Protein Alignment CG3216 and gcy-1

DIOPT Version :10

• Sequence 1: NP_726013.2
• Gene: CG3216 / 37376
• FlyBaseID: FBgn0034568
• Length: 1161
• Species: Drosophila melanogaster
• Sequence 2: NP_496039.1
• Gene: gcy-1 / 191639
• WormBaseID: WBGene00001528
• Length: 1137
• Species: Caenorhabditis elegans
• Alignment Length: 1166
• Identity: 349/1166 - (29%)
• Similarity: 547/1166 - (46%)
• Gaps: 185/1166 - (15%)

  Fly    85 TMRVYNVGVLMASHLD-SPFDLERCGPAVDLALDEINKV-FLKPHNITLLKKKGSYPSC---SGA 144
            |.|...:|:..|..:. |......||.||.||::.:.:: |:|..:...:.   .|..|   |..
 Worm    30 TKRTIKIGIAAAQRIQTSSIGWSVCGGAVPLAIERLKEMGFVKDFDFEYIV---DYTECDLGSVV 91

  Fly   145 RAPGLAADMYFQDDVIAFIGPACAFALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTSGILGR 209
            || |:......:.|||  |||.||.||..::.||..:.||:: |.|.   .|:.:|:
 Worm    92 RA-GMEFIKTHKVDVI--IGPPCAQALRLMSFLAENYKKPVL-GWGF---VSDTDLS-------- 141

  Fly   210 IHKWKNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNWNHVALLV-------------D 261
                         |..::|.||.:......|....:.::..|:||.||||.             |
 Worm   142 -------------DVIRFPHLTTVIPNSLMLGYAASKMLTTFHWNRVALLYYFSDVKYCSGVMND 193

  Fly   262 RSELFSWTVGKNLEYGLRQEGLLSFVKELNGNEEEVYENYLKDASMYARVVILSVR-GVLVRKFM 325
            ....|:.....|:...::.|..|        |:.|..:|..:.....||:::...: .|..|.::
 Worm   194 IEATFNDPSTPNVNIVIKAEIYL--------NDNETTDNVFQTVKSRARIILWCTQTSVEKRDYL 250

  Fly   326 LAAHSLGMTNGEWVFLDVEIFQSEY----------WGDKG----WEMKDE-HDAKARKAYEALLR 375
            :...:..|...|:|.:.:.:....:          :...|    ||...| .|...:.|.:|..|
 Worm   251 IKIATHDMIGDEYVHIMLSMRNVAFGTQTSLGKPTFSQSGLTPIWESFTEGTDGFEKMAKQAATR 315

  Fly   376 VSLLQPTSPKFQDFADNVRENALYDY--------------NYTFGEGEEVNFFI-GAF----YDG 421
            :.:|        |....|.:....:|              |.:..|....|..| |.:    :|.
 Worm   316 MFVL--------DVNSEVADKKYLEYMQKNIIKAVQSPPMNCSTVECMTANTTIMGGYARHLFDV 372

  Fly   422 VYLLGMALNETLTEGGDIRDGVNITRRMWNRTFEGITGHVRIDDNGDRDADYSILDLDPINGKFS 486
            |||.|:||..|.:....:...|::....:..:|:|:||||.|..|..|   ..|..|..:|..:.
 Worm   373 VYLYGIALTHTNSTDPAVYGDVDVLVHQFVTSFQGMTGHVVISPNLTR---MPIFQLYGLNSDYD 434

  Fly   487 VVA--HYSGVHKV-------YSAVHGKKIHWPGGREEPPPDVPPCGFLGNSTDCVGNF----STI 538
            .||  .::..:.|       :....|..: |.......|.|:|.|||||.|  |..:|    ..:
 Worm   435 QVALVDFTYTNSVMVPNVTLFYKDEGGAV-WSYYGHSRPLDIPICGFLGKS--CPVSFWEQYKIL 496

  Fly   539 MYSVFGLLLFLGLVFLVICLLQKQMKLSKELN-NMSWRVRPDDVLIEMGGMFGSKGGLQRLDVEN 602
            ::....:::.:.|:.::.||.....|.::... |..|:| |...|||.......||..:|
 Worm   497 IFVAIAVIVLMVLIMIIGCLCVISGKRAERARINAEWQV-PFAKLIESEKQVRGKGASRR----- 555

  Fly   603 ISLQQFGI----HSGRASIASFTSLPPQVYTTIGQFKGERVAIKK---VNVKKVDLTPQLLWEIK 660
             |||....    |||..:::.|.    :.||.: .::.|.|...|   .::.|.|..     ...
 Worm   556 -SLQSAPSISTGHSGVTTVSDFC----ENYTMM-MYEKEMVLTAKYQYTHLTKADKE-----RFV 609

  Fly   661 QARDVSHENTVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMN 725
            :.|.:.|||..||:|..||...  .:.:|:.||||||:|:|......:|:.|...:|.|:.||:.
 Worm   610 KMRKLDHENINRFIGLSIDSAH--FISVTKLCSRGSLQDILSRGNFSMDYFFMFCIIRDVAKGLE 672

  Fly   726 YLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGLRTL----TTPSDFVRDQNYYLKLLWIAPELLP 786
            |||.:.:..||.|||..||::..:.:|::::|:..|    |.|..         :|||:|||:|
 Worm   673 YLHKTFLRLHGNLRSATCLVNDSWQVKLAEYGMDNLVEEQTPPKK---------RLLWVAPEVL- 727

  Fly   787 LTTIPGCCPATQ---RGDVYSFGIILEEIVNRGGPYQEARQQMDVHTILHKVRQCNGFRPLIRE- 847
                .|....:|   ..|:|||.||..||:.:...:....::.|...|::.|:: .|..|:..|
 Worm   728 ----RGSLSVSQMEPSADIYSFAIIASEILTKKEAWDILDRKEDCEEIVYNVKK-GGLFPIRPEI 787

  Fly   848 ----RECPPDLLELMEKCWADNQEERPTFSTIRSNIRTIMKGFCENLMDDLLNRMEQYANNLESL 908
                .:..|.|:.|::.|||:..|:|||...|.|.::.::.....||||.:.|.:|:|.:.||..
 Worm   788 ITDIHDVNPALIALVKDCWAEVPEDRPTAENICSQMKGLVSKQKTNLMDHVFNMLEEYTSTLEEE 852

  Fly   909 VEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPM 973
            :||:|::|:|||::.:.||.::||:.||::|.||..||||.|.|||::|||:|.||.|.::.||.
 Worm   853 IEERTKELTLEKKKADILLSRMLPKQVAERLKAGQTVEPEGFDSVTVFFSDVVKFTILASKCSPF 917

  Fly   974 DVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFN 1038
            ..||.||||||.||.||..:.|||||:|||.||.|||||..||..|.::|..|:|..:....|||
 Worm   918 QTVNLLNDLYSNFDTIIEQHGVYKVESIGDGYLCVSGLPTRNGYAHIKQIVDMSLKFMEYCKSFN 982

  Fly  1039 LRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILD 1103
            :.|.|...:::|||::||...|||||..||.||||||||||||||||.|:|..||:::...::|.
 Worm   983 IPHLPRENVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSLIHLTNDAHSLLT 1047

  Fly  1104 KF--GTFQMEQRGDVELKGKGTVTTYWLNSTSEGEARP---------PTPQILTTDEVPFP 1153
            ..  ..::...||:|.:||||.:.|:|::... ||..|         .||.:.....:|.|
 Worm  1048 THYPNQYETSSRGEVIIKGKGVMETFWVHGRF-GEMEPTELRSISNRSTPPVTNDRWIPNP 1107

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_GC-like	90..501	CDD:380575	103/472 (22%)
		Protein Kinases, catalytic domain	616..885	CDD:473864	82/283 (29%)
		HNOBA	<891..939	CDD:462234	20/47 (43%)
		CYCc	918..1109	CDD:214485	100/192 (52%)
gcy-1	NP_496039.1	PBP1_NPR_GC-like	35..451	CDD:380575	103/465 (22%)
		Protein Kinases, catalytic domain	555..821	CDD:473864	88/298 (30%)
		HNOBA	<839..883	CDD:462234	18/43 (42%)
		CYCc	862..1051	CDD:214485	100/188 (53%)