Protein Alignment CG3216 and gcy-8

DIOPT Version :10

• Sequence 1: NP_726013.2
• Gene: CG3216 / 37376
• FlyBaseID: FBgn0034568
• Length: 1161
• Species: Drosophila melanogaster
• Sequence 2: NP_501324.2
• Gene: gcy-8 / 177584
• WormBaseID: WBGene00001535
• Length: 1152
• Species: Caenorhabditis elegans
• Alignment Length: 1212
• Identity: 363/1212 - (29%)
• Similarity: 557/1212 - (45%)
• Gaps: 235/1212 - (19%)

  Fly    28 NDITWDDLNKDISLDSTTSLAGLNASDAGLEQRMYERSRESKSTQLSRYTEVGEMGSTMRVYN-V 91
            |:||   .:|.:|  ..|:...|:.|.|||    |:.....:.|       :|.:|:...:.| |
 Worm    36 NEIT---TSKGVS--PNTNPLFLSNSTAGL----YDSKGRIRLT-------IGHIGAIGALRNDV 84

  Fly    92 GVLMASH--------LDSPFDLERCGPAVDLALDEINKVFLKPHNITLLKKKGSYPSCSGARAPG 148
            .:|..||        ||...|:|                        ::.:.|...|..|.   .
 Worm    85 KILEVSHKALQAEGILDDDLDVE------------------------IISQTGCGESYEGV---A 122

  Fly   149 LAADMYFQDDVIAFIGPACAFALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTSGILGRIHKW 213
            :|||||....|.|||||.|...::.|||:||:||.|||           |.:..::.:
 Worm   123 VAADMYHLQKVKAFIGPYCNAEMDAVARMAAFWNIPII-----------GYMAASNNL------- 169

  Fly   214 KNENTGMFKDKSKYPTLTRMSYCQCRLIL-VFASVIRQFNWNHVALLVDRSELFSWTVGKNLEYG 277
                    .||:.||||.|:|......|. ...:::|.:.||.||::.: :.:.::....:.|..
 Worm   170 --------ADKNAYPTLARISLRTTNSIAEATCAMLRHYGWNKVAIITN-TGILAYDRVLSFEEV 225

  Fly   278 LRQEGLLSFVK-----ELNGNEEEVYENYLKDASMYARVVI--LSVRGVLVRKFMLAAHSLGMTN 335
            ..|.| ::.||     |...::..:....|.|....||:|:  .|......|:|:.||::.||..
 Worm   226 FHQRG-INVVKKIMFDEFADSKAMIASGLLNDIKNSARIVVCLFSNTRESSREFLTAANTQGMNV 289

  Fly   336 GEWVFLDVEIFQSEYWGDKGWEMKDEHDAKARKAYEALLRVSLLQPTSPKFQD--FADNVR--EN 396
            .|:.:    :|.        |......||......:.    |:||....::.:  ..|:|.  :|
 Worm   290 NEYGY----VFP--------WLQDGGKDASPWTGADG----SMLQKVKDQYANAIIIDDVNSFDN 338

  Fly   397 ALY--------DYNYTFGEGEEVNFFIGAFY--DGVYLLGMALNETLTEGGDIRDGVNITRRMWN 451
            .:.        |...|..:.:..|.: |..|  |.:.|..:|..:.|.|.|...:.:| .|.||.
 Worm   339 TIVGPFIERIKDVGLTEADVDIANIY-GYLYLFDALKLYAIAARKVLNETGKAENLLN-GRMMWQ 401

  Fly   452 R----TFEGI-------TGHVRIDDNGDRDADY----------SILD--------LDPINGKFSV 487
            .    .|.|:       :|.|.:||..:|...|          |:|.        ||..:|
 Worm   402 NMRKLKFVGMVGASGIASGQVSMDDRAERAPLYRGFFVSPNSDSVLPMVHMEPTMLDNCDG---- 462

  Fly   488 VAHYSGVHKVYSAVHGKKIHWPGGREEPPPDVPPCGFLGNSTDCVGNFSTIMYSVFGLLLFLGLV 552
            :|:.||.:::. .....:..||....:.|.|.|.||:.....|    ::.|:.....:|||  :|
 Worm   463 IANKSGCYEIV-VTDIMRDFWPSVDRKMPKDEPDCGYRNERCD----YTLIIIGAALILLF--IV 520

  Fly   553 FLVICLLQKQMKLSKELNNMSWRVRPDDVLIEMGGMFGSKGGLQRLDVENI-SLQQFGIHSGRAS 616
            ..|.....:::...:.|:.:.:|:..||              ||.:|.|.: |:...|....:.|
 Worm   521 AAVSAFFAQKILEKRALDKLPFRIYRDD--------------LQFIDEEQLKSMLSLGSTRTKMS 571

  Fly   617 IASFTSLPPQVY-TTIGQFKGERVAIKKVNVKKVDLTPQLLWEIKQARDVSHENTVRFVGACIDL 680
            ..::.|....:. |.......:.|..:.:...:.|.|  |:..:|.|   .|:|...|:|...:
 Worm   572 NMNYGSRNHAIVGTNTHAIYHKYVQRRPIVFNRADKT--LIQLMKAA---VHDNINPFLGMVWN- 630

  Fly   681 PRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLI 745
            .|..:|::.::||||:|:|::.||:|:||..|..:.|.||:.|:.|||.|.:..||.|...:|||
 Worm   631 EREEMLLVWKFCSRGTLQDIIYNESIQLDTKFHGAFIRDILAGLEYLHASQIGYHGSLTPWSCLI 695

  Fly   746 DGRFVLKISDFGL--------------RTLTTPSDFVRDQNYYLKLLWIAPELL----------- 785
            |..:::|::|:|:              |...|..|..........:|:.:||:|
 Worm   696 DRNWMIKLTDYGIADPLERWEKSQSISRDGLTSDDDKSQATQATSILYESPEMLKNREKNRVRRV 760

  Fly   786 ------PLTTIPGCCPATQRGDVYSFGIILEEIVNRGGPYQEARQQMDVHTILH---KVRQCNGF 841
                  ...|      ..|.||||:||:::.||:.|..|:.|...|.::...|.   ||     .
 Worm   761 DQDWMRQTQT------RRQLGDVYAFGLVMYEIIFRALPFPEGTNQSELVEWLRDGSKV-----V 814

  Fly   842 RPLI-RERECPPDLLELMEKCWADNQEERPTFSTIRSNIRTIM--KGFCENLMDDLLNRMEQYAN 903
            :|.| :.:....||..|::.||....|.||:...|:.|:.|.:  ||   :|:|.:...||||||
 Worm   815 KPTIPQNKVLNMDLSALIQDCWNTTPEMRPSLRRIKLNVETYLNIKG---SLVDQMTRMMEQYAN 876

  Fly   904 NLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCA 968
            |||.||.|:|..|....||.:.||.|:||..||.:|..|..|.|:.|:|.|:.|||||||||:|.
 Worm   877 NLEKLVAERTGMLEEANQRADRLLSQLLPAYVANELKLGRPVPPKTFTSSTVLFSDIVGFTEMCQ 941

  Fly   969 RSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRA 1033
            .:||::||..||.::..||:.|...|.||||||||||:||||:||.||.:|..|||.:|||:.:.
 Worm   942 NASPLEVVAVLNGIFDGFDQFIARKDAYKVETIGDAYMVVSGVPEENGHRHINEIASIALDVHKF 1006

  Fly  1034 VSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSAT 1098
            :|.|.:.||.:.|:|.|:|.|:|.|.|.|||...|.|||||||||.||||||..:|||..:|...
 Worm  1007 LSEFIVPHKRDTKVQCRLGFHTGPVAAAVVGLNAPRYCLFGDTVNMASRMESNSEPGKTQISETA 1071

  Fly  1099 K-AILDKFGTFQMEQRGDVELKGKGTVTTYWLNST-SEGEAR 1138
            | .:|.::..:..||||::.:||||...||||..| |||..|
 Worm  1072 KNLLLKEYPDYICEQRGEIPIKGKGLCMTYWLMGTKSEGSGR 1113

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_GC-like	90..501	CDD:380575	109/470 (23%)
		Protein Kinases, catalytic domain	616..885	CDD:473864	82/306 (27%)
		HNOBA	<891..939	CDD:462234	24/47 (51%)
		CYCc	918..1109	CDD:214485	98/191 (51%)
gcy-8	NP_501324.2	PBP1_NPR_GC-like	80..456	CDD:380575	103/448 (23%)
		Protein Kinases, catalytic domain	558..850	CDD:473864	81/308 (26%)
		CYCc	891..1084	CDD:214485	98/192 (51%)