Protein Alignment CG3216 and Npr2

DIOPT Version :10

• Sequence 1: NP_726013.2
• Gene: CG3216 / 37376
• FlyBaseID: FBgn0034568
• Length: 1161
• Species: Drosophila melanogaster
• Sequence 2: NP_446290.1
• Gene: Npr2 / 116564
• RGDID: 620851
• Length: 1047
• Species: Rattus norvegicus
• Alignment Length: 1118
• Identity: 452/1118 - (40%)
• Similarity: 621/1118 - (55%)
• Gaps: 160/1118 - (14%)

  Fly    87 RVYNVGVLMASH-LDSPFDLERCGPAVDLALDEINKVFLKPHNITLLKKK--GSYPSCSGARAPG 148
            |...:.|::..| |...:...|.||||.||::.:.:..  |.::..:..:  |   :||...||.
  Rat    23 RNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRAL--PVDLRFVSSELDG---ACSEYLAPL 82

  Fly   149 LAADMYFQDDVIAFIGPACAFALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTSGILGRIHKW 213
            .|.|:....|....:||.|.:....|||.|::|:.|::|..           .|.||...
  Rat    83 RAVDLKLYHDPDLLLGPGCVYPAASVARFASHWHLPLLTAG-----------AVASGFAA----- 131

  Fly   214 KNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNWNHVALLV-------DRSELFSWTV- 270
            |||:         |.||.|......:|.....::...|||...|.|:       ||...|  |:
  Rat   132 KNEH---------YRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHYF--TIE 185

  Fly   271 -------GKNLEYGLRQEGLLSFVKELNGNEEEVYENYLKDASMYARVVILSVRGVLVRKFMLAA 328
                   |.||..   |..:  :.:|..|.|:..:  :::   ...|:|.:.....::.:.:|.|
  Rat   186 GVFEALQGSNLSV---QHQV--YTREPGGPEQATH--FIR---ANGRIVYICGPLEMLHEILLQA 240

  Fly   329 HSLGMTNGEWVFLDVEIFQSEY-----------WGDKGWEMKDEHDAKA-RKAYEALLRVSLLQP 381
            ....:|||::||..:::|....           |.|.    :.:..|:| |:|::.:|.::..:|
  Rat   241 QRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDN----RTQEQAQALREAFQTVLVITYREP 301

  Fly   382 TSPKFQDFADNVRENALYDYNYTFGEGEE-----VNFFIGAFYDGVYLLGMALNETLTEGGDIRD 441
            .:|::|:|.:.:...|..|:      |.|     :|...|.||||:.|....||||:.|||...|
  Rat   302 PNPEYQEFQNRLLIRAREDF------GVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTRED 360

  Fly   442 GVNITRRMWNRTFEGITGHVRIDDNGDRDADY---SILDLDPINGKFSVVAHYSGVHK-VYSAVH 502
            |:.|..:|..|.:.|:||.|.:|.|.||:.|:   ::.||:  :|.|...|||||..| ::..
  Rat   361 GLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLE--SGDFQPAAHYSGAEKQIWWT-- 421

  Fly   503 GKKIHWPGGREEPPPDVPPCGFLGNSTDCVGN-FSTIMYSVFGLLLFLGLVFLVI----CLLQKQ 562
            |:.|.|..|  .||.|.|||.|..:...|... .||:.....|    .|:.|::.    .|:.::
  Rat   422 GRPIPWVKG--APPLDNPPCAFDLDDPSCDKTPLSTLAIVALG----TGITFIMFGVSSFLIFRK 480

  Fly   563 MKLSKELNNMSWRVRPDDVLIEMGGMFGS-----KGGLQRLDVENISLQQFGIHSGRASIASFTS 622
            :.|.|||.:|.||:|.:::      .||:     ||...||   .:||:.          :|:.|
  Rat   481 LMLEKELASMLWRIRWEEL------QFGNSDRYHKGAGSRL---TLSLRG----------SSYGS 526

  Fly   623 LPP-----QVYTTIGQFKGERVAIKKVNVKKVDLTPQLLWEIKQARDVSHENTVRFVGACIDLPR 682
            |..     |::...|.|||..||||.||.|:::||.|:|:|:|..|||...:..||:|||||  .
  Rat   527 LMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACID--P 589

  Fly   683 PTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDG 747
            |.:.|:||||.||||:|:|||::|.|||.||.|||:|:||||.:||||.:::||.|:|.||::|.
  Rat   590 PNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDS 654

  Fly   748 RFVLKISDFGL---RTLTTPSDFVRDQNYYLKLLWIAPELL---PLTTIPGCCPATQRGDVYSFG 806
            ||||||:|:||   |:...|.|   ....|.|.||.|||||   ||.|     ...|:.|||||.
  Rat   655 RFVLKITDYGLASFRSTAEPDD---SHALYAKKLWTAPELLSGNPLPT-----TGMQKADVYSFA 711

  Fly   807 IILEEIVNRGGPYQEARQQMDVHTILHKVRQCNG----FRPLIRERECPPDLLELMEKCWADNQE 867
            |||:||..|.||:......:....|:.|||  ||    |||.|...:...:|:.|||:|||.:..
  Rat   712 IILQEIALRSGPFYLEGLDLSPKEIVQKVR--NGQRPYFRPSIDRTQLNEELVLLMERCWAQDPT 774

  Fly   868 ERPTFSTIRSNIRTIMKGFCENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILP 932
            |||.|..|:..||...|....:::|:||.||||||||||.||||:|:....||::.|.|||||||
  Rat   775 ERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILP 839

  Fly   933 RPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYK 997
            ..||:||..|:.|:.|.|.|||||||||||||.|.|.|:||.||..|||||:.||.||..:||||
  Rat   840 HSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYK 904

  Fly   998 VETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGV 1062
            ||||||||:||||||..||.:||.|||.|||.:|.|||||.:||:|..::::|||:|:|.|||||
  Rat   905 VETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGV 969

  Fly  1063 VGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVELKGKGTVTTY 1127
            ||.|||.||||||||||||||||.||..||||||.||..||:.|.||:|.|||||:||||.:.||
  Rat   970 VGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTY 1034

  Fly  1128 WLNSTSEGEARPP 1140
            ||....:|   ||
  Rat  1035 WLLGERKG---PP 1044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_GC-like	90..501	CDD:380575	119/449 (27%)
		Protein Kinases, catalytic domain	616..885	CDD:473864	132/283 (47%)
		HNOBA	<891..939	CDD:462234	30/47 (64%)
		CYCc	918..1109	CDD:214485	128/190 (67%)
Npr2	NP_446290.1	PBP1_NPR_B	26..421	CDD:380607	119/448 (27%)
		PK_GC-A_B	518..792	CDD:270944	134/295 (45%)
		HNOBA	<798..846	CDD:462234	30/47 (64%)
		CYCc	825..1009	CDD:214485	125/183 (68%)