Protein Alignment CG3216 and gcy-28

DIOPT Version :10

• Sequence 1: NP_726013.2
• Gene: CG3216 / 37376
• FlyBaseID: FBgn0034568
• Length: 1161
• Species: Drosophila melanogaster
• Sequence 2: NP_001021600.1
• Gene: gcy-28 / 172051
• WormBaseID: WBGene00020131
• Length: 1276
• Species: Caenorhabditis elegans
• Alignment Length: 1283
• Identity: 459/1283 - (35%)
• Similarity: 659/1283 - (51%)
• Gaps: 291/1283 - (22%)

  Fly    89 YNVGVLMASHLDSPFD-----LERCGPAVDLALDEINKVFLKPH---NIT----------LLKKK 135
            :||.|::... :|.:|     |::..|.:|:|:.|:.|....|.   |:|          ||.::
 Worm    41 FNVIVILPKR-ESTYDNFGMTLQKAMPVIDIAVQEVIKAKKLPPGWINLTYWDSRLYEDILLAER 104

  Fly   136 GSYPSCSGARAPGLAADMYFQDDVIAFIGPACAFALEPVARLAAYWNK--PIITGMGDQPPSSEG 198
                     .|.......|.:..:.|.:|.|..:.|..|.::.|..|.  ||:|
 Worm   105 ---------HATVGVIQAYCEHRLDAILGFADNYGLATVTKVTAGLNGGIPILT----------- 149

  Fly   199 ELTVTSGILGRIHKWKNENTGMFKDKSKYPTLTRM--SYCQCRLILVFASVIRQF---------- 251
                |||:           ..:...|.:||.||||  ||   ||:   |..:.|.
 Worm   150 ----TSGM-----------PSLLNSKKEYPFLTRMQGSY---RLL---ADSMYQLIAYHDEDSVS 193

  Fly   252 ----NWNHVALLV---DRSELFSWTVGKNLE--------------YGLRQ---EGLLSFVKELNG 292
                :.|::.|:.   |:....:..:.::..              |.:::   |...:|.:|...
 Worm   194 KSNSSLNYLNLIFFYHDKRRAVNRVIAQDESQETGATSSHCYFSLYAIKRYFTEKSKTFKREWAL 258

  Fly   293 N------------EEEVYENYLKDASMYARVVILSVRGVLVRKFMLAAHSLGM-TNGEWVFLDVE 344
            |            |.|.::.:|::.|:.:.|:||......||:.|||||.||| |:||:||::::
 Worm   259 NTPQFPFDEDLVIERETFKQWLREISLQSNVIILCASPDTVREIMLAAHDLGMATSGEYVFINID 323

  Fly   345 IFQSEYWGDKGW----EMKDEHDAKARKAYEALLRVSLLQPTSPKFQDFADNVRENALYDYNYT- 404
            :....: .::.|    :..:|.:.||::||.||..:||.:....::::|...|:|.|...||||
 Worm   324 VSTGSH-AEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFELRVKERADQKYNYTN 387

  Fly   405 -FGEGEEVNFFIGAFYDGVYLLGMALNETLTEGGDIRDGVNITRRMWNRTFEGITGHVRIDDNGD 468
             .|:..|:|.||.||||.|.|..:|||||:..|.|.|:|.|||.|||.|||.||||:|.||.|||
 Worm   388 ITGKDYEMNNFISAFYDAVLLYAIALNETIQSGLDPRNGHNITSRMWGRTFVGITGNVSIDHNGD 452

  Fly   469 RDADYSILDLDPINGKFSVVAHYSGVHKVYSAVHGKKIHWPGGREEPPPDVPPCGFLGNSTDCVG 533
            |.:|||:|||||:..:|..||:|||.......|  .::||.||:  ||.|:|.||:  :.:.|.|
 Worm   453 RYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTV--GQLHWVGGK--PPTDLPICGY--DKSKCPG 511

  Fly   534 NFSTIMYSVFG-LLLFLGLVFLVICLLQKQMKLSKELNNMSWRVR-------------------- 577
             :...:|.:.| .||.|.||.|.| ...::.||.:||..|||::|
 Worm   512 -YPLHVYLLMGSFLLILVLVGLFI-FFWRRYKLEQELAAMSWKIRWEELDGEESQKKNEKKKAKK 574

  Fly   578 ----------------------------PDDVLI---------------EMGGMFGSK------- 592
                                        .:|.||               ::..|...|
 Worm   575 RKNHNDYLPESDPLLRSTSRSSVNSDKFDEDSLIPIRFRLRSSSSGTTRKISAMIDRKLSIFTRK 639

  Fly   593 -----------GGLQ--------------------RL-----------------------DVEN- 602
                       |||.                    ||                       |.||
 Worm   640 KSTPPSESQKNGGLTPNSLQKAENGDCSPINEVQFRLPLNDRRVSSPSSEATRKKNSNEEDPENG 704

  Fly   603 ----ISLQ----QFGIHSGRA----SIASFTSLPPQVYTTIGQFKGERVAIKKVNV-----KKVD 650
                :||:    .||:.|.::    |:.:......|:||....|||..|||||:|:     .::|
 Worm   705 AKKSLSLKNRKLSFGMVSFKSGSGGSVETIAQNNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLD 769

  Fly   651 LTPQLLWEIKQARDVSHENTVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMS 715
            |:...|.|:|:.:|:.|::..||.|||||.|.  ..::||||.:|||:|:||||.||||...:.|
 Worm   770 LSRAQLMELKKMKDLQHDHITRFTGACIDFPH--YCVVTEYCPKGSLEDILENEKIELDKLMKYS 832

  Fly   716 LIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGLRTLTTPSDF----VRDQNYYLK 776
            |:||:|||:.:||||::.:||:|:|.||::|.|||||::||||..|....:.    :.:..||.|
 Worm   833 LLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKK 897

  Fly   777 LLWIAPELLPLTTIPGCCPATQRGDVYSFGIILEEIVNRGGPYQEARQQMDVHTILHKVRQ---- 837
            :||.|||||..:..|..  .||:||:|||.|||.|::.|.|.:....:.:..:.|:.:||:
 Worm   898 MLWTAPELLRDSNAPPM--GTQKGDIYSFAIILHEMMFRKGVFALENEDLSPNEIVQRVRKPVSE 960

  Fly   838 -CNGFRPLIRER-ECPPD------LLELMEKCWADNQEERPTFSTIRSNIRTIMK-GFCENLMDD 893
             ....||.:.|. |...|      ||.||..||:::..|||..|::|..:|::.: ....||:|:
 Worm   961 DQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDN 1025

  Fly   894 LLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFS 958
            ||.||||||||||.||||:|::...||::.||||:|:||..:|..|:||..|:.|.:..||||||
 Worm  1026 LLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFS 1090

  Fly   959 DIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREI 1023
            ||||||.|.::|:||.||..|||||..||.::..:.|||||||||||:||||||| ..|.||.:|
 Worm  1091 DIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPE-RRDDHANQI 1154

  Fly  1024 ALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQ 1088
            |.|:|.:|..|.:|.:||:|..::::|||||||||.|||||.|||.||||||||||:|||||.|.
 Worm  1155 AQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGL 1219

  Fly  1089 PGKIHVSSATKAILDKFGTFQMEQRGDVELKGKGTVTTYWLNSTSEGE 1136
            |.|||||..|..||.:...|::|.||.||:||||..|||||....:.|
 Worm  1220 PLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRGYKDVE 1267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_GC-like	90..501	CDD:380575	146/485 (30%)
		Protein Kinases, catalytic domain	616..885	CDD:473864	116/290 (40%)
		HNOBA	<891..939	CDD:462234	28/47 (60%)
		CYCc	918..1109	CDD:214485	113/190 (59%)
gcy-28	NP_001021600.1	Periplasmic_Binding_Protein_type1	43..485	CDD:471960	145/484 (30%)
		PK_GC-A_B	722..1016	CDD:270944	117/297 (39%)
		HNOBA	<1023..1071	CDD:462234	28/47 (60%)
		CYCc	1050..1233	CDD:214485	111/183 (61%)