DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and gcy-22

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_508018.2	Gene:	gcy-22 / 180365	WormBaseID:	WBGene00001547	Length:	1058	Species:	Caenorhabditis elegans

Alignment Length:	1132	Identity:	337/1132 - (29%)
Similarity:	535/1132 - (47%)	Gaps:	185/1132 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 VYNVGVLMASHLDSPFDLE------RCGPAVDLALDEINKVFLKP----HNITLLKKKGSYPSCS 142
            |..||.|.|:  |:..:|.      :...|:.:|...|.:..|.|    .|:|.:     ..:|.
Worm    25 VLQVGFLAAN--DNTTELAPFIGWGQVAGALGVAWSRIVEYGLLPGYETMNLTWV-----LTNCR 82

  Fly   143 GARAPGLAADMYFQDDVIAFIGPACAFALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTSGIL 207
            .|.|.|...: |.:......:||.|....:....:|.|.:.|:|..   .||       ..|.:|
Worm    83 EADAVGSVIN-YAEGHAHVVLGPPCVRPAQVAGSVAKYLDFPLILW---GPP-------FDSSLL 136

  Fly   208 GRIHKWKNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNWNHVALL--VDRSEL----- 265
            .:.               :|||:...:............::..:.|..:||:  |.||:|
Worm   137 NQF---------------EYPTIASTTSSTLYQATSLIRLLEYYKWTEIALIYYVARSDLIPRCT 186

  Fly   266 -----FSWTVGKNLEYGLRQEGLLSFVKELNGNEEEVYENYLKDASMYARVVILSVRGVLVRK-F 324
                 |...|..|....:.....:|.:...:      |...|::....|||||:.:.....|: .
Worm   187 PLISDFEGLVNNNDNLTITYRRQMSVITNTS------YATALRNLKELARVVIVCLESDEARRNL 245

  Fly   325 MLAAHSLGMTNGEWVFLDVEI----FQSEYW-GDKGWEMKDEHDAKARKAYEALLRVSLLQPTSP 384
            |::....||...|:|::..|.    |.|.:| |..|     ::|...|.|.:.|
Worm   246 MISISENGMDGDEYVYIMAESRRAGFASSFWNGTDG-----KNDLALRAARKFL----------- 294

  Fly   385 KFQDFADNVRENALYDYNYTFGEGEEVNFF------------------IGAFYDGVYLLGMALNE 431
                    |.:|..|:...||.:.....|.                  :|...|.:.|...|||.
Worm   295 --------VMDNQKYNDTTTFVQEVRAAFSRPPFSCPNCTNIDPTVSQVGPLGDALLLYAYALNR 351

  Fly   432 TLTEGGDIRDGVNITRRMWNRTFEGITGHVRIDDNGDRDADYSILDLDPINGKFSV--------- 487
            ::..|.....|...........|.|.||.|.|:.|..|...:.:.:||..:.:..|
Worm   352 SIATGNPNPTGTEFCEVAKGMEFLGFTGKVIINQNSTRTPLFVVYNLDSTDKEMIVMQITEDLDD 416

  Fly   488 ----VAHYSGVHKVYSAVHGKKIHWPGGREEPPPDVPPCGFLGNSTDCVGNFSTIMYSVF----- 543
                ||  |.|:...:.|......|.......|...|.|||.|  |||..:|:....::.
Worm   417 SKDPVA--SSVNYYITLVATPAQIWDTWGGTVPLSTPICGFTG--TDCPKSFTDQYLAIILGCTA 477

  Fly   544 -GLLLFLGLVFLVICLLQKQMKLSKELNNMSWRVRPDDVLIEMGGMFGSKGGLQRLDVENISLQQ 607
             .|:|.:.::..::.|::.:.:..:.||.: |:|.           |.|   |.:...:|.
Worm   478 AALVLIIAVISTIVFLVRSKRQEEERLNQL-WQVH-----------FSS---LVKPPQKNT---- 523

  Fly   608 FGIHSGRASIASFTSLPPQVYTTIGQFK-----------GERVAIKKVNVKKVDLTPQLLWEIKQ 661
              :||.|:..::.|:   ....||...|           .:.|..:|.|. :...|.......::
Worm   524 --MHSSRSLQSTVTT---STKVTINSKKDTERHSFYFLNNDSVVARKHNF-RATFTKNDRAMFRK 582

  Fly   662 ARDVSHENTVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNY 726
            .|:|.::|..:|:|..:|  .||::.:..|||||||:||:...::::||.|:.||:.|:...:.|
Worm   583 MRNVDNDNLCKFIGLSLD--SPTLISIWRYCSRGSLQDVIAKGSLQMDWFFKYSLMRDVADAIYY 645

  Fly   727 LHNSDVAAHGKLRSCNCLIDGRFVLKISDFGLRTLTTPSDFVRDQNYYLKLLWIAPELLPLTTIP 791
            ||:|.:..||.|.|..||:|.|:.:|:|.|||..:....  |::|..:|.   .|||.:..|.:
Worm   646 LHHSPIGPHGWLSSSTCLVDERWQVKVSFFGLSAIKQYE--VKEQRDFLH---TAPEHIRDTNL- 704

  Fly   792 GCCPATQRGDVYSFGIILEEIVNRGGPYQEARQQMDVHTILHKVRQCNGFRP----LIRERECPP 852
               |.|:..|:|||.||..|::.:...:....:..|:..:::|::: .|..|    |..|.|...
Worm   705 ---PITKEMDIYSFAIICSELITKKSAWDLENETFDIEELVYKIKK-GGRSPPRPSLETEDEHNG 765

  Fly   853 DLLELMEKCWADNQEERPTFSTIRSNIRTIMKGFCENLMDDLLNRMEQYANNLESLVEEKTRQLS 917
            .:..|:..||.:|.::|||...|::.::::......||||.:.|.:||||:|||..|:.:.::|:
Worm   766 SMSLLVRDCWNENPDQRPTSEQIKTLMKSMNHNRSSNLMDHVFNVLEQYASNLEDEVQARMKELT 830

  Fly   918 LEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDL 982
            .||:|::.|||::||:.||::|..|..||||.|..|||:|||:|.||.|.:|.:|:.|||.||||
Worm   831 EEKKRSDVLLYRMLPKQVAEKLKLGQSVEPETFDCVTIFFSDVVSFTTLASRCTPLQVVNLLNDL 895

  Fly   983 YSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKI 1047
            |:|||.||..:||||||||||.||.|||||..||::||:||:.|:..:|:|:.:|.:.|.|:.:|
Worm   896 YTTFDAIIEQHDVYKVETIGDGYLCVSGLPHRNGNEHAKEISSMSFSLLKAIKTFRVPHLPKERI 960

  Fly  1048 QIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSS-ATKAILDKFGTFQME 1111
            .||:|:|:|.|..||||..||.||||||:|||||||||.|:||::|:|: ..|.:.:..|.:|.|
Worm   961 NIRVGLHTGPVVTGVVGMTMPRYCLFGDSVNTASRMESNGKPGRVHISTECMKFLTEVIGGYQTE 1025

  Fly  1112 QRGDVELKGKGTVTTYWLNSTSEGEAR 1138
            .||:|.:||||.|.|:||.:..|.||:
Worm  1026 PRGEVIVKGKGAVQTHWLLTDDEIEAK 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	95/464 (20%)
		ANF_receptor	107..479	CDD:279440	82/411 (20%)
		PKc_like	616..885	CDD:304357	79/283 (28%)
		TyrKc	627..877	CDD:197581	78/264 (30%)
		HNOBA	<882..939	CDD:285003	24/56 (43%)
		CYCc	918..1109	CDD:214485	106/191 (55%)
		Guanylate_cyc	945..1131	CDD:278633	107/186 (58%)
gcy-22	NP_508018.2	Periplasmic_Binding_Protein_Type_1	28..408	CDD:299141	90/442 (20%)
		ANF_receptor	48..399	CDD:279440	82/411 (20%)
		PKc_like	553..795	CDD:304357	75/254 (30%)
		HNOBA	<791..852	CDD:285003	24/60 (40%)
		CYCc	831..1023	CDD:214485	106/191 (55%)
		Guanylate_cyc	858..1044	CDD:278633	106/185 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7809
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020