Protein Alignment CG3216 and gcy-25

DIOPT Version :9

• Sequence 1: NP_726013.2
• Gene: CG3216 / 37376
• FlyBaseID: FBgn0034568
• Length: 1161
• Species: Drosophila melanogaster
• Sequence 2: NP_001294116.1
• Gene: gcy-25 / 191653
• WormBaseID: WBGene00001549
• Length: 1034
• Species: Caenorhabditis elegans
• Alignment Length: 1091
• Identity: 291/1091 - (26%)
• Similarity: 484/1091 - (44%)
• Gaps: 213/1091 - (19%)

  Fly   132 LKKKGSY--------PSCSGARAPGLAADMYFQDDVIAFIGPACAFALEPVARLAAYWNKPIITG 188
            :|..||:        |||........||::.:|..|...||.||....:.|:|||..|:|
 Worm    37 MKNAGSWRDHRLISLPSCHNFNGLENAANLNYQYSVDLLIGAACDEETQTVSRLALRWHK----- 96

  Fly   189 MGDQPPSSEGELTVTSGILGRIHKWKNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNW 253
                       |.::|..|..  |.|...|...|..|...|..           |..::.:...|
 Worm    97 -----------LYLSSAPLST--KEKESTTIALKPHSLAGTAE-----------VILAMCKSMKW 137

  Fly   254 NHVALLVDRSELFSWTVGKNLEYGLRQEG--LLSFVKELNG--NEEEVYENYLKDASMYARVVIL 314
            ..:.::.  ||...:|.....:....||.  .::...|.:|  |...:..:        ||.:|.
 Worm   138 KEIGIIY--SEETKYTAHAIYDMLAEQEDDLKINVFLETDGLSNTYTILHS--------ARALIS 192

  Fly   315 SVRGVLVRKFMLAAHSLGMTNGEWVFLDVEIFQSEYW-------GDKGWEMKDEHDAKARKAYEA 372
            .:..:.:.||............|:..:.|:..:||..       .:.|.|......|:.||.|.
 Worm   193 FLTTLDLSKFFKTLKENAFRPLEFSIVHVDCNKSEISNFYTYLDNNAGEEPNPISAARLRKLYR- 256

  Fly   373 LLRVSLLQPTSPKFQDFADNVRENALYDYNYTFGEGEEVNFFIGAFYDGVYLLGMALNETLTEGG 437
              .|:||:.:....:...:..::..|.. :||.       :......||:.||.   |.|...|
 Worm   257 --HVALLKNSHDDMEKTEEFAKKYGLVP-SYTL-------YKALILCDGLQLLN---NYTAPRG- 307

  Fly   438 DIRDGVNITRR---MWNRT----FEGITGHVRIDDNGDRDADYSILDLDPINGKFSVVAHYSGVH 495
                .::|.::   :||..    .:|.:|.|.|.::                          ||.
 Worm   308 ----NLSIVQQLPYLWNHVTNTETQGYSGPVFIGND--------------------------GVR 342

  Fly   496 KVYSAVH----GKKIH----------WPGGR---------------EEPPPDVPPCGFLGNSTDC 531
            ..|..:|    ||.:|          :.||.               |:.||....||:..|   .
 Worm   343 LPYYEMHMWRDGKAVHVANVKPRESDYCGGNMTKNCYEFLPSSPLLEDLPPYTSDCGYDNN---L 404

  Fly   532 VGNFSTIMYS--VFGLLLF-LGLVFLVICLLQKQMKLSKELNNMSWRVRPDDVLIEMGGMFGSKG 593
            ..:|...|.:  ||.:||. :.:.|    .||::..|   :..|.|||..|.:..:..|  ||..
 Worm   405 CSDFHVFMIAAIVFSILLIPMAIAF----YLQRKEHL---IQQMPWRVPLDSISFDDNG--GSLS 460

  Fly   594 GLQRLDVENISLQQFGIHSGRASIASFTSLPPQVYTTIGQFKGERVAIKK-VNVKKVDLTPQLLW 657
            ..:|:..         |.:.|||.:|..|.....:..:.:   ::|::|: |..:.:..:.|.:.
 Worm   461 ASRRVST---------ISTARASYSSIFSGNVAEHAIVNK---QKVSVKRHVQRRAITFSRQEME 513

  Fly   658 EIKQARDVSHENTVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVK 722
            .:.|.:.:||.|...|.|.|.: ....::::.::.:|.||:|::..:..:...||:.:.|..||.
 Worm   514 MLNQLKYMSHTNINPFTGICFN-QGSELIVMWQFTTRYSLEDLIFVKEQKFGRNFQSTFIKHIVH 577

  Fly   723 GMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGL----------RTLTTPSDFVRDQNYYLKL 777
            |:||:|||.:..||.|...||::|..:|:|::|||:          :.|...|.|..|..:| |.
 Worm   578 GINYIHNSSIKVHGALYLSNCVVDSYWVVKLTDFGIKGILKERTNHKELAPSSAFDVDAIHY-KY 641

  Fly   778 LWIAPE----LLPLTTIPGCCPATQRGDVYSFGIILEEIVNRGGPYQEARQQMD--VHTI----- 831
            |.:|||    :|.....|   ..|..||:|...:.:.:|:....|:.|.::.:.  .|.:
 Worm   642 LQLAPEHISAILEKLEEP---RGTVEGDIYQLAMCIYQILFYMRPFAERQESIKELAHLLSSQST 703

  Fly   832 --LH-KVRQCNGFRPLIRERECPPDLLELMEKCWADNQEERPTFSTIRSNIR----TIMKGFCEN 889
              || ||.:.|.|  .:|       ||.::::||......||....|...:.    ..:||   .
 Worm   704 APLHPKVPEGNSF--TMR-------LLSIIQQCWLYKPAARPALIKITDAVNREFGQDVKG---T 756

  Fly   890 LMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVT 954
            |:|.::..:::|:.|||.:|.|:||:|..:...||.||||:||:.||..:.:|..|.||:.||||
 Worm   757 LIDQMIEMIDEYSANLEQIVAERTRELEQDMSVTENLLYQLLPKSVADSIRSGKTVVPEQHSSVT 821

  Fly   955 IYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKH 1019
            :...|:..||:.|....|:.::..|.:|||:||.|:.....:|||.:|||||:.||:||.:|.:|
 Worm   822 LLVVDVCQFTKFCEAFIPVHILETLQELYSSFDNIVQKNKAFKVENVGDAYLICSGIPEMSGFRH 886

  Fly  1020 AREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRME 1084
            .|||..::|.:...:.:|.:||:|.:.:||::|:.||:|.||::|...|.:|:||||||.|.||.
 Worm   887 LREICKISLKLQAFMKTFKVRHRPSHTLQIKMGITSGAVAAGILGSTAPRFCIFGDTVNMACRMA 951

  Fly  1085 STGQPGKIHVSSAT-KAILDKFGTFQMEQRGDVELKGKGTVTTYWLNSTSE 1134
            |||.||.|.:|..| ..:::||.:|.:|:||.:::||||...|:||....:
 Worm   952 STGNPGSIQLSELTANTLMEKFPSFMLEERGMIDVKGKGACLTFWLTGEKD 1002

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	76/389 (20%)
		ANF_receptor	107..479	CDD:279440	74/372 (20%)
		PKc_like	616..885	CDD:304357	74/297 (25%)
		TyrKc	627..877	CDD:197581	71/274 (26%)
		HNOBA	<882..939	CDD:285003	23/56 (41%)
		CYCc	918..1109	CDD:214485	82/191 (43%)
		Guanylate_cyc	945..1131	CDD:278633	82/186 (44%)
gcy-25	NP_001294116.1	PBP1_iGluR_N_LIVBP_like	56..>230	CDD:107346	42/212 (20%)
		PKc_like	473..746	CDD:304357	75/289 (26%)
		SPS1	474..>736	CDD:223589	71/278 (26%)
		HNOBA	<764..805	CDD:285003	19/40 (48%)
		CYCc	790..976	CDD:214485	82/185 (44%)
		Nucleotidyl_cyc_III	812..999	CDD:299850	82/186 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910