DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and Gucy2d

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_001124165.1	Gene:	Gucy2d / 14918	MGIID:	106030	Length:	1117	Species:	Mus musculus

Alignment Length:	1110	Identity:	392/1110 - (35%)
Similarity:	563/1110 - (50%)	Gaps:	159/1110 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 YNVGVLMASHLDSPFDLERCGP---------AVDLALDEINKVFLKPHNITLLKKKGS------Y 138
            :.:|||      .|:|   |.|         |..||:|::|:      :.:||  .||      .
Mouse    70 FTLGVL------GPWD---CDPIFAQALPSIATQLAVDQVNQ------DASLL--PGSQLDFKVL 117

  Fly   139 PSCSGARAP-GLAADMYFQDDVIAFIGPACAFALEPVARLAAYWNKPIITGMGDQPPSSEGELTV 202
            |  :|...| .||..:..::.|.||:||.........|.||..|.|.:.: ...:.|...|:|.
Mouse   118 P--TGCDTPHALATFVAHKNIVAAFVGPVNPGFCSAAALLAQGWGKSLFS-WACEAPEGGGDLV- 178

  Fly   203 TSGILGRIHKWKNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNWNHVALLVDRSELFS 267
                                     |||...:.       |..||:|.|.|...|::....::
Mouse   179 -------------------------PTLPSAAD-------VLLSVMRHFGWARWAIVSSHQDI-- 209

  Fly   268 W-TVGKNLEYGLRQEGL-LSFVKELNGNEEEVYENYLKDASMYA-RVVILSVRGVLV-----RKF 324
            | |..:.|....|..|| :..|..|...|:...|...:..|::. ::|:|.:...|:     ...
Mouse   210 WVTTAQQLATAFRTHGLPIGLVTSLGPGEKGATEVCKQLHSVHGLKIVVLCMHSALLGGLEQTTL 274

  Fly   325 MLAAHSLGMTNGEWVFL--DVEIFQSEYWGDKGWEMKDEHDAKARKAYEALLRVSLLQPTSPKFQ 387
            :..|...|:|:|..|||  |..:|...| |::.:.:.|:| ...::||:|:|.|||  .:||:..
Mouse   275 LHCAWEEGLTDGRLVFLPYDTLLFALPY-GNRSYLVLDDH-GPLQEAYDAVLTVSL--ESSPESH 335

  Fly   388 DF-ADNVRENALYDYNYTFGEGEEVNFFIGAFYDGVYLLGMALNETLTEGGDIRDGVNITRRMWN 451
            .| |..:...|..:.     |.|:|:...|..||.|.||..|||.:.|.|..: .|.::...:..
Mouse   336 AFTATEMSGGATANL-----EPEQVSPLFGTIYDAVILLAHALNRSETHGAGL-SGAHLGDHVRA 394

  Fly   452 RTFEGITGHVRIDDNGDRDADYSILDLDPINGKFSVVAHYSGVHKVYSAVHGKKIHWPGGREEPP 516
            ....|.:..:|.|..|.|.|.|.|||.|. .|...|..|............||.||:|||  .||
Mouse   395 LDVAGFSQRIRTDGKGRRLAQYVILDTDG-EGSQLVPTHILDTSTWQVQPLGKPIHFPGG--SPP 456

  Fly   517 PDVPPCGFLGNSTDCV------GNFSTIMYSVFGLLLFLGLVFLVICLLQKQMKL---------- 565
            .....|.|..| |.|:      |:..|:..:.. |.|..|.:...|.|..:|::|
Mouse   457 AHDASCWFDPN-TLCIRGVQPLGSLLTLTIACV-LALVGGFLAYFIRLGLQQLRLLRGPHRILLT 519

  Fly   566 SKELNNMS---WRVRPDDVLIEMGGMFGS--KGGLQRLDVENISLQQFGIHSGRASIASFTSLPP 625
            |:||..:.   .|.||.   ::.|....|  .||..|      |:.|          .|..|||.
Mouse   520 SQELTFLQRTPSRRRPH---VDSGSESRSVVDGGSPR------SVTQ----------GSARSLPA 565

  Fly   626 QV-YTTIGQFKGERVAIKKVNVKKV-DLTPQLLWEIKQARDVSHENTVRFVGACIDLPRPTVLIL 688
            .: :|.:..::||.|.:||...... ||.|..|..:::.|::.|||...|:|..:. |..:.::|
Mouse   566 FLEHTNVALYQGEWVWLKKFEAGVAPDLRPSSLSFLRKLREMRHENVTAFLGLFVG-PGVSAMVL 629

  Fly   689 TEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKI 753
             |:|:||||:|:|:||.:.|||.|:.||:.|:::|:.|||:... .||:|:|.||::|.||||||
Mouse   630 -EHCARGSLEDLLQNENLRLDWTFKASLLLDLIRGLRYLHHRRF-PHGRLKSRNCVVDTRFVLKI 692

  Fly   754 SDFGLRTLTTPSDFVRDQNYYLKLLWIAPELLPLTTIPGCCPATQRGDVYSFGIILEEIVNRGGP 818
            :|.|...........|.|....:|||.|||||   ..||  .||.:|||:|..|||:|::.|..|
Mouse   693 TDHGYAEFLESHCSSRPQPAPEELLWTAPELL---RGPG--KATFKGDVFSLAIILQEVLTRDPP 752

  Fly   819 YQEARQQMDVHTILHKVRQ----CNGFRPLIRERECPPDLLELMEKCWADNQEERPTFSTIRSNI 879
            |  ....:....|:.||..    |   |||:...:.|.:.::||:.||.:..::||:...|.:..
Mouse   753 Y--CSWGLSAEEIIRKVASPPPLC---RPLVSPDQGPLECIQLMQLCWEEAPDDRPSLDQIYTQF 812

  Fly   880 RTIMKGFCENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDL 944
            ::|.:|...:::|.:|..:|:|:.:||.||:|:|.:|.||:::||.||.|:||..||..|..|..
Mouse   813 KSINQGKKTSVVDSMLRMLEKYSESLEDLVQERTEELELERRKTERLLSQMLPPSVAHALKMGTT 877

  Fly   945 VEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVS 1009
            ||||.|..||||||||||||.:.|.|.|::||.||||||:.||.::..:||||||||||||:|.|
Mouse   878 VEPEYFDQVTIYFSDIVGFTTISALSEPIEVVGFLNDLYTLFDAVLDSHDVYKVETIGDAYMVAS 942

  Fly  1010 GLPEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFG 1074
            |||..||::||.|||.:|||||....:|.:||.|:..|::|.|:|||...|||||..||.|||||
Mouse   943 GLPRRNGNRHAAEIANLALDILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFG 1007

  Fly  1075 DTVNTASRMESTGQPGKIHVSSAT-KAILDKFGTFQMEQRGDVELKGKGTVTTYWLNSTSEGEAR 1138
            |||||||||||||.|.:||||.:| :|:|.....::::.||..||||||...||||.. ..|..|
Mouse  1008 DTVNTASRMESTGLPYRIHVSQSTVQALLSLDEGYKIDVRGQTELKGKGLEETYWLTG-KVGFCR 1071

  Fly  1139 P-PTP 1142
            | |||
Mouse  1072 PLPTP 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	112/432 (26%)
		ANF_receptor	107..479	CDD:279440	103/398 (26%)
		PKc_like	616..885	CDD:304357	99/274 (36%)
		TyrKc	627..877	CDD:197581	94/255 (37%)
		HNOBA	<882..939	CDD:285003	24/56 (43%)
		CYCc	918..1109	CDD:214485	115/191 (60%)
		Guanylate_cyc	945..1131	CDD:278633	114/186 (61%)
Gucy2d	NP_001124165.1	PBP1_sensory_GC_DEF-like	71..445	CDD:380594	112/439 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..557		9/36 (25%)
		PK_GC-2D	554..818	CDD:270945	101/286 (35%)
		CYCc	855..1044	CDD:214485	113/188 (60%)
		Interaction with NCALD. /evidence=ECO:0000250\|UniProtKB:P51839	874..915		26/40 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1096..1117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920