DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and Gucy2e

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	XP_036012232.1	Gene:	Gucy2e / 14919	MGIID:	105123	Length:	1139	Species:	Mus musculus

Alignment Length:	1141	Identity:	383/1141 - (33%)
Similarity:	542/1141 - (47%)	Gaps:	205/1141 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 VYNVGVLMASHLDSPFDLERCGPAVDLALDEINKVFL----KPHNITLLKKKGSYPSCSGARAPG 148
            |:.||||.....|..|...|...|..||.:.:|:.|.    ....:.||.:....|...||.:..
Mouse    56 VFKVGVLGPWACDPIFARARPDLAARLAANRLNRDFALDGGPRFEVALLPEPCLTPGSLGAVSSA 120

  Fly   149 LAADMYFQDDVIAFIGPACAFALEPVARLA-------AYWNKPIITGMGDQPPSSEGELTVTSGI 206
            |:.       |...:||....|..|...||       ..|..|.....|...|:    :|..:..
Mouse   121 LSR-------VSGLVGPVNPAACRPAELLAQEAGVALVPWGCPGTRAAGTTAPA----VTPAADA 174

  Fly   207 LGRIHKWKNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNWNHVALLVDRSELFSWT-V 270
            |                           |.          ::|.|.|..|||:....:|  |. .
Mouse   175 L---------------------------YV----------LLRAFRWARVALITAPQDL--WVEA 200

  Fly   271 GKNLEYGLRQEGL-LSFVKELN---------------------------------GNEEEVYENY 301
            |:.|...||..|| ::.|..:.                                 |..|....:.
Mouse   201 GRALSTALRARGLPVALVTSMETSDRSGAREALGRIRDGPRVRGKLPSRVRARWVGPAESGQRSE 265

  Fly   302 LKDASMYARVVILSVRGVLV----RKFML-AAHSLGMTNGEWVFLDVEIFQSEYWGDKGWEMKDE 361
            ....|:.:.|||:.:..||:    ::::| ||..|.:|:|..|||..:..  .|....|.|....
Mouse   266 PASVSVRSAVVIMVMHSVLLGGEEQRYLLEAAEELALTDGSLVFLPFDTL--HYALSPGPEALAA 328

  Fly   362 --HDAKARKAYEALLRVSLLQPTSPKFQDFADNVREN--ALYDYNYTFGEGEEVNFFIGAFYDGV 422
              :.::.|:|::|:|.::...|.....||.....:|:  ...|.|.     ::|:...|..||.|
Mouse   329 FVNSSQLRRAHDAVLTLTRRCPPGGSVQDSLRRAQEHQELPLDLNL-----KQVSPLFGTIYDAV 388

  Fly   423 YLLGMALNETLTE-GGDIRDGVNITRRMWNRTFEGITG---------HVRIDDNGDRDADYSILD 477
            :||...:....|. ||....|.::.|::......|..|         .|.:|.:...:..::...
Mouse   389 FLLAGGVKRARTAVGGGWVSGASVARQVREAQVSGFCGVLGRTEEPSFVLLDTDASGEQLFATHL 453

  Fly   478 LDPINGKFSVVAHYSGVHKVYSAVHGKKIHWPGGREEPPPDVPPCGFLGNSTDCVGNFSTIMYSV 542
            |||:.|            .:.||  |..:|:|.|...|.|| |.|.|   ..|.:.|.......|
Mouse   454 LDPVLG------------SLRSA--GTPMHFPRGGPAPGPD-PSCWF---DPDVICNGGVEPGLV 500

  Fly   543 F-GLLLFLGL----VFLVICLLQKQMKLSKELNNMSWRVRPDDVLIEMGGM--FGSKGGLQRLDV 600
            | |.||.:|:    .||...|..:       |.:|.....|:.:::.:..:  ....||..|..|
Mouse   501 FVGFLLVIGMGLTGAFLAHYLRHR-------LLHMQMASGPNKIILTLEDVTFLHPPGGSSRKVV 558

  Fly   601 ENISLQQFGIHSGRA--SIASFTSLP--PQVYTTIGQFKGERVAIKKV-NVKKVDLTPQLLWEIK 660
            :       |..|..|  |.:...|:|  ||..|.:|.::|:.|.:||. ....:.:.|.......
Mouse   559 Q-------GSRSSLATRSASDIRSVPSQPQESTNVGLYEGDWVWLKKFPGEHHMAIRPATKTAFS 616

  Fly   661 QARDVSHENTVRFVGACI----DLP----RPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLI 717
            :.|::.|||...::|..:    |.|    ...:.:::|:|:||||.|:|....|:|||.|:.||:
Mouse   617 KLRELRHENVALYLGLFLAGTADSPATPGEGILAVVSEHCARGSLHDLLAQREIKLDWMFKSSLL 681

  Fly   718 HDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFG-------LRTLTTPSDFVRDQNYYL 775
            .|::|||.|||:..| |||:|:|.||::|||||||::|.|       .|.|..|.. ..||
Mouse   682 LDLIKGMRYLHHRGV-AHGRLKSRNCVVDGRFVLKVTDHGHGRLLEAQRVLPEPPS-AEDQ---- 740

  Fly   776 KLLWIAPELL--PLTTIPGCCPATQRGDVYSFGIILEEIVNRGGPYQEARQQMDVHTILHKVRQ- 837
              ||.|||||  |.....|    |..|||:|..||::|:|.|..||  |..::....::.:||.
Mouse   741 --LWTAPELLRDPSLERRG----TLAGDVFSLAIIMQEVVCRSTPY--AMLELTPEEVIQRVRSP 797

  Fly   838 ---CNGFRPLIRERECPPDLLELMEKCWADNQEERPTFSTIRSNIRTIMKGFCENLMDDLLNRME 899
               |   |||:...:.|.:.::||.:|||::.|.||:........::|.||...|::|.:|..:|
Mouse   798 PPLC---RPLVSMDQAPMECIQLMTQCWAEHPELRPSMDLTFDLFKSINKGRKTNIIDSMLRMLE 859

  Fly   900 QYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFT 964
            ||::|||.|:.|:|.:|..|||:|:.||.|:||..||:.|..|..||||.|..||:|||||||||
Mouse   860 QYSSNLEDLIRERTEELEQEKQKTDRLLTQMLPPSVAEALKMGTSVEPEYFEEVTLYFSDIVGFT 924

  Fly   965 ELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALD 1029
            .:.|.|.|::||:.|||||:.||.|||.:||||||||||||:|.||||:.||.:||.|||.|:||
Mouse   925 TISAMSEPIEVVDLLNDLYTLFDAIIGAHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLD 989

  Fly  1030 ILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHV 1094
            ||.||.||.:||.||..::||||:|||...|||||..||.||||||||||||||||||.|.:|||
Mouse   990 ILSAVGSFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHV 1054

  Fly  1095 SSATKAILDKFGT-FQMEQRGDVELKGKGTVTTYWL 1129
            :.:|..||..... ||||.||..||||||...||||
Mouse  1055 NMSTVRILRALDQGFQMECRGRTELKGKGIEDTYWL 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	97/470 (21%)
		ANF_receptor	107..479	CDD:279440	87/436 (20%)
		PKc_like	616..885	CDD:304357	101/292 (35%)
		TyrKc	627..877	CDD:197581	95/271 (35%)
		HNOBA	<882..939	CDD:285003	27/56 (48%)
		CYCc	918..1109	CDD:214485	120/191 (63%)
		Guanylate_cyc	945..1131	CDD:278633	123/186 (66%)
Gucy2e	XP_036012232.1	PBP1_sensory_GC_DEF-like	58..465	CDD:380594	99/477 (21%)
		PK_GC-2D	570..845	CDD:270945	100/291 (34%)
		HNOBA	<854..899	CDD:400168	22/44 (50%)
		CYCc	879..1070	CDD:214485	120/190 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820