Protein Alignment CG3216 and gcy-37

DIOPT Version :10

• Sequence 1: NP_726013.2
• Gene: CG3216 / 37376
• FlyBaseID: FBgn0034568
• Length: 1161
• Species: Drosophila melanogaster
• Sequence 2: NP_500171.2
• Gene: gcy-37 / 191658
• WormBaseID: WBGene00001557
• Length: 708
• Species: Caenorhabditis elegans
• Alignment Length: 679
• Identity: 154/679 - (22%)
• Similarity: 258/679 - (37%)
• Gaps: 193/679 - (28%)

  Fly   525 LGNSTDCVGNFSTIMYSVFGLLLF-----LGLVFLVICLLQKQMKLSKELNNMSWRVRPDDVLIE 584
            ||.|.|       .|:.::|..|.     .|...::.|:.....:....||:|.:.:.......|
 Worm    59 LGLSVD-------DMWEMYGEFLITHACETGWQKMLFCMANNLQEFLDNLNSMHYFIDQIAFKSE 116

  Fly   585 MGG------MFGSKG-----------------GLQR--------LDVENISLQ--QFGIHSGRAS 616
            |.|      .||..|                 ||.|        :||:...|:  |....||...
 Worm   117 MKGPTFQCEPFGESGLKLHYFSFRQGLFPIVKGLVRKTARTLFEMDVKVCMLERNQERRKSGMVE 181

  Fly   617 IASFTSLPPQVYTTIGQFKGERVAIKKVNVKKVDLTPQLLWEIKQARDVSHENTVRFVGACIDLP 681
            ...|:..|...:.     ||:|:..|..|.|..:..|.....
 Worm   182 HVIFSVEPDDNHR-----KGKRLFHKFRNTKTTENAPSFTLS----------------------- 218

  Fly   682 RPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLID 746
             .|:|:        .|:|........:.:|.:|.:.|..:    ||          ||...  ::
 Worm   219 -STILV--------GLRDFKNIFPYHVCFNKQMIIEHIGI----YL----------LREYG--LE 258

  Fly   747 GRFVLKISDFGLRTLTTPSDF---VRDQNYYLKLLWIAPELLPLTTIPGCCPATQRGDVYSFGII 808
            .:..||:||  |..|..|||.   .::...||..|:|.
 Worm   259 NKKTLKVSD--LMQLVQPSDIQLTYKNVLSYLNTLFIF--------------------------- 294

  Fly   809 LEEIVNRGGPYQEARQQMDVHTILHKVRQ--CNGF-RPLIRERE-------------CPP----- 852
                            |:..|:..::|::  ...| :||:.:.|             |.|
 Worm   295 ----------------QLKHHSKRNEVQEGSSEAFQQPLVLKGEMMPINDGNSIIFICSPHVTTV 343

  Fly   853 -DLLELMEKCWADNQEERPTFSTIRSNIRTIMKGFCENLMDDLLNRMEQYANNLESLVEEKTRQL 916
             |:|.|  |.:.   .:.|.....|..:.......|:.   :|..::|:....::.:.||    |
 Worm   344 RDILNL--KLYI---SDMPMHDATRDLVMLNQSRICQM---ELNKKLEETMKKMKKMTEE----L 396

  Fly   917 SLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLND 981
            .::|.:|:.||::.:|..:|:.|.|...|..:|||..::.|:||..|..:....||.:::..:.|
 Worm   397 EVKKSQTDRLLFEFVPPVIAEALRAAKTVPAQEFSDCSVIFTDIPDFFTISVNCSPTEIITVVTD 461

  Fly   982 LYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLRH----K 1042
            |:..|||||..:..|||.::.|:||:|.|:|..| ..|..:...:||.:|     |..:.    |
 Worm   462 LFHRFDRIIEKHKGYKVLSLMDSYLIVGGVPNAN-QYHCEDSLNLALGLL-----FEAKQVVVPK 520

  Fly  1043 PEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKF-- 1105
            .|..:::|||:|.|.|.||:|.::.|.:|:.|:|||....:.|...|||:.||:|.:.::.|.
 Worm   521 LERSVRLRIGVHCGPVVAGIVSQQKPRFCVLGNTVNVTKSICSHSSPGKVLVSNAVRTMVTKHLK 585

  Fly  1106 GTFQMEQRGDVELKGKGTVTTYWLNSTSE 1134
            ..|.....|.:||: .|.|.|::|....:
 Worm   586 SIFVFNANGYLELQ-SGKVLTHFLEKNEK 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_GC-like	90..501	CDD:380575
		Protein Kinases, catalytic domain	616..885	CDD:473864	48/293 (16%)
		HNOBA	<891..939	CDD:462234	11/47 (23%)
		CYCc	918..1109	CDD:214485	65/196 (33%)
gcy-37	NP_500171.2	HNOB	3..165	CDD:462233	23/112 (21%)
		HNOBA	223..419	CDD:462234	49/276 (18%)
		CYCc	400..577	CDD:214485	64/182 (35%)