DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and gcy-5

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_496219.1	Gene:	gcy-5 / 191643	WormBaseID:	WBGene00001532	Length:	1122	Species:	Caenorhabditis elegans

Alignment Length:	1146	Identity:	353/1146 - (30%)
Similarity:	553/1146 - (48%)	Gaps:	162/1146 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 STMRVYNVGVLMASHLDS-PFDLERCGPAVDLALDEI-NKVFLKPHNITLLKKKGSYPSCSGARA 146
            |:.|...||:..|....| ......||..:.:|:..: :|.||...::....:   |..|.  ||
Worm    24 SSRRTLRVGIAAAQDTQSGSIGWASCGGTLPIAVQYLKSKGFLTDFDVEYYME---YTECD--RA 83

  Fly   147 PGLAADMYFQDD--VIAFIGPACAFALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTSGILGR 209
            ....|.|.|..:  |...:||:|..||..:..|:|.:.|.                     :||
Worm    84 SVAKAGMKFMKEMNVDVVVGPSCGDALAIMGTLSAIYKKL---------------------VLG- 126

  Fly   210 IHKWKNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNWNHVALLVDRSEL-FSWTVGKN 273
               |...:.....|.:::|.:..:......|.|..:.::..|.::.||||..:.:. :..:|..:
Worm   127 ---WGFVSDTQLADTNRFPYVASVQPTAQTLGLATSRILEMFQFDRVALLYYKDDQDYCKSVMDD 188

  Fly   274 LEYGLRQEGL----LSFVKELNGNEEEVYENYLKDASMYARVVIL-SVRGVLVRKFMLAAHSLGM 333
            :|..|....|    :.:..||..:.|.:..:.|:.....||:|:| ::.|...|.::::.....|
Worm   189 VEATLSDPDLYPVRIVWKGELQSDNEALTRSTLQAVKSRARIVLLCAISGPEKRNYLISIAQQNM 253

  Fly   334 TNGEWVFLDVEIFQSEY-----WGDKG--------WE----MKDEHDAKARKAYEALLRVSL--- 378
            |..|:|.:.:.:....|     .|.|.        ||    ..|.::..||:|.|.:|.:.:
Worm   254 TTNEYVHILLTMRSIGYGVQTSLGKKTFANGLTPLWESFTVAPDGNETNARRAAEKMLVIDVNSD 318

  Fly   379 ------LQPTSPKFQDFADNVRENALYDYNYTFGEGEEVN---FFIGAF----YDGVYLLGMALN 430
                  ||..:   ::.||.||...:     .....|.:|   ..:|::    :|..||.|||::
Worm   319 VQDAEFLQYLT---KNIADAVRNPPM-----KCNTSECINASSTSMGSYARHLFDVFYLYGMAVS 375

  Fly   431 ETLTEGGDIRDGVNITRRMWNRTFEGITGHVRIDDNGDRDADYSILDLDPINGKFSVVA------ 489
            :..:....:...:|:.......:|:|:||.|:|..|..|...|.:..||.   |:..||
Worm   376 KLNSTDPTVYGNLNLLMPQMVTSFDGMTGRVQIGQNLYRVPTYQLYGLDE---KYEQVALVNMTF 437

  Fly   490 --HYSGVHKVYSAVHGKKI--HWPGGREEPPPDVPPCGFLGNSTDCVGNFSTIMYSVFGLLLFLG 550
              ..|.:.:.||. .|:.:  .|.|.|   |.|.|.|||.|..  |...|    :..:|:|:|:.
Worm   438 YNSSSQLSRGYSD-EGRSVWHFWDGTR---PLDTPICGFSGRY--CPVQF----WDQYGVLIFVA 492

  Fly   551 ---LVFLVICLLQ------KQMKLSKELNNMSWRVRPDDVLIEMGGMFGSKGGLQRLDVENISLQ 606
               |:||:..:|.      :..:..:|..|..|:: |...|| |......|...:|      |||
Worm   493 SIVLIFLICIMLMCFGFMIRGRRAEQERLNSEWQI-PSIQLI-MPQKEKRKPNSRR------SLQ 549

  Fly   607 QFGIHSGRASIASFTSLP-----PQVYTTIGQFKGERVAIKKVNVKKVDLTPQLLWEIKQARDVS 666
                 ||.::|...:.:.     .:.| |:..|:.:.|...|.:  .:.:..:...:..:.|.:.
Worm   550 -----SGPSTITGESKMTIDGGFHENY-TVQMFEKDLVLTTKHH--SMQMNKEEKEKFVKLRKLE 606

  Fly   667 HENTVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSD 731
            |:|..:|:|..||  .|..:.:.:.||||||:|::......:|..|...:|.||.:|||:||.|.
Worm   607 HDNLNKFIGLSID--GPQFVAVWKMCSRGSLQDIIARGNFSMDGFFMFCIITDIAEGMNFLHKSF 669

  Fly   732 VAAHGKLRSCNCLIDGRFVLKISDFGLRTLT---TPSDFVRDQNYYLKLLWIAPELL-PLTTIPG 792
            :..||.|||..||::..:.:|::||||..|.   |||.        .:|||.|||:| ...||..
Worm   670 LHLHGNLRSATCLVNDSWQVKLTDFGLGALLEEHTPSK--------KRLLWAAPEVLRGSLTIHQ 726

  Fly   793 CCPATQRGDVYSFGIILEEIVNRGGPYQEARQQMDVHTILHKVRQCNG--FRP-LIRERECPPDL 854
            ..|:   .|||||.||..||:.:...:..:.::.....||:.|::...  .|| ||.:.|..|.|
Worm   727 MDPS---ADVYSFAIIASEILTKREAWDISNRKEGADEILYMVKKGGNRTIRPELILDAEVSPRL 788

  Fly   855 LELMEKCWADNQEERPTFSTIRSNIRTIMKGFCENLMDDLLNRMEQYANNLESLVEEKTRQLSLE 919
            ..|::.||::..|:||....|...:..:......||||.:.|.:|:|.:.||..:||:|::|:||
Worm   789 TTLVKDCWSEQPEDRPKAEQICKLLSEMTPRGNTNLMDHVFNMLEEYTSTLEVDIEERTKELTLE 853

  Fly   920 KQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYS 984
            |::.:.||.::||:.||::|.||..||||.|.:||:.|||:|.||:|.|:.||..|||.||||||
Worm   854 KKKADILLSRMLPKQVAERLKAGQTVEPEGFDTVTVLFSDVVKFTQLAAKCSPFQVVNLLNDLYS 918

  Fly   985 TFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQI 1049
            .||.||..:.|||||:|||.||.|||||..||..|.::|..|:|..:....||.:.|.|..|:::
Worm   919 NFDTIIEEHGVYKVESIGDGYLCVSGLPTKNGYAHIKQIVDMSLKFMDYCKSFKVPHLPREKVEL 983

  Fly  1050 RIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFGTFQME--Q 1112
            |||::||...|||||..||.||||||||||||||||.|:|..||:|.|..::|......|.|  .
Worm   984 RIGINSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSMIHMSEAAHSLLTDHYPHQYETSS 1048

  Fly  1113 RGDVELKGKGTVTTYWLNSTSEGEARP----PTPQILTTDE 1149
            ||:|.:||||.:.|:|:...::.:.:.    .||.|  |||
Worm  1049 RGEVIIKGKGVMETFWVLGKTDSDTKSLSTRTTPPI--TDE 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	98/456 (21%)
		ANF_receptor	107..479	CDD:279440	88/413 (21%)
		PKc_like	616..885	CDD:304357	84/280 (30%)
		TyrKc	627..877	CDD:197581	83/256 (32%)
		HNOBA	<882..939	CDD:285003	22/56 (39%)
		CYCc	918..1109	CDD:214485	103/190 (54%)
		Guanylate_cyc	945..1131	CDD:278633	102/187 (55%)
gcy-5	NP_496219.1	PBP1_NPR_GC_like	30..440	CDD:107347	97/450 (22%)
		ANF_receptor	49..426	CDD:279440	90/417 (22%)
		PK_GC	546..816	CDD:270894	90/296 (30%)
		HNOBA	<830..873	CDD:285003	18/42 (43%)
		CYCc	852..1042	CDD:214485	103/189 (54%)
		Guanylate_cyc	879..1067	CDD:278633	102/187 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I5035
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910