DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and Npr2

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_776149.1	Gene:	Npr2 / 230103	MGIID:	97372	Length:	1047	Species:	Mus musculus

Alignment Length:	1126	Identity:	454/1126 - (40%)
Similarity:	619/1126 - (54%)	Gaps:	176/1126 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 RVYNVGVLMASH-LDSPFDLERCGPAVDLALDEINKVFLKPHNITLLKKK--GSYPSCSGARAPG 148
            |...:.|::..| |...:...|.||||.||::.:.:..  |.::..:..:  |   :||...||.
Mouse    23 RNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRAL--PVDLRFVSSELDG---ACSEYLAPL 82

  Fly   149 LAADMYFQDDVIAFIGPACAFALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTSGILGRIHKW 213
            .|.|:....|....:||.|.:....|||.|::|..|::|..           .|.||...
Mouse    83 RAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLLTAG-----------AVASGFAA----- 131

  Fly   214 KNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNWNHVALLV-------DRSELFSWTV- 270
            |||:         |.||.|......:|.....::...|||...|.|:       ||...|  |:
Mouse   132 KNEH---------YRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHYF--TIE 185

  Fly   271 -------GKNLEYGLRQEGLLSFVKELNGNEEEVYENYLKDASMYARVVILSVRGVLVRKFMLAA 328
                   |.||..   |..:  :.:|..|.|:..:  :::   ...|:|.:.....::.:.:|.|
Mouse   186 GVFEALQGSNLSV---QHQV--YAREPGGPEQATH--FIR---ANGRIVYICGPLEMLHEILLQA 240

  Fly   329 HSLGMTNGEWVFLDVEIFQSEY-----------WGDKGWEMKDEHDAKA-RKAYEALLRVSLLQP 381
            ....:|||::||..:::|....           |.|.    :.:..|:| |:|::.:|.::..:|
Mouse   241 QRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDN----RTQEQAQALREAFQTVLVITYREP 301

  Fly   382 TSPKFQDFADNVRENALYDYNYTFGEGEE-----VNFFIGAFYDGVYLLGMALNETLTEGGDIRD 441
            .:|::|:|.:.:...|..|:      |.|     :|...|.||||:.|....||||:.|||...|
Mouse   302 PNPEYQEFQNRLLIRAREDF------GVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTRED 360

  Fly   442 GVNITRRMWNRTFEGITGHVRIDDNGDRDADY---SILDLDPINGKFSVVAHYSGVHK-VYSAVH 502
            |:.|..:|..|.:.|:||.|.:|.|.||:.|:   ::.|||  :|.|...|||||..| ::..
Mouse   361 GLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLD--SGDFQPAAHYSGAEKQIWWT-- 421

  Fly   503 GKKIHWPGGREEPPPDVPPCGFLGNSTDC------------VGNFST-IMYSVFGLLLFLGLVFL 554
            |:.|.|..|  .||.|.|||.|..:...|            :|...| ||:.|...|:|
Mouse   422 GRPIPWVKG--APPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGVTFIMFGVSSFLIF------ 478

  Fly   555 VICLLQKQMKLSKELNNMSWRVRPDDVLIEMGGMFGS-----KGGLQRLDVENISLQQFGIHSGR 614
                  :::.|.|||.:|.||:|.:::      .||:     ||...||   .:||:.
Mouse   479 ------RKLMLEKELASMLWRIRWEEL------QFGNSDRYHKGAGSRL---TLSLRG------- 521

  Fly   615 ASIASFTSLPP-----QVYTTIGQFKGERVAIKKVNVKKVDLTPQLLWEIKQARDVSHENTVRFV 674
               :|:.||..     |::...|.|||..||||.||.|:::||.|:|:|:|..|||...:..||:
Mouse   522 ---SSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFI 583

  Fly   675 GACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLR 739
            |||||  .|.:.|:||||.||||:|:|||::|.|||.||.|||:|:||||.:||||.:::||.|:
Mouse   584 GACID--PPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLK 646

  Fly   740 SCNCLIDGRFVLKISDFGL---RTLTTPSDFVRDQNYYLKLLWIAPELL---PLTTIPGCCPATQ 798
            |.||::|.||||||:|:||   |:...|.|   ....|.|.||.|||||   ||.|     ...|
Mouse   647 SSNCVVDSRFVLKITDYGLASFRSTAEPDD---SHALYAKKLWTAPELLSGNPLPT-----TGMQ 703

  Fly   799 RGDVYSFGIILEEIVNRGGPYQEARQQMDVHTILHKVRQCNG----FRPLIRERECPPDLLELME 859
            :.|||||.|||:||..|.||:......:....|:.|||  ||    |||.|...:...:|:.|||
Mouse   704 KADVYSFAIILQEIALRSGPFYLEGLDLSPKEIVQKVR--NGQRPYFRPSIDRTQLNEELVLLME 766

  Fly   860 KCWADNQEERPTFSTIRSNIRTIMKGFCENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTE 924
            :|||.:..|||.|..|:..||...|....:::|:||.||||||||||.||||:|:....||::.|
Mouse   767 RCWAQDPTERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAE 831

  Fly   925 ELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRI 989
            .|||||||..||:||..|:.|:.|.|.|||||||||||||.|.|.|:||.||..|||||:.||.|
Mouse   832 ALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAI 896

  Fly   990 IGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMH 1054
            |..:||||||||||||:||||||..||.:||.|||.|||.:|.|||||.:||:|..::::|||:|
Mouse   897 IDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVH 961

  Fly  1055 SGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVELK 1119
            :|.|||||||.|||.||||||||||||||||.||..||||||.||..||:.|.||:|.|||||:|
Mouse   962 TGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMK 1026

  Fly  1120 GKGTVTTYWLNSTSEGEARPP 1140
            |||.:.||||....:|   ||
Mouse  1027 GKGKMRTYWLLGEQKG---PP 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	119/443 (27%)
		ANF_receptor	107..479	CDD:279440	107/408 (26%)
		PKc_like	616..885	CDD:304357	132/283 (47%)
		TyrKc	627..877	CDD:197581	126/259 (49%)
		HNOBA	<882..939	CDD:285003	31/56 (55%)
		CYCc	918..1109	CDD:214485	128/190 (67%)
		Guanylate_cyc	945..1131	CDD:278633	129/185 (70%)
Npr2	NP_776149.1	PBP1_NPR_B	26..421	CDD:380607	120/448 (27%)
		PK_GC-A_B	518..792	CDD:270944	134/295 (45%)
		HNOBA	<798..846	CDD:369471	30/47 (64%)
		CYCc	825..1009	CDD:214485	125/183 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3640
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	1	1.000	-	-		FOG0002376
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.680