DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and gcy-3

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_496037.1	Gene:	gcy-3 / 191641	WormBaseID:	WBGene00001530	Length:	1140	Species:	Caenorhabditis elegans

Alignment Length:	1169	Identity:	348/1169 - (29%)
Similarity:	545/1169 - (46%)	Gaps:	194/1169 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 GSTMRVYNVGVLMASHLDS-PFDLERCGPAVDLALDEINKVFLKPHNITLLKKKG---------- 136
            |:|.....||:..|....| ......||.||.||::.             ||:.|
Worm    29 GTTRPKLKVGIAAAQKTQSASIGWNVCGGAVPLAIER-------------LKQAGYVTNFDFEYY 80

  Fly   137 -SYPSCSGARAPGLAADMYFQDDVIAFIGPACAFALEPVARLAAYWNKPIITGMGDQPPSSEGEL 200
             .|..|..|.......:.....:|...|||.|:.|:..:|.||..:.||:: |.|.   .|:.:|
Worm    81 VEYTECDLASTVRTGINFLKNLEVDVIIGPPCSEAIRTMATLATLYKKPVL-GWGF---VSQADL 141

  Fly   201 TVTSGILGRIHKWKNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNWNHVALLVDRSEL 265
            :                     |.:::|.|..:......|....:.::..:.|:.||||..:||:
Worm   142 S---------------------DMTRFPYLITVLPTSQTLGYAASKLLELYKWDKVALLYYKSEV 185

  Fly   266 ---------FSWTVGKNLEYGLRQEGLLSFVKELNGNEEEVYENYLKDASMYARVVILSVR-GVL 320
                     ...|......|.::    :....|::.::.......:......||:::...: |..
Worm   186 NHCGGVMNDVETTFNDPSTYSIQ----IVLKAEIDASDNVTTNAVISSVKTRARIILWCAQLGSE 246

  Fly   321 VRKFMLAAHSLGMTNGEWVFLDVEI----FQSEYWGDKG----------WE----MKDEHDAKAR 367
            .|.:|:....||:...|:|.:.:.:    |..:.:..|.          ||    :.|..:..|:
Worm   247 KRDYMIKISQLGLDTDEYVHVLISMRSIGFGVQTFVGKTTFKLSGLTPVWESFSNVTDGLENVAK 311

  Fly   368 KAYEALLRVSLLQPTSPKFQDFADNVRENAL------------YDYNYTFGEGEEVNFFIGAF-- 418
            :....:|.:.|....|.|  .:.|.::.|.|            .|...:...|      :||:
Worm   312 RGATNVLVIDLNSEVSDK--AYLDYMQRNILNVVKLPPLNCSTVDCVSSTATG------MGAYAR 368

  Fly   419 --YDGVYLLGMALNETLTEGGDIRDGVNITRRMWNRTFEGITGHVRIDDNGDRDADYSILDLDP- 480
              :|.|||.|:||....:....:.|.::.....:..:|.|:||.|.|:.|..|...|.:..||.
Worm   369 HLFDVVYLYGIALTRVNSTDSAVYDDMSKLIPQFVTSFNGMTGLVAINQNLSRMPLYQLYGLDEQ 433

  Fly   481 ------INGKFSVVAHYSGVHKVYSAVHGKKIHWPGGREEPPPDVPPCGFLGNSTDCVGNFSTIM 539
                  :|..|:.....:.:...||.......|:.||..  |...|.|||||||  |...|
Worm   434 YEQTSLMNLSFADGTTVATISLAYSNESSAVWHFWGGIR--PLATPICGFLGNS--CPLPF---- 490

  Fly   540 YSVFGLLLFLGL-VFLV------ICLL-------QKQMKLSKELNNMSWRVRPDDVLIEMGGMFG 590
            :..:|:|:|:|. |||:      ||.|       ::|.:::.|     |:: |...|.|:...
Worm   491 WEQYGILIFVGAGVFLIMITTNLICFLFMIKNRREEQARINSE-----WQI-PFVKLRELERK-- 547

  Fly   591 SKGGLQRLDVENISLQQF-GIHSGRASIASFTSLPPQVYTTIGQFKGERVAIKK---VNVKKVDL 651
            |||..:|      |||.. ...:|.:.:::.:......  .:..|:.:.|...|   :|:.|.|:
Worm   548 SKGTSKR------SLQSAPSTITGESKVSTGSEFCENY--EVKMFEKDMVLTMKFQYMNLNKADM 604

  Fly   652 TPQLLWEIKQARDVSHENTVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSL 716
            .     :..:.|.:.|||..:|:|..||..:  .:.:|:.||||||.|:|......:|:.|...:
Worm   605 D-----KFVKLRKLDHENLNKFIGLSIDSSQ--FISVTKLCSRGSLLDILYKGNFSMDFFFMYCI 662

  Fly   717 IHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGLRTL---TTPSDFVRDQNYYLKLL 778
            |.|:.:||:|||.|.:..||.|||..||::..:.:|:::||...|   .||:.        .:||
Worm   663 IKDVAEGMSYLHKSFLRLHGNLRSATCLVNDSWQVKLAEFGFDQLLEEITPTK--------RRLL 719

  Fly   779 WIAPELLPLTTIPGCCPATQ---RGDVYSFGIILEEIVNRGGPYQEARQQMDVHTILHKVRQCNG 840
            |.|||:|     .|....:|   ..||:||.||..||:.|...:....::.....|:::|::...
Worm   720 WAAPEVL-----RGSLTVSQMDPSADVFSFAIIASEILTRKEAWDLKERKEGYDEIIYRVKKGGS 779

  Fly   841 F--RP-LIRE-RECPPDLLELMEKCWADNQEERPTFSTIRSNIRTIMKGFCENLMDDLLNRMEQY 901
            |  || :|.: .:..|.|:.|::.|||:..|:|||...|...:|.:|.....||||.:.|.:|:|
Worm   780 FPIRPDIITDVPDVNPTLIALVKDCWAEAPEDRPTAENICEQLRDLMPKTKSNLMDHVFNMLEEY 844

  Fly   902 ANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTEL 966
            .:.||..|||:|::|:|||::.:.||.::||:.||::|.||..||||.|.|||::|||:|.||.|
Worm   845 TSTLEVEVEERTKELTLEKKKADLLLSRMLPKQVAERLKAGQTVEPEGFDSVTVFFSDVVKFTIL 909

  Fly   967 CARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDIL 1031
            .::.:|..|||.||||||.||.||..:.|||||:|||.||.|||||..||..|.::|..|:|..:
Worm   910 ASKCTPFQVVNLLNDLYSNFDTIIEEHGVYKVESIGDGYLCVSGLPTRNGFNHIKQIVDMSLKFM 974

  Fly  1032 RAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSS 1096
            ....:|.:.|.|..::::|||::||...|||||..||.||||||||||||||||.|:|..||::|
Worm   975 DYCKNFKIPHLPRERVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSLIHLTS 1039

  Fly  1097 ATKAILDKFGTFQME--QRGDVELKGKGTVTTYWLNSTS-------EGEARPPTPQILTTDEVP 1151
            ....:|.|....|.|  .||:|.:||||.:.|:|:...|       ...:.||..|...|...|
Worm  1040 DAHLLLMKHFPHQYETNSRGEVIIKGKGVMETFWVLGRSGDIEPSISNRSTPPVTQERFTVRAP 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	92/468 (20%)
		ANF_receptor	107..479	CDD:279440	84/426 (20%)
		PKc_like	616..885	CDD:304357	83/281 (30%)
		TyrKc	627..877	CDD:197581	81/262 (31%)
		HNOBA	<882..939	CDD:285003	24/56 (43%)
		CYCc	918..1109	CDD:214485	100/190 (53%)
		Guanylate_cyc	945..1131	CDD:278633	99/187 (53%)
gcy-3	NP_496037.1	PBP1_NPR_GC_like	36..453	CDD:107347	92/466 (20%)
		ANF_receptor	54..433	CDD:279440	86/428 (20%)
		PKc_like	554..823	CDD:304357	86/296 (29%)
		HNOBA	<839..882	CDD:285003	19/42 (45%)
		CYCc	861..1051	CDD:214485	100/189 (53%)
		Guanylate_cyc	888..1076	CDD:278633	99/187 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I5035
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910