DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and gcy-9

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_509897.3	Gene:	gcy-9 / 191645	WormBaseID:	WBGene00001536	Length:	1081	Species:	Caenorhabditis elegans

Alignment Length:	1145	Identity:	320/1145 - (27%)
Similarity:	525/1145 - (45%)	Gaps:	217/1145 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 GVLMASHL--------DSPFDLERCGPAVDLALDEINKVFLKPHNITLLKKKGSYPSCSGARAPG 148
            |::...||        ..|..|:.|.       |::....:.|.|.||  ...:..||:......
Worm    40 GIVRIGHLHPTNPIIAHEPDVLKMCA-------DDLKMRNILPQNYTL--TVFTMESCNKYSGVE 95

  Fly   149 LAADMYFQDDVIAFIGPACAFALEPVARLAAYWNKPIITGM-GDQPPSSEGELTVTSGILGRIHK 212
            .||.:::..:...:.||.|...:..:.|||..||.|||..| ||...|
Worm    96 HAAFLHYLKNASVYFGPGCNNEMLVIGRLAPRWNVPIIAHMSGDDALS----------------- 143

  Fly   213 WKNENTGMFKDKSKYPTLTRMSYCQC-RLILVFASVIRQFNWNHVALL-----VDRSELFSWTVG 271
                      |:.::|||..::.... .:.....:.:...||:.:.::     .:|..::|
Worm   144 ----------DRVQFPTLGSVALTSASEMAKATVTYLNLNNWDQIGIVRPSVGYERLSVYS---- 194

  Fly   272 KNLEYGLRQE----GLLSFVKELNGNEEEVYENYLKDASMYARVVILSVRGV---LVRKFMLAAH 329
              |::.:::.    .::..::..:..||.:....|......||::::.: |:   .|..||||.|
Worm   195 --LQHQIKKRDINLNVILDIEPFSSPEEIISTGKLTTLKSMARIIVVEL-GMDIHSVTNFMLAIH 256

  Fly   330 SLGMTNGEWVFLDVEI-FQSEYWGDKGWEMKDEHDAKARKAYEALLRVSLLQPTSPKFQDF---- 389
            ...:.|.|:||:...: .|::::   .||..:....:.:.|:|..:.::........|.||
Worm   257 RSEIKNEEFVFVIPWLAHQNDHY---PWEAANVDKQEVKLAFENTIIITAHGYDKKFFDDFQMKF 318

  Fly   390 --ADNVRENALYDYNYTFGEGEEVNFFIGAFYDGVYLLGMALNETLTEGGDIR---DGVNITRRM 449
              ...|..|.....:|.            :.||.::|.|:||.:...:||...   :|..|..||
Worm   319 SAVTGVLANHYATLSYM------------SLYDALFLYGLALRDAFEDGGGYNVHMNGSLIWSRM 371

  Fly   450 WNRTFEGITGHVRIDDNGDRDADYSILDLDPINGKFSVVAHYS----------------GVHKVY 498
            .||.|.|:||.|.:::...|...|:  ....|||...:|....                ..|..:
Worm   372 TNRQFIGMTGQVLMNNKAIRVPSYA--TYHAINGTLKIVVELEAKNNDRGQCEKNEEMCSEHVAH 434

  Fly   499 SAVHGKKIHWPGGREEPPPDVPPCGFLGNSTDCVGNFSTIMYSVFGLLLFLGLVFLVICLLQKQM 563
            ..:   :.:||....:.||.||.|||.|...|....|  |..|:...:|.:|.:...|.|.||:
Worm   435 ETI---QYYWPSDSGKLPPAVPKCGFTGAECDYRPYF--IGASLLAFILTVGPLSYFIYLKQKE- 493

  Fly   564 KLSKELNNMSWRVRPDDV------------LIEMGGMFGSKGGLQRLDVENISLQQFGIHSGRAS 616
               :.|.:|:||:..:.:            |.......||..|       :::.:|.|:.:.:.:
Worm   494 ---RLLYDMTWRIPRESIKMLEGKSKSEHSLASKSQSSGSFSG-------SMNSKQNGLIAAKQA 548

  Fly   617 IASFTSLPPQVYTTIGQFKGERVAIKKV-NVKKVDLTPQLLWEIKQARDVSHENTVRFVGACIDL 680
            :::                |.::|||:. .|:.:......|..:|:.:...::|..:|.|...:
Worm   549 VSN----------------GVKLAIKRYQQVRNITFPKSELRLLKELKICENDNLNKFYGISFN- 596

  Fly   681 PRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLI 745
            .:...:::...||||||:|:|.|:.::|..||::|...|:|||:|:||.|.:..||.|...|||:
Worm   597 QQNEFIVMWVLCSRGSLEDILFNDELKLGRNFQVSFAKDVVKGLNFLHTSPLLHHGMLCLQNCLV 661

  Fly   746 DGRFVLKISDFGLRT--------------LTTPS-----------DFVRDQNYYLKLLWIAPELL 785
            |..:.:|:::|....              :.|.|           ||.|.     |.|..|||::
Worm   662 DSNWTVKLTNFATEAVIFEKLDHNELRPFINTDSESADDVSDPTKDFARK-----KYLQQAPEII 721

  Fly   786 ----PLTTIPGCCPATQRGDVYSFGIILEEIVNRGGPYQEARQQMDVHTILHKVRQCNGFRPLIR 846
                ...|||   ..:|..|:|:.|::|.:|:.|..|:.|  :...::.::..:...|....|||
Worm   722 REIVTTKTIP---EGSQSADIYALGMVLYQILFRVEPFHE--RNKSINKLMETLAMANDDDQLIR 781

  Fly   847 ERECPP------------DLLELMEKCWADNQEERPTFSTIR----SNIRTIMKGFCENLMDDLL 895
                |.            .||..:|.||.:..|.||....:|    :|:::..||   :|:|.::
Worm   782 ----PTFPSSNTGEGYNLQLLSCIEACWLEIPEMRPPIKKVRTMVNANLKSTGKG---SLVDQMM 839

  Fly   896 NRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDI 960
            ..||:|..|||::|.::|..|...:::.:.||..:||:.:|:.|..|..|.|:.:|..|:.||||
Worm   840 KMMEEYTANLENMVRDRTALLEEAQKQADRLLNSMLPKSIAEDLKIGKPVLPQLYSCATVLFSDI 904

  Fly   961 VGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIAL 1025
            .|||.:.:.|:|:.||.||||::|.||.||..:|.||||||||||::|||:|..||:.||:.||.
Worm   905 RGFTRISSTSTPLQVVTFLNDMFSGFDAIIAKHDAYKVETIGDAYMIVSGVPTENGNSHAQNIAD 969

  Fly  1026 MALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPG 1090
            :||.:...:.:|.|.|:||..:.:|||.|||.|.|||||...|.||||||||||||||||||...
Worm   970 VALKMRAFICNFKLAHRPEELMMVRIGFHSGPVAAGVVGLAAPRYCLFGDTVNTASRMESTGVAN 1034

  Fly  1091 KIHVSSATKAILD-KFGTFQMEQRGDVELKGKGTVTTYWL 1129
            ||.:|.....:|. .|..|||.:||.:|:||||...||:|
Worm  1035 KIQISEGAYNLLHCFFPQFQMVERGKIEVKGKGECLTYYL 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	91/451 (20%)
		ANF_receptor	107..479	CDD:279440	82/395 (21%)
		PKc_like	616..885	CDD:304357	77/314 (25%)
		TyrKc	627..877	CDD:197581	76/295 (26%)
		HNOBA	<882..939	CDD:285003	18/56 (32%)
		CYCc	918..1109	CDD:214485	95/191 (50%)
		Guanylate_cyc	945..1131	CDD:278633	101/186 (54%)
gcy-9	NP_509897.3	Periplasmic_Binding_Protein_Type_1	66..416	CDD:299141	85/402 (21%)
		ANF_receptor	69..404	CDD:279440	82/387 (21%)
		PKc_like	550..820	CDD:304357	75/300 (25%)
		HNOBA	<837..883	CDD:285003	14/45 (31%)
		CYCc	862..1054	CDD:214485	95/191 (50%)
		Guanylate_cyc	889..1076	CDD:278633	101/186 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920