DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and Gucy2f

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_446283.1	Gene:	Gucy2f / 116556	RGDID:	620439	Length:	1108	Species:	Rattus norvegicus

Alignment Length:	1111	Identity:	370/1111 - (33%)
Similarity:	567/1111 - (51%)	Gaps:	147/1111 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 YNVGVLMASHLDSPFDLERCGPAVDLALDEINKVFLKPHNITLLKKKGSY------------PSC 141
            |.:||:      .|:   .|.|....||.|:.....    |..:.:..|:            ..|
  Rat    53 YKIGVI------GPW---TCDPFFSKALPEVAAALA----IERISRDMSFDRSYSFEYVILNEDC 104

  Fly   142 SGARAPGLAADMYFQDDVIAFIGPACAFALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTSGI 206
            ..::|  |.:.:..|.....|:|||.....|..:.|...|:|.|.:
  Rat   105 QTSKA--LTSFISHQQMASGFVGPANPGYCEAASLLGNSWDKGIFS------------------- 148

  Fly   207 LGRIHKWKNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNWNHVALLVDRSELFSWTVG 271
                  |...|..: .:|..|||.:|......|   |..:|::.|.|.|..::....:::..|..
  Rat   149 ------WACVNHEL-DNKHSYPTFSRTLPSPIR---VLVTVMKYFQWAHAGVISSDEDIWVHTAN 203

  Fly   272 KNLEYGLRQEGLLSFVKELNGNEEEVYENYLKDASM--YARVVILSVRGVLV-----RKFMLAAH 329
            : :...||..||...|...:|.:....:..|:....  ..|::|:.:...|:     ..|:..||
  Rat   204 Q-VSSALRSHGLPVGVVLTSGQDSRSIQKALQQIRQADRIRIIIMCMHSALIGGETQTHFLELAH 267

  Fly   330 SLGMTNGEWVFL--DVEIFQSEYWGDKGWEMKDEHDAKARKAYEALLRVSLLQPTSPKFQDFAD- 391
            .|.||:|.:||:  ||.::...|.......::  ::.|.|:||:|:|.:::.......::.|.:
  Rat   268 DLKMTDGTYVFVPYDVLLYSLPYKHSPYQVLR--NNQKLREAYDAVLTITVESHEKTFYEAFTEA 330

  Fly   392 ----NVRENALYDYNYTFGEGEEVNFFIGAFYDGVYLLGMALNETLTEGGDIRDGVNITRRMWNR 452
                .:.|..         :..:|:...|..|:.:|.:..|::..|.|.|. ....::||...|.
  Rat   331 AAGGEIPEKL---------DSHQVSPLFGTIYNSIYFIAQAMSNALKENGQ-ASAASLTRHSRNM 385

  Fly   453 TFEGITGHVRIDDNGDRDADYSILDLD----PINGKFSVVAHYSGVHKVYSAVHGKKIHWPGGRE 513
            .|.|....:|.|.||:..::|.|||.:    .:.|.::|     .:........|..||:||||
  Rat   386 QFYGFNQLIRTDSNGNGISEYVILDTNGKEWELRGTYTV-----DMETELLRFRGTPIHFPGGR- 444

  Fly   514 EPPPDVPPCGFLGNSTDCVGNF--STIMYSVFGLLLFL----GLVFLVICLLQKQMKLSKELNNM 572
             |......|.| .....|.|..  :..|...|.|||.|    |..:.:          .:.:|.:
  Rat   445 -PTSADAKCWF-AQGKICQGGIDPALAMMVCFALLLALLSINGFAYFI----------RRRINKI 497

  Fly   573 SWRVRPDDVLIEMGGM------FGSKGGLQRLDVENISLQQFG-IHSGRASIASFT--SLPPQVY 628
            .....|:.:|:.:..:      ||||.|.:    .::|.|... :.|||:...||:  ||.|..|
  Rat   498 QLIKGPNRILLTLEDVTFINPHFGSKRGSR----ASVSFQIISEVQSGRSPRLSFSSGSLTPATY 558

  Fly   629 --TTIGQFKGERVAIKKV------NVKKVDLTPQLLWEIKQARDVSHENTVRFVGACIDLPRPTV 685
              :.|..::|:.|.:||.      ::|.:..:...::|:  .:|:.|||....:|...|  ....
  Rat   559 ENSNIAIYQGDWVWLKKFPPGDFGDIKSIKSSASDVFEM--MKDLRHENVNPLLGFFYD--SGMF 619

  Fly   686 LILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFV 750
            .|::|:|||.||:|:|..:.::|||.|:.||:.|::|||.|||:.:. .||:|:|.||::|||||
  Rat   620 AIVSEFCSRRSLEDILTQDDVKLDWMFKSSLLLDLIKGMKYLHHREF-IHGRLKSRNCVVDGRFV 683

  Fly   751 LKISDFGLRTLTTPSDFVRDQNYYLKLLWIAPELLPLTTIPGCCP-ATQRGDVYSFGIILEEIVN 814
            ||::|:|...:........::....:|||.|||||   ..||... .:..||||||.||::|::.
  Rat   684 LKVTDYGFNNILEMLRLSEEEPSEEELLWTAPELL---RAPGGIRLGSFAGDVYSFAIIMQEVMV 745

  Fly   815 RGGPYQEARQQMDVHTILHKVRQCNG-FRPLIRERECPPDLLELMEKCWADNQEERPTFSTIRSN 878
            ||.|:  ....:....::.:::.... :||::.....||:.|:||::|||:..|:||||..|.:.
  Rat   746 RGAPF--CMMDLSAKEVIDRLKMPPPVYRPVVSPEFAPPECLQLMKQCWAEAAEQRPTFDEIFNQ 808

  Fly   879 IRTIMKGFCENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGD 943
            .:|..||...|::|.:|..:|||::|||.|:.|:|.:|.:|||:||:||.|:||..||:.|..|.
  Rat   809 FKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGC 873

  Fly   944 LVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVV 1008
            .||||.|..||:|||||||||.:.|.|.|::||:.|||||:.||.|||.:||||||||||||:|.
  Rat   874 TVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVA 938

  Fly  1009 SGLPEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLF 1073
            ||||:.||.:||.|||.|:||||.:|.:|.:||.||..::||||:|:|.|.|||||..||.||||
  Rat   939 SGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHTGPVVAGVVGLTMPRYCLF 1003

  Fly  1074 GDTVNTASRMESTGQPGKIHVSSATKAILDKFGT-FQMEQRGDVELKGKGTVTTYWLNSTSEGEA 1137
            ||||||||||||||.|.:||||.:|..||..... :::|.||..|||||||..|:||.. .:|..
  Rat  1004 GDTVNTASRMESTGLPYRIHVSLSTVTILRTLSEGYEVELRGRTELKGKGTEETFWLVG-KKGFT 1067

  Fly  1138 RP-PTP 1142
            :| |.|
  Rat  1068 KPLPVP 1073

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	90/435 (21%)
		ANF_receptor	107..479	CDD:279440	85/397 (21%)
		PKc_like	616..885	CDD:304357	95/280 (34%)
		TyrKc	627..877	CDD:197581	89/259 (34%)
		HNOBA	<882..939	CDD:285003	27/56 (48%)
		CYCc	918..1109	CDD:214485	120/191 (63%)
		Guanylate_cyc	945..1131	CDD:278633	119/186 (64%)
Gucy2f	NP_446283.1	PBP1_sensory_GC_DEF_like	54..435	CDD:107366	90/442 (20%)
		ANF_receptor	75..412	CDD:279440	80/384 (21%)
		PKc_like	545..815	CDD:304357	95/279 (34%)
		TyrKc	565..809	CDD:197581	87/253 (34%)
		HNOBA	<824..869	CDD:285003	23/44 (52%)
		CYCc	848..1040	CDD:214485	120/191 (63%)
		Guanylate_cyc	875..1062	CDD:278633	119/186 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820