DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and gcy-23

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_500309.3	Gene:	gcy-23 / 191652	WormBaseID:	WBGene00001548	Length:	1073	Species:	Caenorhabditis elegans

Alignment Length:	1141	Identity:	333/1141 - (29%)
Similarity:	539/1141 - (47%)	Gaps:	204/1141 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 NVGVLMASHLDSPFDLERCGPAVDLALDEINK--VFLKPHNITLLKKKGSYPSCSGARAPGLAAD 152
            ||.| ...|:.:...:......:.|:.:::.:  |.....:|.:|.:.|...|..|.   .:.||
Worm    17 NVKV-KVGHIGAVGSMRNAEKILQLSKEQLTQEGVLGNDFDIEILNQMGCGESYEGV---AVGAD 77

  Fly   153 MYFQDDVIAFIGPACAFALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTSGILGRIHKWKNEN 217
            ||....|.|||||.|...|:.||::|.:||.|::..|.                          :
Worm    78 MYHVQGVRAFIGPYCNAELDAVAKMATFWNIPVVGYMA--------------------------S 116

  Fly   218 TGMFKDKSKYPTLTRMSYCQCR-LILVFASVIRQFNWNHVALLVDRSELFSWTVGKNLEYGLRQE 281
            :..|.||:.:.||.|:|..... |....|::|:.:.||.||:..:...:....| ::.|....|.
Worm   117 SNSFADKTIFKTLARVSLRTTNSLAEAAAALIKHYGWNKVAIATNTGAVAFERV-QSFEEVFHQR 180

  Fly   282 GLLSFVKELNGNEEEVYEN--------YLKDASMYARVVILSVRGV--LVRKFMLAAHSLGMTNG 336
            | ::.|:::...|   |.|        .|::....||||:.:....  :.::||.|....||.|.
Worm   181 G-INVVRKIMLEE---YTNAKAIMNSGLLQELENSARVVVCAFSSTRDMNKEFMQAVTLSGMNNA 241

  Fly   337 E--WV--FLDVEIFQSEYW-GDKGWEMKDEHDAKAR-------KAYEALLRVSLLQPTSPKFQD- 388
            .  |:  :|.:|......| |:.|...::..|..|.       ..::.    :|:.|...:.:.
Worm   242 NYAWILPWLQLETKDMAPWLGENGEYQQNVKDHFANSFIIDDVNGFDN----TLVTPFKERLEAS 302

  Fly   389 --FADNVRENALYDYNYTFGEGEEVNFFIGAFYDGVYLLGMALNETLTEGGDIRDGVNITRRMWN 451
              ..|::....:|.|.:              .||.:.|..:|:..|:.|.|:....:| .:.:||
Worm   303 GYSTDDLEMKNIYGYIH--------------LYDALRLYALAVRATMNETGNENSYLN-GKEVWN 352

  Fly   452 R----TFEGI-------TGHVRIDDNGDRDADYS-------------ILDLDPI----------- 481
            .    ||.|:       :|.|.:||..:|...|:             :.:|:|:
Worm   353 HMRRITFPGLVSNAGVTSGTVMMDDIAERAPVYAAFYVPPNSDTVRKVCELEPVMLTNCDGTKTG 417

  Fly   482 NGKFSVVAHYSGVHKVYSAVHGKKIHWPGGREEPPPDVPPCGFLGNSTDCVGNFSTIMYSVFGLL 546
            ||.:.:        :|.....|   .||......|.|.|.|||.....|    ::|:   :.|..
Worm   418 NGCYEL--------QVTDLSTG---FWPSIDGSLPADEPACGFRNEKCD----YTTL---IIGGC 464

  Fly   547 LFLGLVFLVIC-LLQKQMKLSKELNNMSWRVRPDDVLI----EMGGMFGSKGGLQRLDVENISLQ 606
            :.|.::.|:|| .:..::..::.|.|..||:..||...    ||..|...  |..:..:.|:|:
Worm   465 IVLLIILLIICFFILSRVCENRALANTPWRIYRDDFRTIQENEMKSMLSI--GSSKTKMSNMSM- 526

  Fly   607 QFGIHS---GRASIASFTSLPPQVYTTIGQFKGERVAIKKVNVKKVDLTPQLLWEIKQARDVSHE 668
             |..|.   |..:.|||...|.:               :.:...:.||  |||.::|||   .|:
Worm   527 -FVKHHAVVGTNTHASFHLYPQR---------------RPIVFNRQDL--QLLNQMKQA---VHD 570

  Fly   669 NTVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVA 733
            |...|:|...: .:..:::|.::||||:::|::.|:.:.||..|..:.|.||..|:.|||:|.:.
Worm   571 NLNPFLGMSFN-EKEEMVVLWKFCSRGTIQDMIYNQEVSLDSKFHGAFIRDITLGLEYLHSSIIG 634

  Fly   734 AHGKLRSCNCLIDGRFVLKISDFG----------LRTLTTPS----DFVRDQNYYLKLLWIAPEL 784
            .||.|...:||||..:::|::|:|          |..::|.:    |..........||:..||:
Worm   635 YHGSLTPWSCLIDRNWMIKLTDYGIANPLERWEKLGLISTETLKEGDDKSGSAQKTSLLYQPPEM 699

  Fly   785 L-----------PLTTIPGCCPATQRGDVYSFGIILEEIVNRGGPYQEARQQMDVHTILHKVRQ- 837
            |           ..:.:.......|.||:|:||:::.||:.|..|:...   .:|..::..:|.
Worm   700 LKNKESNRTRRMDQSWVKQSQARRQMGDIYAFGMVMHEILFRALPFPNG---TNVSEVMDYIRDG 761

  Fly   838 CNGFRPLIRER-ECPPDLLELMEKCWADNQEERPTFSTIRSNIRTIM--KGFCENLMDDLLNRME 899
            ...|||.:.:| :..|||:.|:..||.:|.|.||:...:|.|....:  ||   :|:|.::..||
Worm   762 TKTFRPTVHDRTQIHPDLVALLLDCWNENPEVRPSIRRVRLNTENYLKVKG---SLVDQMMRMME 823

  Fly   900 QYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFT 964
            |||||||.||.|:|..|.....|.::||.|:||:.||.:|..|..|..:.|...|:.||||||||
Worm   824 QYANNLEKLVAERTGMLEEANVRADKLLGQLLPKYVANELKMGRSVPAKTFDMATVMFSDIVGFT 888

  Fly   965 ELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALD 1029
            .:|:.|:|::||:.||.:||.||..|..:..||||||||||::|||:||.||::|.|.|...||:
Worm   889 TICSSSTPLEVVSMLNSIYSKFDDAINKHGSYKVETIGDAYMIVSGIPEENGNEHIRNICNTALE 953

  Fly  1030 ILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHV 1094
            ::..:.::.:.|:...|::||:|:|:|:|.|||||...|.|||||||||.|||||||.:|.||.:
Worm   954 LMLLLKTYEIPHRRNVKLRIRLGIHTGTVAAGVVGLTAPRYCLFGDTVNVASRMESTSEPEKIQM 1018

  Fly  1095 SSATKAILDK-FGTFQMEQRGDVELKGKGTVTTYWL 1129
            |...:....: :..||:..||.||.||||.||:|||
Worm  1019 SQEARDFCVRYYSEFQITLRGTVEAKGKGPVTSYWL 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	99/468 (21%)
		ANF_receptor	107..479	CDD:279440	91/423 (22%)
		PKc_like	616..885	CDD:304357	80/297 (27%)
		TyrKc	627..877	CDD:197581	74/276 (27%)
		HNOBA	<882..939	CDD:285003	26/58 (45%)
		CYCc	918..1109	CDD:214485	89/191 (47%)
		Guanylate_cyc	945..1131	CDD:278633	94/186 (51%)
gcy-23	NP_500309.3	Periplasmic_Binding_Protein_Type_1	38..407	CDD:299141	93/421 (22%)
		ANF_receptor	38..385	CDD:279440	90/399 (23%)
		PK_GC	509..806	CDD:270894	87/324 (27%)
		HNOBA	<817..863	CDD:285003	22/45 (49%)
		CYCc	842..1035	CDD:214485	90/192 (47%)
		Guanylate_cyc	869..1056	CDD:278633	94/186 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910