DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and gcy-15

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_001364713.1	Gene:	gcy-15 / 191648	WormBaseID:	WBGene00001541	Length:	1104	Species:	Caenorhabditis elegans

Alignment Length:	1180	Identity:	334/1180 - (28%)
Similarity:	526/1180 - (44%)	Gaps:	225/1180 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 VDLALDEIN-----KVF--LKPHNITLLKKKGSYPSCSGA------RAPGLAADMYFQDDVIAF- 162
            :::|::.:|     :||  |..:.:...|..|...:.:.|      .|.||..|.|.|..::..
Worm     1 MEIAINRLNADKDLEVFHDLDVNYVDTSKTAGPRAARTAALNNATVAAMGLMRDCYIQSTILNIN 65

  Fly   163 ----IGPACAFALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTSGILGRIHKWKNENTGMFKD 223
                :...|...|..|...             ||          ||.::........::...|.|
Worm    66 LKIAVSDVCEMDLSSVKGF-------------DQ----------TSVLMNSQTNSLAKSVMYFLD 107

  Fly   224 KSKYPTLTRMSYCQCRLILVFASVIRQ-----FNWNHVALLVDRSELFSWTVGKNLEYGLRQEGL 283
            |.::..:..:|  ...::..||:.:|.     ...|.:.:|||
Worm   108 KYQWKKVALVS--PSAVLTAFAARVRSDLLDALTANKIDILVD---------------------- 148

  Fly   284 LSFVKELNGNEEEVYENYLKDASMYARVVIL---SVRGVLVRKFMLAAHSLG-MTNGEWVFLDVE 344
             |.:..::...|:|.|:..|     ||:.|:   |....|:|.::.....:. |.:||:..|...
Worm   149 -SRLDPMSDITEKVKEDAEK-----ARIFIICDWSSNANLLRNYIFKLGEMNKMQSGEYFVLGYI 207

  Fly   345 IFQSEY-W-----GDK-----GWEMKDEHDAKARKAYEALLRVSLLQ----PTSPK--FQDFADN 392
            .:.:.| |     ||:     |....::::......:|....|.:|.    |..|.  ::|....
Worm   208 SYDTNYQWLEASSGDQRLVHLGASDINDYNLTENDLHEVYKNVVILSDGPPPAEPNSTWEDIKTQ 272

  Fly   393 VRENALYDY-----NYTFGEGEEVNF-FIGAFYDGVYLLGMALNETLTEGGDIRDGVNITRRMWN 451
            |.:......     |.|..|.....: .|...:|.:..|..|.|:.|..|.:|.........:.:
Worm   273 VLKKKPAKMCPPYCNTTISEKITPRWDRIKLLFDSIQYLADATNDALNIGANIYQSDIFYEHLIS 337

  Fly   452 RTFEGITGHVR-IDDNGDRDADYSILDLDPINGKFSVVAHYSGVHKVYSAVHGKKIHWPGGR--- 512
            |..:.:||... ||..|            .|.|...:..|:|      |:.|.....:|..|
Worm   338 RKVDSVTGVTEYIDGYG------------AIVGSMQIYYHFS------SSSHNSYSLFPCARLAQ 384

  Fly   513 -----------------------EEPPPDVPPCGFLGNSTDCVGNFSTIMYSVFGLLLFLGLVFL 554
                                   :..|.|.|.|||.|.:.....|.:.|:....|:.:.:||. :
Worm   385 SSLLNTVWSLTDYSEGLSIDFVNKSAPKDTPVCGFYGENCGPPANNTFIIVISVGVAVLIGLA-I 448

  Fly   555 VICLLQKQMKLSKELNNMSWRVRPDDVLIE-------------MGGMFGS-KGGLQRL------- 598
            ....|.|:.:..:.|:::.:.:..:.::::             |..:.|| ....|.|
Worm   449 AAAFLYKRYRYERRLHSLFFMIDRNQIILKKHTNLMSQQSLRSMASIHGSVVAASQTLRDSHFFI 513

  Fly   599 -DVENIS---------------------LQQFGIHSGRASIASFTSLPPQVYTTIGQFKGERVAI 641
             |..|.|                     :..||..:|.:....:..:|.   ..:|.::|..||:
Worm   514 EDYNNASSINASSIFNTGSTARAGPFGPIPGFGGVTGASEDEKWHQIPD---FGVGLYEGRTVAL 575

  Fly   642 KKVNVKKVDLTPQLLWEIKQARDVSHENTVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAI 706
            |::....|:.|.....||.:.::..:.|.:.|||..:.  .|.|.::.|...||||||:|:|:.:
Worm   576 KRIYRSDVEFTRSNRLEIAKLQESVNSNVIEFVGMVVQ--SPDVFVVYELAQRGSLKDILDNDDM 638

  Fly   707 ELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGLRTLT-----TPSD 766
            .||..||..:..||:.|:.|||:|.|..||:|:|.|||||.|:::::|.||||.|.     ...|
Worm   639 PLDDVFRSQMTKDIIAGLEYLHSSPVGCHGRLKSTNCLIDARWMVRLSSFGLRELRGEETWQQED 703

  Fly   767 FV---RDQNYYLKLLWIAPELLPLTTIPGCCPA--TQRGDVYSFGIILEEIVNRGGPYQEARQQM 826
            .|   :||      ||.:||||..:|....|..  .|:.||||..|:|.|:..|.||:.:  :.|
Worm   704 DVQEGKDQ------LWTSPELLRWSTGLSQCGVLLVQKSDVYSLAIVLYELFGRLGPWGD--EPM 760

  Fly   827 DVHTILHKVRQ-----CNGFRP-LIRERECPPDLLELMEKCWADNQEERPTFSTIRSNIRTIMKG 885
            :...|:..|::     ...||| :...:|.|..:.|.:...|.::...||:...|:..::.:..|
Worm   761 EPREIVSLVKREALAGKKPFRPDMAVLKESPRIVQETVVAAWTEDPLNRPSLHQIKRKLKPLTIG 825

  Fly   886 FCENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEF 950
            ....:||::::.:|:|.:.||..:.|:..:|..||.::|.||..:||..||..|..|..|..|.|
Worm   826 LKRTIMDNMVSMIEKYTDKLEKDIAERNEELEAEKAKSEALLKMMLPEVVADSLKLGSNVSAESF 890

  Fly   951 SSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPN 1015
            .:.|::|||..||.|:.|.|.|:|:|.||||||:.|||||..:||||||||.|||:|.||||.||
Worm   891 ENCTVFFSDCPGFVEMSATSKPIDIVQFLNDLYTVFDRIIDQFDVYKVETIADAYMVASGLPVPN 955

  Fly  1016 GDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTA 1080
            |:.||.|||.:.|.:|:||.||.:||.|..|:::||||:||...|||||.|||.|||||||||||
Worm   956 GNHHAGEIASLGLALLKAVESFKIRHLPNEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTA 1020

  Fly  1081 SRMESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVELKGKGTVTTYWLNSTSEGEARPPTPQIL 1145
            |||||.|.|.:|:.|...|.|||:.|.:::|:||.||:||||...||::    .||......:.:
Worm  1021 SRMESNGIPLRINCSGTAKEILDQLGGYEIEERGIVEMKGKGKQMTYFV----RGENSDMRRERI 1081

  Fly  1146 TTDEVPFPLL 1155
            ..:.|.|..|
Worm  1082 IRERVKFASL 1091

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	80/434 (18%)
		ANF_receptor	107..479	CDD:279440	76/417 (18%)
		PKc_like	616..885	CDD:304357	89/284 (31%)
		TyrKc	627..877	CDD:197581	88/265 (33%)
		HNOBA	<882..939	CDD:285003	18/56 (32%)
		CYCc	918..1109	CDD:214485	110/190 (58%)
		Guanylate_cyc	945..1131	CDD:278633	110/185 (59%)
gcy-15	NP_001364713.1	Periplasmic_Binding_Protein_type1	2..363	CDD:415822	78/425 (18%)
		PK_GC	553..822	CDD:270894	89/281 (32%)
		HNOBA	<831..879	CDD:400168	17/47 (36%)
		Guanylate_cyc	885..1071	CDD:306677	110/189 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920