Protein Alignment CG3216 and gucy2d

DIOPT Version :10

• Sequence 1: NP_726013.2
• Gene: CG3216 / 37376
• FlyBaseID: FBgn0034568
• Length: 1161
• Species: Drosophila melanogaster
• Sequence 2: XP_005165318.1
• Gene: gucy2d / 140426
• ZFINID: ZDB-GENE-011128-9
• Length: 1141
• Species: Danio rerio
• Alignment Length: 1265
• Identity: 399/1265 - (31%)
• Similarity: 612/1265 - (48%)
• Gaps: 265/1265 - (20%)

  Fly     9 HFFFLMYVNCFSAHPNPRRNDITWDDLNKDISLDSTTSLAGLNASDAGLEQRMYERSRESKSTQL 73
            |..||    |.|.||.       |          .|.|.||             :|.|:..|:|.
Zfish     4 HTSFL----CQSHHPR-------W----------QTQSSAG-------------KRRRKQSSSQK 34

  Fly    74 SRYTEVGEMGST--MRVYN-------VGVLMASHL-----DSPFDLERCGP-------------- 110
            |. |....:.|:  :|.::       :.::|.|:.     .:.|.:...||
Zfish    35 SE-TPASPVSSSPVLRSHSWWGNCFLLPLVMLSYFPCEAWGTTFKIAIVGPWACDPMYSKALPDL 98

  Fly   111 AVDLALDEINKVFLKP-------HNITLLKKKGSYPSCSGARAPGLAADMYFQDDVIAFIGPACA 168
            |..||:..|||   .|       ::.|::.:     .||.:|  |||.....:....||:|||..
Zfish    99 AARLAMSRINK---DPELNKGYWYDYTVINE-----DCSSSR--GLARFAELEGYGSAFLGPANP 153

  Fly   169 FALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTSGILGRIHKWKNENTGMFK---DKSKYPTL 230
            ........||..|||.|::                         |     |..|   |:..|||.
Zfish   154 GYCTAATLLAKNWNKGILS-------------------------W-----GCLKAEMDEEMYPTF 188

  Fly   231 TRMSYCQCRLILVFASVIRQFNWNHVALLVDRSELFSWTVGKNLEYGLRQEGL-----LSFVKEL 290
            .|......|::.   ||:|.|.|.||.::....:::..| |..|...||..||     ::..::.
Zfish   189 LRPLPLSSRVLF---SVLRFFRWAHVGIVTAEGDMWEAT-GHELAASLRALGLPVGKVVTMEQDK 249

  Fly   291 NGNEEEVYENYLKDASMYARVVILSVRGVLV-----RKFMLAAHSLGMTNGEWVFL--DVEIFQS 348
            .|..:.:  ..::|... .||||:.:...|:     .:.:..|..:.|.:..::|:  |..::..
Zfish   250 EGPRQAL--QAIRDTDR-VRVVIMCMHSALIGGEEQYQLLTTALEMRMIDRGYIFIPYDTLLYSL 311

  Fly   349 EYWGDKGWEMKDEHDAKARKAYEALLRVSLLQPTSPKFQDFADNVRENALYDYNYTFGEGEE--- 410
            .|...|...:  .:|:|.|:||:.:|.|::.|.....::.|  |..:.:......|  ..||
Zfish   312 PYENVKYPIL--ANDSKLRRAYDGVLTVTMDQGEQNFYEAF--NAAQESFEIRGST--SAEEVTR 370

  Fly   411 -VNFFIGAFYDGVYLLGMALNET-LTEGGDIRDGVNITRRMWNRTFEGITGHVRIDDNGD-RDAD 472
             |:.|.|..|:.:|...||..:: .:.||....|..:::......|:|....:....||: ....
Zfish   371 WVSPFFGTIYNMIYYTAMAAEQSRASSGGRWVSGDLLSQNEGGFEFDGFNQRISGGTNGEGMQVR 435

  Fly   473 YSILDLDPINGKFSVVAH----------YSGVHKVYSAVHGKKIHWPGGREEPPPDVPPCGFLGN 527
            |::||.|. :|......|          |.|:..:     ||.||:.|.  .|..|. .|.| ..
Zfish   436 YAVLDSDG-SGSSLYRTHALEASHTYGKYGGLKYL-----GKSIHFAGA--SPSSDA-NCWF-SP 490

  Fly   528 STDCVGNFSTIMYSVFGLLLFL-------GLVFLVICLLQKQMKLSKELNNMSWRVRPDDVLIEM 585
            ...|.|....:  ::|.||:|.       |::||                    :||.    ...
Zfish   491 YIACSGGLDGV--TLFFLLMFFIVLIAGAGILFL--------------------QVRK----YGA 529

  Fly   586 GGMFGS---KGG--------------------LQRLDVENISLQQFGIHSGRASIA--SFTSLPP 625
            ||.||:   .||                    .::|:.|::...|..:.:.|.|::  |:.:..|
Zfish   530 GGFFGAFIGGGGSPTKIVLTLDDLVFINTTLSRRKLNDESMLKSQLDVKTPRHSVSGRSYITSTP 594

  Fly   626 QVYTTIGQFKGERVAIKKV----NVKKVDLTPQLLWEIKQARDVSHENTVRFVGACIDLPRPTVL 686
            :. :.:..|:|:.|.:||.    ::.::..:.|.::  .:.||:.|||...|:|..:|    |.:
Zfish   595 ET-SNVAVFEGDWVWLKKCPCADSITEISESTQTIF--VKLRDMRHENLNLFLGLFMD----TGI 652

  Fly   687 --ILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRF 749
              |:||:|:||||:|:|.||.:.|||.|:.||:.|:::||.||||..: .||:|:|.||::||||
Zfish   653 FGIVTEHCTRGSLEDLLNNEEMRLDWMFKSSLLLDLIRGMKYLHNRGI-IHGRLKSRNCVVDGRF 716

  Fly   750 VLKISDFGLRTLTTPSDFVRDQNYYLKLLWIAPELL--PLTTIPGCCPATQRGDVYSFGIILEEI 812
            |||::|:|...:....:.:.:.|......|.|||:|  |.....|..|    ||||||.||::|:
Zfish   717 VLKVTDYGFNEILNCQNIILEDNAPEDQFWTAPEILRNPDLKKKGTYP----GDVYSFSIIMQEV 777

  Fly   813 VNRGGPYQEARQQMDVHTILHKVRQ----CNGFRPLIRERECPPDLLELMEKCWADNQEERPTFS 873
            ::|..|:  ....|....|:.|||.    |   ||.:...|.|.|:::||::.|::..|:||||.
Zfish   778 ISRCAPF--CMLDMPPEEIIEKVRSPPPLC---RPTVSMDEAPLDVIQLMKQAWSEEPEQRPTFE 837

  Fly   874 TIRSNIRTIMKGFCENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQ 938
            .|....:::.||...|::|.:|..:|||::|||.|:.|:|.:|.:|:|:|:.||.|:||:.||..
Zfish   838 DIFRQFKSMNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEVERQKTDALLAQMLPKSVALA 902

  Fly   939 LMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGD 1003
            |..|..|:||.|:.||:|||||||||.:.|.|.|::||:.|||||:.||.||..:||||||||||
Zfish   903 LKTGKPVKPEHFAEVTLYFSDIVGFTTISALSEPIEVVDLLNDLYTHFDGIIAIHDVYKVETIGD 967

  Fly  1004 AYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMP 1068
            ||:|.||:|..||.:||.|:|.|:||||..:.:|.:||.|:.|::||||:|||.|.|||||.|||
Zfish   968 AYMVASGVPNRNGTRHAAEMANMSLDILHCIGTFKMRHMPDVKVKIRIGLHSGPVVAGVVGLKMP 1032

  Fly  1069 HYCLFGDTVNTASRMESTGQPGKIHVSSATKAILD--KFGTFQMEQRGDVELKGKGTVTTYWLNS 1131
            .||||||||||||||||||.|.:|||:.:|..:|:  |.| ::::.||..||||||...|:||..
Zfish  1033 RYCLFGDTVNTASRMESTGLPYRIHVNQSTVDVLNSLKLG-YKIDTRGRTELKGKGVEETFWLVG 1096

  Fly  1132 TSEGEARP-PTPQILT---------TDEVP 1151
             .:|..:| |.|..||         .||:|
Zfish  1097 -RDGFDKPLPIPPDLTPGASNHGISLDEIP 1125

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_GC-like	90..501	CDD:380575	101/474 (21%)
		Protein Kinases, catalytic domain	616..885	CDD:473864	98/282 (35%)
		HNOBA	<891..939	CDD:462234	22/47 (47%)
		CYCc	918..1109	CDD:214485	115/192 (60%)
gucy2d	XP_005165318.1	PBP1_sensory_GC_DEF-like	78..470	CDD:380594	98/450 (22%)
		PK_GC-2D	581..849	CDD:270945	99/284 (35%)
		HNOBA	<858..903	CDD:462234	21/44 (48%)
		CYCc	883..1075	CDD:214485	115/192 (60%)