Protein Alignment CG3216 and gcy-14

DIOPT Version :10

• Sequence 1: NP_726013.2
• Gene: CG3216 / 37376
• FlyBaseID: FBgn0034568
• Length: 1161
• Species: Drosophila melanogaster
• Sequence 2: NP_506660.2
• Gene: gcy-14 / 191647
• WormBaseID: WBGene00001540
• Length: 1111
• Species: Caenorhabditis elegans
• Alignment Length: 1155
• Identity: 353/1155 - (30%)
• Similarity: 555/1155 - (48%)
• Gaps: 191/1155 - (16%)

  Fly    83 GSTMRVYNVGVLMASHLDSPFDLERCG-----PAVDLALDEINKVFLKPH---NITLLKKKGSYP 139
            |..::...||:|.:.  |:...:...|     .||.:|.|.|....|...   |.|:     .:.
 Worm    14 GQFLQTVKVGLLFSK--DTASVMRAVGYRTSAAAVLVARDRIRAEHLLDQYDFNFTV-----KFD 71

  Fly   140 SCSGARAPGLAADMYFQDDVIAFIGPACAFALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTS 204
            .|:...|.|...::...|:|...|||.|..|...||.||||:|.|:.          :..|| |:
 Worm    72 ECTEGLAGGKTVELINHDNVDVIIGPTCNRAGIAVASLAAYYNVPVF----------QWGLT-TA 125

  Fly   205 GILGRIHKWKNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNWNHVALLV--DRSELFS 267
            ..:|.:              |:|||...:|.....:.|....|:|:|.|:....:.  |..|...
 Worm   126 ADIGNV--------------SRYPTTVTLSLDTHSMALGVREVLRRFEWDEFVFIYSNDGDEEKC 176

  Fly   268 WTVGKNLE-YGLRQEGL-LSFVKELNGNEEEVYENYLKDASMYARVVI---LSVRGVLVRKFMLA 327
            .::..:|| .|:....: |:::.::.....:..:..|.:.|...|::|   .:.|| ..:.|:.:
 Worm   177 ASMKDDLEKMGIENSDVTLAYMVQIQTVTLDALQKALTEVSKRGRIIIACFANGRG-FKKAFVAS 240

  Fly   328 AHSLGMTNGEWVFLDVEIFQSEYWGDK-------GWEMKDEH------DAKARKAYEALLRV--S 377
            ....||:..|::::..|.....::.|:       .|:..|.:      ..:.|.||..:|.:  :
 Worm   241 TVLAGMSTDEYMYMFAEPQSRGFYVDEINGGEHYSWDDTDGNFVTGLTPEQIRDAYGKVLYICDN 305

  Fly   378 LLQPT--SPKFQDFADNV--------------RENALYDYNYTFGEGEEVNFFIGAFYDGVYLLG 426
            :..||  :|:|.:|:..:              ..|:.|....|:.         |..:|..|..|
 Worm   306 MGLPTTITPEFANFSSQLISRMTEQPFNCVQDCSNSTYKVPATYA---------GQLFDAFYAYG 361

  Fly   427 MALNETLTEG---GDIRDGVNITRRMWNRTFEGI-TGHVRIDDNGDRDADYSILDLDPINGKFSV 487
            :|||.:||:.   .::::|..:...: ..:|:|: .|.|.:||.|.|.....:..|:      :.
 Worm   362 VALNRSLTQDPTRANLKNGSFVLSDI-GMSFQGVGGGTVTLDDTGTRIVQVYMFALN------TS 419

  Fly   488 VAHYSGVHKVYSAVHGKKIHW-PGGREEP------PPDVPPCGFLGNSTDCVGNF--STIMYSVF 543
            :..|.....|   ::|.::.: |..:.|.      |...|.|||.|  .:|..:|  ..::|::.
 Worm   420 LLPYLAASLV---INGSEVEYTPFYKSEADLWSVRPLARPICGFSG--LECPPDFVKEYLVYTII 479

  Fly   544 GLLLFLGLVFLVIC---LLQKQMKLSK-ELNNMSWRVRPDDVLIEMGGMFGSKGGLQRLDVENIS 604
            ..::.: |..|..|   |...|||..: |..::.|:                        |..|.
 Worm   480 AAVIVV-LALLAGCAGLLYTMQMKRKEMERQDLLWQ------------------------VPFIE 519

  Fly   605 LQQFGIHS-GRASIASFTSLPPQVYTTIGQFKGERV-------------AIKKVNVKKVDLTPQL 655
            |||....| ..||:.||.|.|........:.:.|.:             |:|...:.:.|...:.
 Worm   520 LQQVQSKSKAEASMHSFASGPSTSTKITVESRSETINFIFYYYQQDILAAMKHDLILQFDAEQKA 584

  Fly   656 LWEIKQARDVSHENTVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDI 720
              |.:|.|:..::|..:|:|.|:|  .|.:..|..:||||||.||:...::::|..|..|||.||
 Worm   585 --EFRQMRNFDNDNLNKFIGLCLD--GPQLFSLWRFCSRGSLSDVISKSSMQMDSFFMFSLIRDI 645

  Fly   721 VKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGLRTLTTPSDFVRDQNYYLKLLWIAPELL 785
            ..|:.::|||.:..||.|.|..||||.|:.:|||.:||:::.|..:..::.     |||..||.|
 Worm   646 SNGLLFIHNSFLKCHGHLTSRCCLIDDRWQIKISGYGLKSVRTFENPKKED-----LLWTPPENL 705

  Fly   786 PLTT---IPGCCPATQRGDVYSFGIILEEIVNRGGPY--QEARQQMDVHTILHKVRQ--CNGFRP 843
            ....   :|       .||:||||||..||:.|...:  :..:::.||  |:::|::  .|..||
 Worm   706 RNENEERLP-------EGDIYSFGIICSEILTRSSAFDLENRKEKPDV--IIYQVKKGGHNPMRP 761

  Fly   844 LI---RERECPPDLLELMEKCWADNQEERPTFSTIRSNIRTIMKGFCENLMDDLLNRMEQYANNL 905
            .:   ...|..|.||.|:..||.:...|||:...:|.::..:..|...||||.:.|.:|.||:.|
 Worm   762 SLDTGETVEINPALLHLIRDCWTERPSERPSIEQVRGHLNGMRDGRKSNLMDHVFNMLETYASTL 826

  Fly   906 ESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARS 970
            |..|.::|::|..||::::.|||::||:.||.:|..|..||||.|..|||:|||:|.||.|..:.
 Worm   827 EEEVSDRTKELVEEKKKSDVLLYRMLPKMVADKLKLGQTVEPETFEQVTIFFSDVVQFTTLAGKC 891

  Fly   971 SPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVS 1035
            :|:.||..|||||:.||.||...||||||||||.||.|||||..||::|.|.||.|:|..|.::.
 Worm   892 TPLQVVTLLNDLYTIFDGIIEQNDVYKVETIGDGYLCVSGLPHRNGNEHIRHIARMSLGFLSSLE 956

  Fly  1036 SFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSS-ATK 1099
            .|.::|.|..:|.:|||::.|||.|||||..||.||||||.|||||||||.|:||||||:: |.:
 Worm   957 FFRVQHLPSERINLRIGINCGSVVAGVVGLTMPRYCLFGDAVNTASRMESNGKPGKIHVTAEANQ 1021

  Fly  1100 AILDKFGTFQMEQRGDVELKGKGTVTTYWL------NSTSEGEARPPTPQ 1143
            .:....|.|:.|.||:|.:||||.:.||||      .|.|....|..||:
 Worm  1022 MLTQVVGGFRTESRGEVIIKGKGVMETYWLLGEQSRISVSAQAPREKTPE 1071

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_GC-like	90..501	CDD:380575	98/460 (21%)
		Protein Kinases, catalytic domain	616..885	CDD:473864	89/291 (31%)
		HNOBA	<891..939	CDD:462234	20/47 (43%)
		CYCc	918..1109	CDD:214485	105/191 (55%)
gcy-14	NP_506660.2	PBP1_NPR_GC-like	21..419	CDD:380575	96/446 (22%)
		Protein Kinases, catalytic domain	535..800	CDD:473864	88/282 (31%)
		HNOBA	<816..860	CDD:462234	18/43 (42%)
		CYCc	839..1031	CDD:214485	105/191 (55%)