DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and PHLPP1

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_919431.2	Gene:	PHLPP1 / 23239	HGNCID:	20610	Length:	1717	Species:	Homo sapiens

Alignment Length:	672	Identity:	119/672 - (17%)
Similarity:	207/672 - (30%)	Gaps:	249/672 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   565 LSKELNNMSWRVRPDDVLIEMGGMFGSKGGLQRLDVENISLQQFGIHSGRASIASFTSLP----- 624
            ||:|.|::                      ||.|.:.|.||..       ..:...|..|
Human  1006 LSEETNSI----------------------LQELYLTNNSLTD-------KCVPLLTGHPHLKIL 1041

  Fly   625 PQVYTTIGQFKGERVAIKKVNVKKVDLT-------PQLLWEIKQARDV-SHENTVRFVGACIDLP 681
            ...|..:..|...::| |...::::||:       |..:...::...| :|.|.:......:.||
Human  1042 HMAYNRLQSFPASKMA-KLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLP 1105

  Fly   682 RPTVLILTEYCSRGSLKDVLEN-----EAIELDWNFRMSLIHDIVKGMN---------------- 725
            ....:.|:  |:..|...:.||     :.::|..|.|:.|.|..::.:|
Human  1106 EIKCVDLS--CNELSEVTLPENLPPKLQELDLTGNPRLVLDHKTLELLNNIRCFKIDQPSTGDAS 1168

  Fly   726 -----YLHNSDVAAHGKLRSC------NCLIDGRFVLKISDFGLRTLTTPSDFVRDQNYYLKLLW 779
                 :.|....|:..|.:.|      |...|.|..|    :|:        |..|:|..:
Human  1169 GAPAVWSHGYTEASGVKNKLCVAALSVNNFCDNREAL----YGV--------FDGDRNVEV---- 1217

  Fly   780 IAPELLPLTTIPGCCPATQRGDVYSFGIILEEIVNRGGPYQEARQQMD--VHTILHKVR------ 836
              |.||..|               ...|:.||:       |:.:.:.:  |:|.:...|
Human  1218 --PYLLQCT---------------MSDILAEEL-------QKTKNEEEYMVNTFIVMQRKLGTAG 1258

  Fly   837 -QCNGFRPLIRERECPPDLLELMEKCWADNQEERP--TFSTIRSNIRTIMKGFCEN--------- 889
             :..|...|...:..|.|                |  :|:...:|:.......|.|
Human  1259 QKLGGAAVLCHIKHDPVD----------------PGGSFTLTSANVGKCQTVLCRNGKPLPLSRS 1307

  Fly   890 -LM--DDLLNRMEQY-----ANNLESLVEEKTRQLSLEKQRTEELLY-QILPRPVAQQLMAGDLV 945
             :|  ::.|.|::|:     .:...:.|.|.||.|..      ..|: .::|||..|.::   |.
Human  1308 YIMSCEEELKRIKQHKAIITEDGKVNGVTESTRILGY------TFLHPSVVPRPHVQSVL---LT 1363

  Fly   946 EPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSG 1010
            ..:||.        |:|..                          |.:|...||   :|...|..
Human  1364 PQDEFF--------ILGSK--------------------------GLWDSLSVE---EAVEAVRN 1391

  Fly  1011 LPEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVC------AGVVGKKMPH 1069
            :|:          ||.|...|..::.....|.....:.:::.:...|.|      .|.|....|.
Human  1392 VPD----------ALAAAKKLCTLAQSYGCHDSISAVVVQLSVTEDSFCCCELSAGGAVPPPSPG 1446

  Fly  1070 YCLFGDTVNTASR---MESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVELKGKGTVTTYWLNS 1131
              :|..:||...:   .:..|.|..  .|.....|..:..|.:|...               :.|
Human  1447 --IFPPSVNMVIKDRPSDGLGVPSS--SSGMASEISSELSTSEMSSE---------------VGS 1492

  Fly  1132 TSEGEARPPTPQILTTDEVPFP 1153
            |:..|   |.|..|:.:...:|
Human  1493 TASDE---PPPGALSENSPAYP 1511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368
		ANF_receptor	107..479	CDD:279440
		PKc_like	616..885	CDD:304357	55/324 (17%)
		TyrKc	627..877	CDD:197581	52/300 (17%)
		HNOBA	<882..939	CDD:285003	16/74 (22%)
		CYCc	918..1109	CDD:214485	35/200 (18%)
		Guanylate_cyc	945..1131	CDD:278633	30/194 (15%)
PHLPP1	NP_919431.2	leucine-rich repeat	1107..1129	CDD:275380	5/23 (22%)
		PP2Cc	1168..1420	CDD:214625	63/363 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1458..1510		12/71 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1673..1717
		PDZ-binding, required for interaction with SLC9A3R1. /evidence=ECO:0000269\|PubMed:21804599	1715..1717
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..118
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..156
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..470
		PH_PHLPP-like	535..631	CDD:270131
		PH	555..636	CDD:278594
		LRR_RI	625..929	CDD:238064
		LRR_8	638..703	CDD:290566
		LRR 1	638..659
		leucine-rich repeat	641..661	CDD:275380
		LRR 2	661..682
		leucine-rich repeat	662..692	CDD:275380
		LRR 3	692..712
		leucine-rich repeat	693..738	CDD:275380
		LRR_8	714..770	CDD:290566
		LRR 4	715..736
		LRR 5	738..760
		leucine-rich repeat	739..761	CDD:275380
		LRR 6	761..783
		leucine-rich repeat	762..784	CDD:275380
		LRR 7	784..804
		leucine-rich repeat	785..808	CDD:275380
		LRR 8	808..831
		leucine-rich repeat	810..832	CDD:275380
		LRR_RI	814..1074	CDD:238064	18/97 (19%)
		LRR 9	832..853
		leucine-rich repeat	833..853	CDD:275380
		leucine-rich repeat	854..895	CDD:275380
		LRR 10	873..894
		LRR 11	895..916
		leucine-rich repeat	896..918	CDD:275380
		LRR 12	918..939
		leucine-rich repeat	919..941	CDD:275380
		LRR 13	941..962
		leucine-rich repeat	942..963	CDD:275380
		LRR_8	962..1024	CDD:290566	8/39 (21%)
		LRR 14	963..984
		leucine-rich repeat	964..987	CDD:275380
		LRR 15	987..1008		1/1 (100%)
		leucine-rich repeat	988..1011	CDD:275380	3/4 (75%)
		LRR 16	1013..1033		6/48 (13%)
		LRR_8	1014..1072	CDD:290566	14/65 (22%)
		leucine-rich repeat	1014..1037	CDD:275380	7/29 (24%)
		LRR 17	1037..1058		3/21 (14%)
		leucine-rich repeat	1038..1061	CDD:275380	4/23 (17%)
		LRR 18	1061..1082		3/20 (15%)
		Interaction with SLC9A3R1. /evidence=ECO:0000269\|PubMed:21804599	1076..1205		24/130 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900