DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and daf-11

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_505960.3	Gene:	daf-11 / 179605	WormBaseID:	WBGene00000907	Length:	1077	Species:	Caenorhabditis elegans

Alignment Length:	1018	Identity:	268/1018 - (26%)
Similarity:	437/1018 - (42%)	Gaps:	209/1018 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 KYPTLTRM-SYCQCRLILVFASVIRQFNWNHV-ALLVDR--------SELFSWTVGKNLEYGLRQ 280
            ::||:..| :.....|.....|::|.|.|..| |:|.:.        ||::..|:
Worm    33 EHPTMIDMVTRSPQNLAQNLVSLLRGFEWGQVGAVLCEECYEGDELASEIYFSTI---------- 87

  Fly   281 EGLLSFVKELNGNEEEVYEN------------------YLKDA----SMYARVVILSVRGVL--V 321
                          |:::||                  .:.||    ...|||::|.:...|  .
Worm    88 --------------EDIFENNNIALKETVRIGKRENSVNISDAITIFEPSARVILLFLGNKLNDY 138

  Fly   322 RKFMLAAHSLGMTNGEWVFLDVEIFQSEYWGDKGWEMKDEHDAKARKAYEALLRVSLLQPTSPKF 386
            .:||.|......|..|:..: :.|.::.......|:   |:||.|....:|::..:.....| |.
Worm   139 TEFMTAMSMNNYTTEEYTPV-IVISKNSLELTFPWK---ENDAIAELFDKAIIVYNNCYDKS-KI 198

  Fly   387 QDFADNVRENALYDYNYTFGEGEEVNFFIGAFYDGVYLLGMALNETLTEGGDIRDGVNITRRMWN 451
            ..|..          :|:|...||....: ..|:|.:|||..|...:| ...:.:.|...:.:.:
Worm   199 SSFLS----------SYSFSTIEETIISL-QMYEGYHLLGYYLYTAIT-NTTLFNYVQPEKAISS 251

  Fly   452 RTFEGITGHVRIDDNGDRDADYSILDLDPINGKFSVVAHYSGVHKVYSAVHGKKIHWPGG----- 511
            .:..|..|.:.|:.||.|.|.|.:|.:|                   .:::......|.|
Worm   252 MSIPGPFGEIFINSNGQRIAGYDVLVVD-------------------KSLNSNNFIMPLGTISTD 297

  Fly   512 -----------------REEPPPDVPPCGFLGNSTDCVGNFSTIMYSVFGLLLFLGLVFLVICLL 559
                             ..||..|||.|||.|...|..|....|...:..||:|:    :::..:
Worm   298 KKCPDQACLNFVLNSTSSFEPLKDVPLCGFHGEICDQTGVIIAIAVIMGVLLMFI----IILTTI 358

  Fly   560 QKQMKLSK--ELNNMSWRVRPDDV-LIEMGGMFGSK----GGLQRLDVENISLQQFGIHSGRASI 617
            :|....||  .::| .|.:...|| .|::....||:    ..|||...|...||........|::
Worm   359 RKCCNGSKGRSISN-PWVIPFQDVRFIDLTNTEGSQHMSIQSLQRNMEEKQRLQSLARTKHIATV 422

  Fly   618 ASFTSLPPQVYTTIGQFKGERVAIKKVNVKKVDLTPQLLWEIKQARDVSHENTVRFVGACIDLPR 682
                   .|||....::    |...|:...|:|:  .||:::|.  .:.|:|...|||..|| ..
Worm   423 -------DQVYVLADKY----VMRDKLRYDKIDI--NLLYQMKS--HLQHDNLNSFVGITID-KA 471

  Fly   683 PTVLILTEYCSRGSLKDVLENEAIE--LDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLI 745
            ..:.|:...|.||||.|.:..:..:  ....|....:.||:||:.|:|.|.:..||.|...||::
Worm   472 SHMYIIWNQCFRGSLHDHIFTKERQRGTATRFEGLFLRDILKGLEYIHASAIDFHGNLTLHNCML 536

  Fly   746 DGRFVLKISDFGLRTL-----TTPSDFVRDQ---------NYY---LKLLW-----------IAP 782
            |..:::|:|.||:..|     |:...|..|.         :|:   :|.:|           |.|
Worm   537 DSHWIVKLSGFGVNRLLVKWKTSGQIFTEDHTPVIKSEELHYFDPAMKKIWKNYADRNERALITP 601

  Fly   783 ELLPLTTIPGCCPATQRGDVYSFGIILEEIVNR--------GGPYQEARQQMDVHTILHKVRQCN 839
            :.            .::.|:||||:||.||:.:        ..|.:|     |...::.......
Worm   602 QF------------GKKCDMYSFGVILHEIILKKKFVEQLFDSPREE-----DDSVLIDDENDAI 649

  Fly   840 GFR---PLIRER--ECPPDLLELMEKCWADNQEERPTFSTIRSNIRTIMKGFCENLMDDLLNRME 899
            ..|   |:|...  |...||::::|.|:.   ..||..:..|..|.|::| ...:|:|.::..:.
Worm   650 ASRFPLPIIIPEGIEMHNDLIKMLENCFG---SVRPDIALARKIIDTVLK-MSGSLVDLMIKNLT 710

  Fly   900 QYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFT 964
            .|...|...|:.:|.:|..|:::.::||.::||:.||..|..|..|:|:.:.:.||.:|||||||
Worm   711 AYTQGLNETVKNRTAELEKEQEKGDQLLMELLPKSVANDLKNGIAVDPKVYENATILYSDIVGFT 775

  Fly   965 ELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALD 1029
            .||::|.||:||..|:.:|..||.||.....||:|||||||.|.:|||......|.:.|.::||.
Worm   776 SLCSQSQPMEVVTLLSGMYQRFDLIISQQGGYKMETIGDAYCVAAGLPVVMEKDHVKSICMIALL 840

  Fly  1030 ILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHV 1094
            ....:..|.:.|:|...:..|.|.:||.|.|||:|:|.|.|..||:.|..||:|||:|...:|.:
Worm   841 QRDCLHHFEIPHRPGTFLNCRWGFNSGPVFAGVIGQKAPRYACFGEAVILASKMESSGVEDRIQM 905

  Fly  1095 SSATKAILDK-FGTFQMEQRGDVELKGKGTVTTYWLNSTSEGE 1136
            :.|::.:|:: |..|....||...::|.|.:.||||...:.||
Worm   906 TLASQQLLEENFPQFVCSNRGGRTIEGIGRILTYWLEGVNAGE 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	61/303 (20%)
		ANF_receptor	107..479	CDD:279440	60/286 (21%)
		PKc_like	616..885	CDD:304357	76/311 (24%)
		TyrKc	627..877	CDD:197581	72/292 (25%)
		HNOBA	<882..939	CDD:285003	15/56 (27%)
		CYCc	918..1109	CDD:214485	78/191 (41%)
		Guanylate_cyc	945..1131	CDD:278633	78/186 (42%)
daf-11	NP_505960.3	Periplasmic_Binding_Protein_Type_1	<33..295	CDD:299141	63/321 (20%)
		PKc_like	447..695	CDD:304357	69/270 (26%)
		HNOBA	<714..750	CDD:285003	11/35 (31%)
		CYCc	729..922	CDD:214485	79/192 (41%)
		Guanylate_cyc	756..943	CDD:278633	78/186 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910