DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and acy-4

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_504486.4	Gene:	acy-4 / 178949	WormBaseID:	WBGene00000071	Length:	1013	Species:	Caenorhabditis elegans

Alignment Length:	1262	Identity:	248/1262 - (19%)
Similarity:	411/1262 - (32%)	Gaps:	454/1262 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 QRMYERSRESKSTQLSRYTEVGEMGSTMR-VYNVGVL----MASHLDSPFDLERCGPAVDLALDE 118
            :|.|...|..|.|::::.....:..|||| .:...||    |.:.::.|            :|||
Worm     3 ERAYNSIRAHKQTRVAQRPVSKKTSSTMRETFGSQVLRELEMKNRMECP------------SLDE 55

  Fly   119 INKVFLKPHNITLLKKKGSYPSCSGARAPGLAADMYFQD-----------DVIAFIGPACAFALE 172
            |...:..|.      :|..|...|..:........||:.           .:::......||
Worm    56 ILSFYHFPW------EKLRYRKNSQKKKRSTLYSFYFEQVNSGRIQFSFVILLSICISEAAF--- 111

  Fly   173 PVARLAAYWNKPIITGMGDQPPSSEGELTVTSGILGRIHKWKNE---------------NTGM-- 220
              :...|.|.|.:|..:          ||:...||...|..:.|               .|.|
Worm   112 --SAFGAEWLKSLILCI----------LTLVISILSFFHAKRTELVCIASIISCVIISACTSMRT 164

  Fly   221 -------FKDKSKYPTLTRMSYCQCRLILVFASVIRQFNWNHVALLVDRSELFSW---------- 268
                   |...|..|    ||:    ::::|::....|....:.:|:|.:..|..
Worm   165 SVTYLLIFSTYSLLP----MSF----MLMIFSTFALTFLVAFIGVLMDYNVGFDIILTRVMMVIL 221

  Fly   269 --TVGKNLEYGLRQEGLLSFVKELNGNEEE--VYENYLKDASMYARVVILSVRGVL-------VR 322
              .||..:.|.      ..||:....:|..  |....|.|..|:.:..||  ..||       |:
Worm   222 VNVVGSLVYYP------TEFVQRKTFHETRKCVQSRMLLDKEMHRQEKIL--LAVLPKNIAFEVK 278

  Fly   323 KFMLAAHSLGMTNGEWV--FLDVEIFQSEYWGDKGWEMKDEHDAKARKAYEALLRVSLLQPTSPK 385
            |.|...|...|.:..::  :.|:.|..::..|..  .:..|::.|     :.:|.::.|.....|
Worm   279 KDMQETHEERMFHKIYIRKYEDISILFADICGFT--NLASEYNPK-----DLVLMLNELFARFDK 336

  Fly   386 FQDFADNVRENALYD-YNYTFGEGEEVNFFIGAFYDGVYLLGMALNETLTEGGDIRDGVNITRRM 449
            .......:|...|.| |....|..|             |....|:| |:..|.|:.:.:.:.|.|
Worm   337 VASIHQCMRIKILGDCYYCVCGVPE-------------YQKNHAIN-TVEMGRDMIEAIRLVREM 387

  Fly   450 ------------------------------WNRTFE--------GITGHVRIDD----------- 465
                                          |:....        |:.|.|.|.|
Worm   388 TLVNVNMRVGIHTGKAHCGVLGLKKWQFDVWSNDVTLANQMESGGLAGRVHITDATRSYLKGAYI 452

  Fly   466 ----NG------------------DRDADYSILDLDPINGKFSVVAHYSGVHKVYSAVHGKKIHW 508
                ||                  ||..||..:..:..|                   |...:.|
Worm   453 LEEGNGGSRSKFLEKEKIKTWLVVDRSPDYDNICQEATN-------------------HPVMVPW 498

  Fly   509 PGGREEPPPDVPPCGFLGNSTDCVGNFSTIMYSVFGLLLFLGLVFLVICLLQKQMKLSKELNNMS 573
            ...|.                                             :.||    :.|..||
Worm   499 KSTRG---------------------------------------------ISKQ----ERLTGMS 514

  Fly   574 WRVR---------PDDVLIEMGGMFGSKGGLQRLDVENISLQQFGIHSGRASIASFTSLPPQVYT 629
            .|.|         .::||:|..... .:.|:|.:..||...    :|....|:
Worm   515 TRTRGASTRNGLSEEEVLVENVDSH-LRQGIQAIHQENWKT----MHCKNWSL------------ 562

  Fly   630 TIGQFKGERVAIKKVNVKKVDLTPQL-LWEIKQARDVSHENTVRFVGACIDLPRPTVLILTEYCS 693
               ::|..||..|.|.:|..|:..|: |:             |..|..||
Worm   563 ---KYKQVRVENKFVRLKYKDIPFQVTLY-------------VAIVAICI--------------- 596

  Fly   694 RGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGL 758
              .:|..|.|   .:.::|...:...:...|.::....:..|.:|.|  .:|...|:|......:
Worm   597 --GIKFGLMN---LVSFSFVPQMFIVLTSVMIFILTRALIKHARLVS--LVIGVLFILLSIQIVI 654

  Fly   759 RTLTTPSDFVRD-----QNYYLKLLWIAPELLPLTTIPGCCPATQRGDVYSFGIILEEIVNRGGP 818
            ......|.|..|     :|.|....    |:..:.|:..|             :||
Worm   655 LMGMYESKFTCDVEKCFKNNYTDFF----EIFEICTLATC-------------VIL--------- 693

  Fly   819 YQEARQQMDVHT---------------ILHKVRQCNGFRPLIR--ERECPPDLLELMEKCWADNQ 866
                  .:|..|               |..|:.:.|.:..|:.  ...|....|.|:
Worm   694 ------SVDFMTKLLMSMIYFSSFTVLITAKLIRINQYEALLSTYANFCVLSCLTLL-------- 744

  Fly   867 EERPTFSTIRSNIRTIMKGFCENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQIL 931
              ...|||.||               :|::|.: :...|::|.|:  .|:..:.::...:|..||
Worm   745 --LVVFSTRRS---------------ELISRYD-FIWKLQALDEQ--LQMKRKHEQNRSVLENIL 789

  Fly   932 PRPVAQQLMAGDLVEPEEFSSVT-----------IYFSDIVGF----TELCARSSPMDVVNFLND 981
            |..||:..:       |:.:||:           |.|:.:..|    .|....:..::.:..||:
Worm   790 PSHVAKHFV-------EDATSVSKLYHESRDNACIMFATLTEFDKFYIECDGNNEGVECLRLLNE 847

  Fly   982 LYSTFDRIIG-------FYDVYKVETIGDAYLVVSGLP--EPNGDKHAREIALMALDILRAVSSF 1037
            :.|.||:|:.       |..:.|::||...|:|.|||.  |...:.|...|||.|.::|..:.|.
Worm   848 IISDFDQILDQILDREEFKKIEKIKTISTTYMVASGLAGRECGDNSHVEAIALFARELLVKLEST 912

  Fly  1038 NLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAIL 1102
            |:.....:  .:|||::.|.|.|||:|...|||.::|::||.||||:|.|..|:|.|:...|:||
Worm   913 NIHSFNNF--NLRIGINVGPVVAGVIGSDKPHYDIWGNSVNVASRMDSGGVAGRIQVTEEVKSIL 975

  Fly  1103 DKFGTFQMEQRGDVELKGKGTVTTYWL 1129
            :..| :..|.||.:.:||||.:.|::|
Worm   976 EPLG-YNFECRGQINVKGKGMMETFFL 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	92/539 (17%)
		ANF_receptor	107..479	CDD:279440	87/501 (17%)
		PKc_like	616..885	CDD:304357	49/291 (17%)
		TyrKc	627..877	CDD:197581	46/272 (17%)
		HNOBA	<882..939	CDD:285003	12/56 (21%)
		CYCc	918..1109	CDD:214485	65/214 (30%)
		Guanylate_cyc	945..1131	CDD:278633	68/209 (33%)
acy-4	NP_504486.4	AC_N	<50..291	CDD:292831	54/289 (19%)
		CYCc	260..451	CDD:214485	37/213 (17%)
		Guanylate_cyc	293..448	CDD:278633	28/175 (16%)
		CYCc	778..984	CDD:214485	65/215 (30%)
		Guanylate_cyc	807..1003	CDD:278633	65/198 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810