Protein Alignment CG3216 and gcy-7

DIOPT Version :9

• Sequence 1: NP_726013.2
• Gene: CG3216 / 37376
• FlyBaseID: FBgn0034568
• Length: 1161
• Species: Drosophila melanogaster
• Sequence 2: NP_001360539.1
• Gene: gcy-7 / 179222
• WormBaseID: WBGene00001534
• Length: 1117
• Species: Caenorhabditis elegans
• Alignment Length: 1163
• Identity: 363/1163 - (31%)
• Similarity: 562/1163 - (48%)
• Gaps: 224/1163 - (19%)

  Fly    83 GSTMRVYNVGVLMASHLDS-PFDL--ERCGPAVDLALDEINKVFLK---PHNITLLKKKGSYPSC 141
            |:|..|..||.:......| |..:  .....|..:|:|.:.:..|.   ..|.|:     .:..|
 Worm    29 GTTGNVIRVGFIHCRDFQSAPITVGYRTSAAAASIAVDRLKRENLMSGWEFNFTI-----EFDDC 88

  Fly   142 SGARAPGLAADMYFQDDVIAFIGPACAFALEPVARLAA-----YWNKPIITGMGDQPPSSEGELT 201
            ..:.|.|:..|:..:.:|...|||...   :|.  |||     |:|:|||.
 Worm    89 VESEAAGMTVDLIEKHNVDVIIGPTMN---QPT--LAAFIVSNYFNRPIIA-------------- 134

  Fly   202 VTSGILGRIHKWKNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNWNH----------- 255
                       |...|.....|..::|....:|..|..|.:...:|::::.|:.
 Worm   135 -----------WGLVNAAQLDDFERFPNAGILSAGQRSLGVAIRAVLKRYEWSQFVYAYFTEEDT 188

  Fly   256 ---VALLVDRSELFSWTVGKNLEYGLR-----QEGLLSFVKELNGNEEEVYENYLKDASMYARVV 312
               |.:..|..::.|:.....|.|.::     .:|::..:|::...               .|::
 Worm   189 EKCVTMRNDLQQVVSYFGDIILAYSIQVADISNDGMIEALKKIQSR---------------GRII 238

  Fly   313 ILSVR-GV-LVRKFMLAAHSLGMTNGEWVFLDVEIFQSEY------WGDK-GWEM---KDEHDAK 365
            :..:: |: |.||::|||...||...|:|::..:|....|      .|:: .|.:   .||:|.:
 Worm   239 VTCMKDGIGLRRKWLLAAEEAGMIGDEYVYVFSDIKSKGYVVPLLGGGERPSWILSTGSDENDTR 303

  Fly   366 ARKAYEALLRVSLLQPTSPKFQDFADNVRENALYDYNYT-FG------------------EGEEV 411
            |.||::..:.:             .|.:.:.::.. ||| ||                  |||
 Worm   304 ALKAFKQSIFI-------------CDMMGQGSIAT-NYTIFGQEIIARMKEAPYFCTKDCEGE-- 352

  Fly   412 NFFIGAFY-----DGVYLLGMALNETLTEGGDIRDGVNIT--RRMWNRTFEGITGHVRIDDNGDR 469
            ||.:.|.|     |.||..|:||::.| :.|.|....|.|  .|.:.::|.|::|:|.|::.|.|
 Worm   353 NFTVAATYAGQLHDAVYAYGVALDKML-KAGQIAQYRNATAFMRYFPQSFIGMSGNVTINEKGTR 416

  Fly   470 DADYSILDLDPINGKFSVVAHY-SGVHKVYSAVHGKK-IHWPGGREEP-PPDVPPCGFLGNSTDC 531
            :....:|.||..|....:...| ..:...::|::..: :.|...:... |.|||.|||.||.  |
 Worm   417 NPTLFLLALDENNNNTRMATIYVENMSATFNALYSDEGVMWASRKNNARPVDVPLCGFTGNL--C 479

  Fly   532 VGNF---STIMYSVFGLLLFL-------GLVFLVICLLQKQMKLSKELNNMSWRVRPDDVLIEMG 586
            ..:|   ..|...|..::|||       |:.|.:    |.:.:..:.||.: |::
 Worm   480 PKSFVDEYLIWVIVAIVVLFLAITAAACGIYFSI----QARRQEIERLNRL-WQI---------- 529

  Fly   587 GMFGSKGGLQRLDVENISLQQFG--------IHSGRASIASFTSLPPQVYTTIGQFKGE------ 637
                     ..:.:..|:.:|.|        :.||.::::|.|::         .||.|
 Worm   530 ---------PFIHLHQINSKQKGKGEHSVRSLQSGTSTLSSRTTV---------SFKTESRNFLF 576

  Fly   638 -----RVAIKKVNVKKVDLTPQL----LWEIKQARDVSHENTVRFVGACIDLPRPTVLILTEYCS 693
                 ....:.|..||....|:|    ...::..|::..:|..||:|.|:|  .|.:|.:..:||
 Worm   577 FSLQRESDYEPVVAKKHAYRPRLDDDKCTFMRSLRNLDQDNLNRFIGLCLD--GPQMLSVWRFCS 639

  Fly   694 RGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGL 758
            |||:.||:....|::|..|..|||.|:|.|:.:||.|.|..||.|.|..||||.|:.:|||::||
 Worm   640 RGSIADVILKATIQMDNFFIYSLIKDMVHGLVFLHGSMVGYHGMLTSKCCLIDDRWQVKISNYGL 704

  Fly   759 RTLTTPSDFVRDQNYYLKLLWIAPELLPLTTIPGCCPATQRGDVYSFGIILEEIVNRGGPYQEAR 823
            :.|.:|..:.:..     |||.|||||....|.|    ::.|||||.|||..|::.|.|.:....
 Worm   705 QDLRSPEMYEKKD-----LLWSAPELLRAEDIKG----SKEGDVYSLGIICAELITRKGVFNMED 760

  Fly   824 QQMDVHTILHKVRQCNGF---RPLI---RERECPPDLLELMEKCWADNQEERPTFSTIRSNIRTI 882
            ::.|...|::.::: .|.   ||.:   ...|..|.||.|:..|:.:...|||:..|:||.:|.:
 Worm   761 RKEDPEEIIYLLKK-GGLKSPRPDLEYDHTIEINPALLHLVRDCFTERPSERPSIETVRSQLRGM 824

  Fly   883 MKGFCENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEP 947
            .....:||||.:.|.:|.||::||..|.|:|::|..||::::.|||::||:.||.:|..|..|||
 Worm   825 NSSRNDNLMDHVFNMLESYASSLEEEVSERTKELVEEKKKSDVLLYRMLPKTVADKLKLGQTVEP 889

  Fly   948 EEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLP 1012
            |.|..|||:|||:|.||.|.::.:|:.|||.|||||:.||.||..:||||||||||.||.|||||
 Worm   890 ETFEQVTIFFSDVVQFTTLASKCTPLQVVNLLNDLYTIFDGIIEKHDVYKVETIGDGYLCVSGLP 954

  Fly  1013 EPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTV 1077
            ..||::|.|:||||:|..|.::..|.:.|.|..:|.:||||:.|||.|||||..||.:|||||.|
 Worm   955 HRNGNEHVRQIALMSLAFLSSLQFFRVPHLPSERINLRIGMNCGSVVAGVVGLTMPRFCLFGDAV 1019

  Fly  1078 NTASRMESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVELKGKGTVTTYWLNSTSEG 1135
            ||||||||.|:|||||||:....:|...|.|..|.||:|.:||||.:.|:||.....|
 Worm  1020 NTASRMESNGKPGKIHVSAEANRMLHLVGGFDTESRGEVIIKGKGVMETFWLTGQGTG 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	102/474 (22%)
		ANF_receptor	107..479	CDD:279440	94/436 (22%)
		PKc_like	616..885	CDD:304357	94/289 (33%)
		TyrKc	627..877	CDD:197581	89/270 (33%)
		HNOBA	<882..939	CDD:285003	23/56 (41%)
		CYCc	918..1109	CDD:214485	108/190 (57%)
		Guanylate_cyc	945..1131	CDD:278633	109/185 (59%)
gcy-7	NP_001360539.1	PBP1_NPR_GC-like	36..438	CDD:380575	101/468 (22%)
		PKc_like	550..822	CDD:389743	95/292 (33%)
		CYCc	860..1049	CDD:214485	107/188 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I5035
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020