Protein Alignment CG3216 and gcy-18

DIOPT Version :10

• Sequence 1: NP_726013.2
• Gene: CG3216 / 37376
• FlyBaseID: FBgn0034568
• Length: 1161
• Species: Drosophila melanogaster
• Sequence 2: NP_502449.2
• Gene: gcy-18 / 178237
• WormBaseID: WBGene00001543
• Length: 1113
• Species: Caenorhabditis elegans
• Alignment Length: 1196
• Identity: 352/1196 - (29%)
• Similarity: 544/1196 - (45%)
• Gaps: 274/1196 - (22%)

  Fly    63 ERSRESKST-QLSRYTEVGEMGSTMRVYNVGVLMASHLDSPFDLERCGPAVDLALDEINKVFLKP 126
            |.::|.|.. ::.....||.|.:..|:.|:         |..:|...|    |..|:|
 Worm    44 EVNKEHKRVIKIGHIGAVGVMPNDARILNI---------SKENLIEEG----LVGDDI------- 88

  Fly   127 HNITLLKKKGSYPSCSGARAPGLAADMYFQDDVIAFIGPACAFALEPVARLAAYWNKPIITGMGD 191
             ...::.::....|..|.   .:||::|....|.|||||.||..||.|.::|.:||.|||:
 Worm    89 -EFEIVSRQACSESFEGV---AVAAELYHVHQVRAFIGPYCAAELEAVTKMATFWNIPIIS---- 145

  Fly   192 QPPSSEGELTVTSGILGRIHKWKNENTGMFKDKSKYPTLTRMSYCQCRLIL-VFASVIRQFNWNH 255
                       .|.:...:           .|:|.|.||.|:|......|. ...:::..:.|..
 Worm   146 -----------YSSVPNAV-----------SDRSVYKTLARVSSKNTNSIAEATVALLLHYKWLK 188

  Fly   256 VALLV-------DRSELFSWTVGKNLEYGLRQEGLLSFVKELNGNE-----EEVYENYLKDASMY 308
            ||:..       :|..:|        |..:.:|| ::.||::..:|     |.:....|.|.:..
 Worm   189 VAIATNTGSTAFERVSIF--------EEIMHREG-VTIVKKVMFDENTDANEMMNSGQLGDLAAN 244

  Fly   309 ARVVI--LSVRGVLVRKFMLAAHSLGMTNGE-----------------WVFLDVEIFQSEYWGDK 354
            ||::|  .|....|.::||.|.:::.|.|.|                 |:..|.|:.|
 Worm   245 ARIIICLFSSTKELSKEFMQATYTMRMNNAEYAYIIPWLQSGTKDLTPWIGADGEMLQ------- 302

  Fly   355 GWEMKDEHDAKARKAYEALLRVSLLQPTSPKFQD-----FADNVRENALY--DYNYTFGEGEEVN 412
              .:|| |.|.|           ::......|.|     |.:.:.::.:.  |.:.|     .:|
 Worm   303 --RVKD-HYANA-----------IIVDDVNGFDDSVVSSFVEKIEKHGMQKSDIDVT-----NIN 348

  Fly   413 FFIGAFYDGVYLLGMALNETLTEGGD---IRDGVNITRRMWNRTFEGIT--------------GH 460
            .::..| |.:.|..:|:.:.|.|..:   :.:|..|..||....|||:.              |.
 Worm   349 GYLHLF-DSLKLYALAIRKVLNETDNEAYVTNGQFIWNRMRRMKFEGVVSRSSSEENKDAGAIGT 412

  Fly   461 VRIDDNGDRDADYSILDLDP--------INGKFSVVAHYSGVHKVYSAVHGKKIH------WPGG 511
            |.:||..||...:|...:.|        :|.:..::::..|: |..|.....||:      ||..
 Worm   413 VLMDDVADRAPIFSAFYISPNRDKVMKMVNMESELISNCDGL-KNKSGCFQLKINDIKSGFWPSE 476

  Fly   512 REEPPPDVPPCGFLGNSTDCVGNFSTIMYSVFGLLLFLGLVFLVICLLQKQMKLSKELNNMSWRV 576
            ....|.|.|.||:.|.....:     :..||..|::.|.|:.:|...|.:..: :|:|..|.||:
 Worm   477 DGSMPLDEPICGYRGQRCSYL-----LEISVGSLIILLILISVVFFFLFRYCE-NKQLEKMPWRI 535

  Fly   577 RPDDVLIEMGGMFGSKGGLQRLDVENI-SLQQFG--------IHSGRASIASFTSLPPQVYTTIG 632
            ..||              ||.:|.|.: |:...|        |.:|:...|   .:....:||..
 Worm   536 FHDD--------------LQFIDEEQVKSMMSVGSVTTKLSNIQTGQKQHA---IIGVNTHTTYH 583

  Fly   633 QFKGERVAIKKVNVKKVDLTPQLLWEIKQARDVSHENTVRFVGACIDLPRPTVLILTEYCSRGSL 697
            ::| :|..||.:   |.|:  |||.::|||   .|:|...|:||..: .:..:|:|.::||||::
 Worm   584 RYK-QRRPIKFI---KEDM--QLLTQMKQA---VHDNLNPFLGAAFN-EKEEMLVLWKFCSRGTI 638

  Fly   698 KDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGLR--- 759
            :|::.|..:.||..|..:.:.||..|:.|||.|.:..||.|....||||..:::|:||:|:.
 Worm   639 QDIIYNANVVLDEKFHGAFVRDITLGLEYLHASPIGYHGSLTPWCCLIDRNWMVKLSDYGIANPL 703

  Fly   760 -----------TLTTPSDFVRDQNYYLKLLWIAPELL-----------PLTTIPGCCPATQRGDV 802
                       .....||.....:....::::|||||           ..:.:.......|.||:
 Worm   704 ERWEKQGAIEIAAAKDSDDKSQASQATSIIYMAPELLKNRETNKRRGMDQSWVKQSMLRRQAGDI 768

  Fly   803 YSFGIILEEIVNRGGPYQ---------------------EARQQMDVHTILHKVRQCNGFRPLIR 846
            ||||:::.||:.|..|::                     |.:.||.:|
 Worm   769 YSFGMVMYEILFRSLPFRDNTNISELVDYLADGSKTVSPEIQNQMGLH----------------- 816

  Fly   847 ERECPPDLLELMEKCWADNQEERPTFSTIRSNIRTIM--KGFCENLMDDLLNRMEQYANNLESLV 909
                 |||..|:..||::|.|.||:...:|.|...::  ||   :|:|.::..|||||||||.||
 Worm   817 -----PDLNALLRDCWSENPEIRPSIRRVRLNTEMVLKTKG---SLVDQMMKMMEQYANNLEKLV 873

  Fly   910 EEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMD 974
            .|:|..|.....|.::||.|:||..||.:|..|..|.|:.:||.||.||||||||.:|:.|:|::
 Worm   874 AERTGMLEEANIRADQLLTQLLPAYVANELKMGRSVAPKLYSSATILFSDIVGFTTICSGSTPLE 938

  Fly   975 VVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNL 1039
            |||.||.||:.||..|.....||||||||||:||||:||.|...|:|.||..|||:.:.::.:.:
 Worm   939 VVNMLNGLYTGFDECITRNKSYKVETIGDAYMVVSGIPEENEYNHSRNIANTALDMRQYLTGYQI 1003

  Fly  1040 RHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVS-SATKAILD 1103
            .|:|.::::.|.|.|:|||.|||||...|.|||||||||.:|||||||.||.|.:| .|...|..
 Worm  1004 PHRPTHRVRCRWGFHTGSVAAGVVGLTCPRYCLFGDTVNVSSRMESTGTPGMIQMSEEAHMHIRA 1068

  Fly  1104 KFGTFQMEQRGDVELKGKGTVTTYWL 1129
            ....|...:||:|::|||||..|:||
 Worm  1069 HHPVFTTTERGEVQVKGKGTCRTFWL 1094

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_GC-like	90..501	CDD:380575	103/474 (22%)
		Protein Kinases, catalytic domain	616..885	CDD:473864	83/316 (26%)
		HNOBA	<891..939	CDD:462234	23/47 (49%)
		CYCc	918..1109	CDD:214485	97/191 (51%)
gcy-18	NP_502449.2	PBP1_NPR_GC-like	64..446	CDD:380575	102/467 (22%)
		Protein Kinases, catalytic domain	549..846	CDD:473864	87/331 (26%)
		CYCc	882..1073	CDD:214485	97/190 (51%)