DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG3216 and LRRK2

DIOPT Version :9

Sequence 1:NP_726013.2 Gene:CG3216 / 37376 FlyBaseID:FBgn0034568 Length:1161 Species:Drosophila melanogaster
Sequence 2:NP_940980.4 Gene:LRRK2 / 120892 HGNCID:18618 Length:2527 Species:Homo sapiens


Alignment Length:472 Identity:107/472 - (22%)
Similarity:177/472 - (37%) Gaps:160/472 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   519 VPPCG----FLGNSTDCVGNFSTIMYSVFGLLLFLGLVFLVIC---------------------- 557
            ||.|.    .||...|   :..::|..     .|.||:.:.||                      
Human  1767 VPSCRKGCILLGQVVD---HIDSLMEE-----WFPGLLEIDICGEGETLLKKWALYSFNDGEEHQ 1823

  Fly   558 --LLQKQMKLSKE-----------LNNMSWRVRPDDVLIEMGGMFGSKGGLQRLDVENISLQ--- 606
              ||...||.::|           |.....::.||.:|.::.         :.:.:.|..|:   
Human  1824 KILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLP---------RNIMLNNDELEFEQ 1879

  Fly   607 --QFGIHSGRASIASFTSLPPQVYTTIGQFKGERVAIKKVNVKKVDLTPQLLWEIKQARDVSHEN 669
              :|.:..|     ||.|    ||.  ..::||.||:|..| |...|. .|..|:.....:.|.:
Human  1880 APEFLLGDG-----SFGS----VYR--AAYEGEEVAVKIFN-KHTSLR-LLRQELVVLCHLHHPS 1931

  Fly   670 TVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAA 734
            .:..:.|.|   ||.:|:: |..|:|||..:|:.:...|....:..:...:..|:.||| |.:..
Human  1932 LISLLAAGI---RPRMLVM-ELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLH-SAMII 1991

  Fly   735 HGKLRSCNCLI-----DGRFVLKISDFGLRTLT----------TPSDFVRDQNYYLKLLWIAPEL 784
            :..|:..|.|:     :...:.||:|:|:....          ||.             :.|||:
Human  1992 YRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPG-------------FRAPEV 2043

  Fly   785 LPLTTIPGCCPATQRGDVYSFGIILEEIVNRGGPYQEARQQMDVHTILHKVRQCNGFRPL----- 844
            .....|     ..|:.||||||::|.:|:..||            .|:..::..|.|..|     
Human  2044 ARGNVI-----YNQQADVYSFGLLLYDILTTGG------------RIVEGLKFPNEFDELEIQGK 2091

  Fly   845 ----IRERECPP-DLLE-LMEKCWADNQEERPTFSTIRSNIRTIMKGFCENLMDDLLNRMEQYAN 903
                ::|..|.| .::| |:::|..:|.:||||.:.:                .|:||..|    
Human  2092 LPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQV----------------FDILNSAE---- 2136

  Fly   904 NLESLVEEKTRQLSLEK 920
             |..|    ||::.|.|
Human  2137 -LVCL----TRRILLPK 2148

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG3216NP_726013.2 PBP1_NPR_like 90..496 CDD:107368
ANF_receptor 107..479 CDD:279440
PKc_like 616..885 CDD:304357 72/294 (24%)
TyrKc 627..877 CDD:197581 69/275 (25%)
HNOBA <882..939 CDD:285003 10/39 (26%)
CYCc 918..1109 CDD:214485 2/3 (67%)
Guanylate_cyc 945..1131 CDD:278633
LRRK2NP_940980.4 Required for RAB29-mediated activation. /evidence=ECO:0000269|PubMed:29212815 1..969
LRR 1 983..1004
leucine-rich repeat 985..1012 CDD:275380
LRR 1012..>1286 CDD:227223
LRR 2 1012..1033
leucine-rich repeat 1013..1036 CDD:275380
LRR 3 1036..1057
leucine-rich repeat 1037..1084 CDD:275380
LRR 4 1059..1080
LRR 5 1084..1105
leucine-rich repeat 1085..1108 CDD:275380
LRR 6 1108..1129
leucine-rich repeat 1109..1130 CDD:275380
LRR 7 1130..1150
leucine-rich repeat 1131..1174 CDD:275380
LRR 8 1174..1196
leucine-rich repeat 1175..1197 CDD:275380
LRR 9 1197..1218
leucine-rich repeat 1198..1221 CDD:275380
LRR 10 1221..1241
leucine-rich repeat 1222..1246 CDD:275380
LRR 11 1246..1267
leucine-rich repeat 1247..1269 CDD:275380
LRR 12 1269..1291
RocCOR 1334..1507 CDD:206741
COR 1527..1740 CDD:318343
STKc_LRRK2 1884..2135 CDD:270970 76/314 (24%)
WD 1 2139..2183 5/14 (36%)
WD 2 2188..2228
WD 3 2233..2276
WD 4 2281..2327
WD 5 2333..2377
WD 6 2402..2438
WD 7 2443..2497
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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