFVDLSCNDLTEILIP----EALPATLQDLD-LTGNTNLVLEHK-------TLDMFSHITALKI 799

  Fly  1063 VGKKMPHYCLFGDTVNTAS-----RMESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVELKGKG 1122
            ..|.:|    ..|:..|::     ..|..||..|:.||:..   :|.|.            :|.|
Mouse   800 DQKPLP----ATDSAVTSTFWSHGLAEMAGQRNKLCVSALA---MDNFA------------EGVG 845

  Fly  1123 TVTTYWLNSTSEGEARPPTPQIL 1145
            .|...:     :|:.....|::|
Mouse   846 AVYGMF-----DGDRNEELPRLL 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368
		ANF_receptor	107..479	CDD:279440
		PKc_like	616..885	CDD:304357	53/293 (18%)
		TyrKc	627..877	CDD:197581	50/274 (18%)
		HNOBA	<882..939	CDD:285003	18/75 (24%)
		CYCc	918..1109	CDD:214485	42/214 (20%)
		Guanylate_cyc	945..1131	CDD:278633	37/195 (19%)
Phlpp2	NP_001116066.2	PH_PHLPP-like	181..275	CDD:270131
		leucine-rich repeat	285..305	CDD:275380
		leucine-rich repeat	306..332	CDD:275380	2/6 (33%)
		LRR_RI	309..548	CDD:238064	55/285 (19%)
		LRR_8	354..412	CDD:290566	14/93 (15%)
		leucine-rich repeat	356..378	CDD:275380	5/36 (14%)
		leucine-rich repeat	379..401	CDD:275380	6/31 (19%)
		leucine-rich repeat	402..424	CDD:275380	4/32 (13%)
		LRR_8	425..483	CDD:290566	12/74 (16%)
		leucine-rich repeat	425..448	CDD:275380	7/39 (18%)
		LRR_RI	447..714	CDD:238064	60/299 (20%)
		leucine-rich repeat	449..472	CDD:275380	4/22 (18%)
		leucine-rich repeat	474..493	CDD:275380	3/18 (17%)
		leucine-rich repeat	494..513	CDD:275380	4/18 (22%)
		leucine-rich repeat	514..535	CDD:275380	6/20 (30%)
		LRR_8	536..592	CDD:290566	14/61 (23%)
		leucine-rich repeat	536..558	CDD:275380	7/27 (26%)
		leucine-rich repeat	559..581	CDD:275380	4/21 (19%)
		leucine-rich repeat	582..597	CDD:275380	4/21 (19%)
		LRR_8	604..664	CDD:290566	16/78 (21%)
		leucine-rich repeat	604..627	CDD:275380	4/38 (11%)
		leucine-rich repeat	628..653	CDD:275380	9/24 (38%)
		leucine-rich repeat	654..677	CDD:275380	6/22 (27%)
		LRR_8	676..735	CDD:290566	8/66 (12%)
		leucine-rich repeat	678..701	CDD:275380	3/22 (14%)
		leucine-rich repeat	702..724	CDD:275380	2/29 (7%)
		leucine-rich repeat	747..768	CDD:275380	6/24 (25%)
		PP2Cc	816..1065	CDD:238083	14/68 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900