Protein Alignment CG3216 and gcy-19

DIOPT Version :9

• Sequence 1: NP_726013.2
• Gene: CG3216 / 37376
• FlyBaseID: FBgn0034568
• Length: 1161
• Species: Drosophila melanogaster
• Sequence 2: NP_001348702.1
• Gene: gcy-19 / 191650
• WormBaseID: WBGene00001544
• Length: 1187
• Species: Caenorhabditis elegans
• Alignment Length: 1181
• Identity: 336/1181 - (28%)
• Similarity: 557/1181 - (47%)
• Gaps: 220/1181 - (18%)

  Fly    85 TMRVYNVGVLMASHLDS---PFDLERCGPAVDLALDEI-NKVFLKPHN--ITLLKKKGSYPSCSG 143
            |:|| .|..:..:.|||   |..    |.|:::|:.:: :..|:.|.:  :|:     :|..|.
 Worm    43 TIRV-GVAAVQTTELDSIGWPMS----GGAINMAIQKLRDDGFIAPFDFEVTV-----NYTECD- 96

  Fly   144 ARAPGLAADMYFQD----DVIAFIGPACAFALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTS 204
             |:.|.|..|.|..    ||:  |||.|...:|.:|.:|.|::.|
 Worm    97 -RSLGAAVGMEFMRTKRLDVV--IGPPCRDPMEIMATMATYYSTP-------------------- 138

  Fly   205 GILGRIHKWKNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNWNHVALLVDRS-ELFSW 268
             :||    |.......|.|..:||.||.:......|......::....|:.|||:.:.| :.:..
 Worm   139 -MLG----WGLVTDSKFTDTERYPYLTNIMANSLSLGFSLVKLLEMMEWDRVALVYEESAQDYPL 198

  Fly   269 TVGKNLEYGLRQEGLLS---FVKE-LNGNE--EEVYENYLKDASMYARVVILSVRGVLV-RKFML 326
            :|..::|..:.:....:   .||: |.|.:  :..|.:.|....:..|:::...:.... |:::.
 Worm   199 SVINDVETAINEYDTFAVNVVVKQALPGGDLNDAQYISVLNRIKLRCRIIVSVFQTAPTRRRYLK 263

  Fly   327 AAHSLGMTNGEWVFLDVEIFQSEYWGDKG------------------WEM--KDEHDAKARKAYE 371
            .....||.|.|:|.:.:.: :|..:|.:.                  |::  .|..:.:.::|..
 Worm   264 MIDQQGMANEEYVHILLGL-RSIGFGKQSAGLTKCELNCLSSGLAPFWDIAPDDGLNDRLKQAAT 327

  Fly   372 ALLRVSLLQPTSPKFQDFADNVRENALYDYNY----TFGEGEEV--------------------N 412
            .:|.:.|     |...|.:.:|.     |.||    |...|..|                    :
 Worm   328 RMLVMDL-----PDTMDLSTDVP-----DINYLNTFTMNCGAVVVNPPVSCATPACINASTSPPS 382

  Fly   413 FFIGAFYDGVYLLGMALNETLTEG----GDIRDGVNITRRMWNRTFEGITGHVRIDDNGDRDADY 473
            .|..:.:|..||.|:|:.....:.    .|| |.:|...::   .|.|:||.|.|:.|..|....
 Worm   383 AFARSLHDVFYLYGLAITNLYNQDPAYLNDI-DKINGALQL---NFAGLTGEVSINANNSRVPKL 443

  Fly   474 SILDLD-------------PINGKFSVVAHYSGVHKVYSAVHGKKIHWPGGREEPPPDVPPCGFL 525
            .:..|:             .:||..||...|:....::        :|.||:.  |..||.|||.
 Worm   444 MLYALNDKYDQASFMNLTYSLNGGASVSLAYTNEASLW--------YWYGGKR--PLSVPVCGFA 498

  Fly   526 GNSTDC----VGNFSTIMYSVFGLLLFLGLVFLVICL--LQKQMKLSKELNNMSWRVRPDDVLIE 584
            |  |||    |..:..:::::.|:|:| .::|::.|.  :.:|.:|.::..:..|::    .|::
 Worm   499 G--TDCPQSFVDQYGALVFAIGGVLIF-AMLFVITCFFYVMRQKRLERDRIDAEWQI----PLVK 556

  Fly   585 MGGMFGSKGGLQRLDVENISLQQFGIHSGRASIASFTSLP-PQVYTTIGQFKGERVAIKKV---- 644
            :...       .:.|.|.:|.:  .:.||.::|...:.:. ...::....|..::..:...
 Worm   557 LQAP-------PKRDKERMSKR--SLQSGPSNITDTSKMTFDNTFSNYSIFYLDKEPVLSTAHPA 612

  Fly   645 -NVKKVDLTPQLLWEIKQARDVSHENTVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIEL 708
             |:.:.|..     ...:.|.:.|||..:|||..||  .|..|.:.:.|.||||:|::......:
 Worm   613 SNLIRTDYD-----TFVRLRKLDHENVNKFVGMSID--GPEYLAVWKLCMRGSLQDIIGQGNFSI 670

  Fly   709 DWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGLRTLTTPSDFVRDQNY 773
            |..|...:|.|:.:|:.|||||.:..|..|||...|::..:..|::||||.||......::.:.
 Worm   671 DPFFMFCVIRDMAEGLKYLHNSFLHVHANLRSGTVLVNESWQAKLTDFGLGTLAEEKKPMKRRQ- 734

  Fly   774 YLKLLWIAPELLPLTTIPGCCPATQRGDVYSFGIILEEIVNRGGPYQEARQQMDVHTILHKVRQ- 837
                ||:|||::..|.:|.  ...:..|:||..:|..|::.|...:..|.::..|..|::::::
 Worm   735 ----LWMAPEVIRGTLLPH--QIEKSADIYSLAVIASEVLTRKEAWNMAERKDTVDEIVYRIKKG 793

  Fly   838 -CNGFRPLIRER--ECPPDLLELMEKCWADNQEERPTFSTIRSNIRTIM--KGFCENLMDDLLNR 897
             .|..||.:...  |...:||.|:..||::...:||:...|.:.::.:|  ||   ||||.:.|.
 Worm   794 GPNAPRPELDMDGVEINHNLLILIRDCWSEEPADRPSADVICNLLKNMMPKKG---NLMDHVFNI 855

  Fly   898 MEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVG 962
            :|.|..|||..||::|::|:.||::.:.||.::||:.||::|..|..||||.|.|||::|||:|.
 Worm   856 LEDYTTNLEVEVEDRTKELTAEKKKADVLLGRMLPKQVAERLKQGQTVEPEGFDSVTVFFSDVVK 920

  Fly   963 FTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMA 1027
            ||:|.|:.||..|||.||||||.||.||..:..||||:|||.||.|||||..||:.|.::|..::
 Worm   921 FTQLAAKCSPFQVVNLLNDLYSNFDAIIEEHGCYKVESIGDGYLCVSGLPSKNGNAHIKQIVELS 985

  Fly  1028 LDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKI 1092
            ||.:....||.:.|.|..|:::|||::||...|||||..||.||||||||||||||||.|:...|
 Worm   986 LDFMSYCKSFKIPHLPREKVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKASHI 1050

  Fly  1093 HVSSATKAILDKF--GTFQMEQRGDVELKGKGTVTTYWL-----------------------NST 1132
            |:|:|:..:|.|.  ..:....||||.:||||.:.|:|:                       |:.
 Worm  1051 HLSAASYTLLMKHYPNQYNTASRGDVIIKGKGVMETFWVFERNNQFMGVSSNSGYQSDKKATNNG 1115

  Fly  1133 SEGEARPP-TP 1142
            |..|:.|| ||
 Worm  1116 SSPESTPPSTP 1126

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	99/484 (20%)
		ANF_receptor	107..479	CDD:279440	88/434 (20%)
		PKc_like	616..885	CDD:304357	72/280 (26%)
		TyrKc	627..877	CDD:197581	70/258 (27%)
		HNOBA	<882..939	CDD:285003	25/58 (43%)
		CYCc	918..1109	CDD:214485	101/192 (53%)
		Guanylate_cyc	945..1131	CDD:278633	101/210 (48%)
gcy-19	NP_001348702.1	PBP1_NPR_GC_like	45..467	CDD:107347	97/475 (20%)
		PKc_like	571..841	CDD:328722	73/285 (26%)
		CYCc	876..1065	CDD:214485	101/188 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7809
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910