DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and Gucy2c

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_001120790.1	Gene:	Gucy2c / 14917	MGIID:	106903	Length:	1072	Species:	Mus musculus

Alignment Length:	1131	Identity:	350/1131 - (30%)
Similarity:	523/1131 - (46%)	Gaps:	230/1131 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 YNVGVLMASHLDSPFDLERCGPAVDLALDEINKVFLKPH-NIT----------LLKKKGSYPSCS 142
            |.:.|||..:......::....||:..||.:.|...:.. |:|          |:.|.|   .|.
Mouse    35 YEISVLMMDNSAYKEPMQNLREAVEEGLDIVRKRLREADLNVTVNATFIYSDGLIHKSG---DCR 96

  Fly   143 GARAPGLAADMYFQDDVI-----------AFIGPACAFALEPVARLAAYWNKPIITGMGDQPPSS 196
            .:...||        |::           |.:||:|.::...: .|....|.|:|:. |....|.
Mouse    97 SSTCEGL--------DLLREITRDHKMGCALMGPSCTYSTFQM-YLDTELNYPMISA-GSYGLSC 151

  Fly   197 EGELTVTSGILGRIHK--------WKNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNW 253
            :.:.|:|. ||....|        ||..|..                            .:.|:|
Mouse   152 DYKETLTR-ILPPARKLMYFLVDFWKVNNAS----------------------------FKPFSW 187

  Fly   254 NHVALLVDRSE---LFSWTVGKNLEYGLRQ-EGLLSFVKELNGNEEEVYENYLKDASMYARVVIL 314
            |...:..:.||   .| |.:.. ||.|:.. ..:|:|...|..:|:  ::..|...:..:.|:::
Mouse   188 NSSYVYKNGSEPEDCF-WYLNA-LEAGVSYFSEVLNFKDVLRRSEQ--FQEILTGHNRKSNVIVM 248

  Fly   315 --------SVRGVLVRKFMLAAHSLGMTNGEWVFLDVEIFQSEYWGDKGWEMKDEHDAKARKAYE 371
                    .|:|.|            ....:.|.:.|::|.:.|:         |.:..|.:..:
Mouse   249 CGTPESFYDVKGDL------------QVAEDTVVILVDLFSNHYF---------EENTTAPEYMD 292

  Fly   372 ALLRVSLLQPTSPKFQDFADNVRENALYDYNYTFGEGEEVNFFIGAFYDGVYLLGMALNETLTEG 436
            .:|.::|....|......|:.            |..|.  :.|..|:.:|..|.|..| :|..|.
Mouse   293 NVLVLTLPSEQSTSNTSVAER------------FSSGR--SDFSLAYLEGTLLFGHML-QTFLEN 342

  Fly   437 GDIRDGVNITRRMWNRTFEGITGHVRIDDNGDRDADYSILDLDPINGKFSVVAHY-SGVHKVYSA 500
            |:...|....|...|.||:|..|.|.:||:||.|...|:|.:.....|:.|:..| :..:|....
Mouse   343 GENVTGPKFARAFRNLTFQGFAGPVTLDDSGDIDNIMSLLYVSLDTRKYKVLMKYDTHKNKTIPV 407

  Fly   501 VHGKKIHWPGGREEPPPDVPPCGFLGNSTDCVGNFSTIMYSVFGLLLFLGLVFLVICLLQKQMKL 565
            .......|.  ..:.|.|||..|           ...:|.:||.|...|.::.|:..|:.::.:.
Mouse   408 AENPNFIWK--NHKLPNDVPGLG-----------PQILMIAVFTLTGILVVLLLIALLVLRKYRR 459

  Fly   566 SKELNNMSWRVRPDDVLIEMGGMFGSKGGLQRLDVENISLQQFGIHSGRASIASFTSLPPQVYTT 630
            ...|....|...|.:.:..          |:..:..:|||:   |...|
Mouse   460 DHALRQKKWSHIPSENIFP----------LETNETNHISLK---IDDDR---------------- 495

  Fly   631 IGQFKGERVAIKKVNVKKVDLTPQLLWEI---------KQARDVS------HENTVRFVGAC-ID 679
                  .|..|::|...|.|....:|.::         ||..|::      :.|..:|.|.. :|
Mouse   496 ------RRDTIQRVRQCKYDKKKVILKDLKHSDGNFSEKQKIDLNKLLQSDYYNLTKFYGTVKLD 554

  Fly   680 LPRPTVLILTEYCSRGSLKDVLENEAIE------LDWNFRMSLIHDIVKGMNYLHNSDVAAHGKL 738
               ..:..:.|||.||||::|| |:.|.      :||.|::|:::||.|||:|||:|.:..||:|
Mouse   555 ---TRIFGVVEYCERGSLREVL-NDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRL 615

  Fly   739 RSCNCLIDGRFVLKISDFGLRTLTTPSDFVRDQNYYLKLLWIAPELLPLTTIPGCCPATQRGDVY 803
            :|.||::|.|.|:||:|||..::..|.          |.||.|||.|...||      :|:||||
Mouse   616 KSTNCVVDSRMVVKITDFGCNSILPPK----------KDLWTAPEHLRQATI------SQKGDVY 664

  Fly   804 SFGIILEEIVNRGGPYQEARQQMDVHTILHKVRQCNG--FRP-----LIRERECPPDLLELMEKC 861
            ||.||.:||:.|...:.....: |.:..:.:|....|  |||     ...|:|.  ::..|::.|
Mouse   665 SFAIIAQEIILRKETFYTLSCR-DHNEKIFRVENSYGKPFRPDLFLETADEKEL--EVYLLVKSC 726

  Fly   862 WADNQEERPTFSTIRSNIRTIMKGF----CENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQR 922
            |.::.|:||.|..|.|.:..|...|    .|:.||.|:.|::.|:.|||.||||:|:....|:.|
Mouse   727 WEEDPEKRPDFKKIESTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDR 791

  Fly   923 TEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFD 987
            .:.|.:.:|||.|.:.|....:||||.:..||||||||||||.:|..|:||:||:.|||:|.:||
Mouse   792 ADHLNFMLLPRLVVKSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFD 856

  Fly   988 RIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIG 1052
            :|:..:||||||||||||:|.||||..||::||.:|:.||||||..:.:|.|.|.|...:.||||
Mouse   857 QIVDHHDVYKVETIGDAYVVASGLPMRNGNRHAVDISKMALDILSFIGTFELEHLPGLPVWIRIG 921

  Fly  1053 MHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFG-TFQMEQRGDV 1116
            :|||...|||||.|||.||||||||||||||||||.|.:||:||:|..||.:.. .|..|.||:.
Mouse   922 VHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTITILKRTDCQFLYEVRGET 986

  Fly  1117 ELKGKGTVTTYWLNSTSEGEARPPTP 1142
            .|||:||.|||||....:.|...|:|
Mouse   987 YLKGRGTETTYWLTGMKDQEYNLPSP 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	93/448 (21%)
		ANF_receptor	107..479	CDD:279440	87/413 (21%)
		PKc_like	616..885	CDD:304357	91/297 (31%)
		TyrKc	627..877	CDD:197581	89/278 (32%)
		HNOBA	<882..939	CDD:285003	23/60 (38%)
		CYCc	918..1109	CDD:214485	110/191 (58%)
		Guanylate_cyc	945..1131	CDD:278633	116/186 (62%)
Gucy2c	NP_001120790.1	Periplasmic_Binding_Protein_Type_1	35..415	CDD:299141	95/461 (21%)
		PKc_like	480..749	CDD:304357	96/316 (30%)
		STYKc	502..744	CDD:214568	88/264 (33%)
		CYCc	787..978	CDD:214485	110/190 (58%)
		Guanylate_cyc	814..1001	CDD:278633	116/186 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820