DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and gcy-34

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_506319.1	Gene:	gcy-34 / 191656	WormBaseID:	WBGene00001554	Length:	686	Species:	Caenorhabditis elegans

Alignment Length:	651	Identity:	166/651 - (25%)
Similarity:	277/651 - (42%)	Gaps:	174/651 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   605 LQQFGIHSGRASIASFTSLPPQVYTTIGQFKGERVAIKKVNVKKVDLTPQLLWE------IKQAR 663
            |::.|..:|:.:|.:........|..:     :.|:|    |.||  |...:||      |..:.
Worm    26 LERSGFENGKENIVNHYYSDTDTYVLV-----DSVSI----VLKV--TKDQIWEMYGGFLITYSM 79

  Fly   664 DVSHENTVRFVG-------------------------------ACIDLPRPTVLILTEYCSRGSL 697
            ::..:..||.:.                               .|.:.|..| |:|..:..|..|
Worm    80 EIGWDELVRSMSPNLKGFLDNLDSLHYFIDHVVYKANLRGPSFRCEENPDGT-LMLHYFTGRPGL 143

  Fly   698 KDVLE---NEAIELDWNFRMSLIHDIVKGMN----YLHN---------------------SDVAA 734
            ..:::   .|..:|.:|..:||   :|:|..    :::|                     ||.:.
Worm   144 YHIVKGVVKEVAKLVFNLDISL---VVQGRTQRSVHMNNGERVEEHVIFLIKNVEEPRRDSDTST 205

  Fly   735 HGKLRSCNC----LIDGRFVLKISDFGLRTLTTPSDFVRDQNYYLKLLWIAPELLPLTTIPGCCP 795
            ...|.|...    :||....:.:.||. |.|  |..||.|::                     |.
Worm   206 TSALTSVEPDFGEIIDDNLKVSLQDFS-RAL--PYHFVLDES---------------------CR 246

  Fly   796 ATQRGD-VYSFGIILEEIVNRGGP----YQEARQQ-----------------MDVHTILHKVRQC 838
            ..|.|| :|:.  |..|::..|.|    ::..|.|                 :.|.|...:.:..
Worm   247 LVQCGDELYNH--IPNELLQPGTPILRIFEINRPQIPLDFENICNFINAVFVLQVKTSPLRKKHM 309

  Fly   839 NGFRPLIRERECPP-----DLLELMEKCWADNQEERPTFSTIR----------SNIRTIMKGFCE 888
            |......||:|...     :..||.:.|....:.:....||.:          ::|..:|: |..
Worm   310 NAMTKEEREQEVEAMEEEVESNELTQGCHLKLKGQMMMLSTKKHIIYLCSPYVTSINELMQ-FGM 373

  Fly   889 NL-------------------MDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRP 934
            .|                   :.|:...::..|||.:  :|..|.:|.:|:|:|:.:|..:|||.
Worm   374 RLTAMPLHDATRDLILLNQQRLSDVEVNLQLEANNEQ--LETMTHELEVERQKTDSILKDMLPRK 436

  Fly   935 VAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVE 999
            :|:||::|:.:||.|:.: |:.|.|:..|.::.....|.::|..||:::...|||:....|||||
Worm   437 IAKQLLSGEHLEPCEYEA-TVMFCDLPAFQQIIPVCQPKNIVKLLNEVFFKLDRIVVLRGVYKVE 500

  Fly  1000 TIGDAYLVVSGLPEPNGDKHAREIALMALDIL-RAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVV 1063
            |:.|:|:.|||:|:...: ||..:..:||.:: .|.|..:..:|..:  .:|||:|||::.||||
Worm   501 TVSDSYMTVSGIPDYTSE-HAENMCHVALGMMWEARSVMDPVNKTPF--LLRIGLHSGTIIAGVV 562

  Fly  1064 GKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVELKGKGTVTTYW 1128
            |.|||.|||||:||..||:|||.|..|||..||.|.:...:.|.|:...||.:.:||:|.|.||:
Worm   563 GTKMPRYCLFGETVTLASQMESLGVAGKIQCSSWTYSKAMETGRFEFSPRGRINVKGRGDVETYF 627

  Fly  1129 L 1129
            |
Worm   628 L 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368
		ANF_receptor	107..479	CDD:279440
		PKc_like	616..885	CDD:304357	66/374 (18%)
		TyrKc	627..877	CDD:197581	63/355 (18%)
		HNOBA	<882..939	CDD:285003	18/75 (24%)
		CYCc	918..1109	CDD:214485	78/191 (41%)
		Guanylate_cyc	945..1131	CDD:278633	77/186 (41%)
gcy-34	NP_506319.1	HNOB	3..167	CDD:285002	28/155 (18%)
		HNOBA	224..441	CDD:285003	49/245 (20%)
		CYCc	421..609	CDD:214485	79/191 (41%)
		Guanylate_cyc	453..629	CDD:278633	74/180 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810