DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and Adcy8

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_033753.2	Gene:	Adcy8 / 11514	MGIID:	1341110	Length:	1249	Species:	Mus musculus

Alignment Length:	1113	Identity:	225/1113 - (20%)
Similarity:	391/1113 - (35%)	Gaps:	351/1113 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 CRLILVFASVIRQFNWNHVALLVDRSELFSWT------VGKNLEYGLRQEGLLSFV--------- 287
            |.|:     |:|:.|.:|..|  ..|.:.:|.      :...|.|||..:| :.:|
Mouse   225 CALV-----VVRKDNTSHTYL--QYSGVVTWVAMTTQILAAGLGYGLLGDG-IGYVLFTLFATYS 281

  Fly   288 --------KELNGNEEEVYENYLKDASMYARVVILSVRGVLVRKFMLAAHSLGMTNGEWVFLDVE 344
                    ..|.|....:.:..|:  .:..|:.:.|:..||.:..:...     .|...:|:
Mouse   282 MLPLPLTWAILAGLGTSLLQVTLQ--VLIPRLAVFSINQVLAQVVLFMC-----MNTAGIFI--- 336

  Fly   345 IFQSEYWGDKGWEMKDEHDAKARKAYEALLRVS--------LLQPTSPKF------QDFADNVRE 395
                .|..|:.   :.:...:.|:..||.||:.        |:....|:|      .|..:...|
Mouse   337 ----SYLSDRA---QRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDE 394

  Fly   396 NALYDYNYTFGEGEEVNFFIGAFYDGVYLLGMALNETLTEGGDIRDGVNITRRMWNRTFEGITGH 460
            :..:.::         ..:|.. |:.|.:|          ..|::...|::..:
Mouse   395 HLQHQFH---------RIYIHR-YENVSIL----------FADVKGFTNLSTTL----------- 428

  Fly   461 VRIDDNGDRDADYSILDLDPINGKFSVVAHYSGVHKVYSAVHGKKIHWPGGREEPPPDVPPCGFL 525
                     .|...:..|:.:..:|..:||..  |.:...:.|...:...|..||..|...|
Mouse   429 ---------SAQELVRMLNELFARFDRLAHEH--HCLRIKILGDCYYCVSGLPEPRRDHAHC--- 479

  Fly   526 GNSTDCVGNFSTIMYSVFGLLLFLGLVFLVICLLQKQMKLSKELNNMSWRVRPDDVLIEMGGMFG 590
                 ||         ..||.:...:.|:          .|:..:::..|:.     |..|.:..
Mouse   480 -----CV---------EMGLSMIKTIRFV----------RSRTKHDVDMRIG-----IHSGSVLC 515

  Fly   591 SKGGLQR---------LDVENISLQQFGIHSGRASI--ASFTSLPPQVYTTIGQFKGERVAIKKV 644
            ...||::         :|:.| .|:..|| .||..|  |:...|........|..|.....::|.
Mouse   516 GVLGLRKWQFDVWSWDVDIAN-KLESGGI-PGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKH 578

  Fly   645 NVKKVDLTPQLLWEIKQARD---VSHENTVRFVGACID----------------LPRPTVLILTE 690
            |::        .:.|||..:   ...|:.|:...:|.|                ||...::
Mouse   579 NIE--------TYLIKQPEESLLCLPEDIVKESVSCSDRRNSGATFTEGSWSPELPFDNIV---- 631

  Fly   691 YCSRGSLKDVLENEAIELDWNFRMSLIH------DIVKGMNYLHNSDVAAHGKLRSCNCLIDGRF 749
              .:.:....|...:|.|..|.....:|      :|.|.:.  |..|:.:..|||..:
Mouse   632 --GKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIE--HTIDLRSGDKLRREH------- 685

  Fly   750 VLKISDFGL----RTLTTPSDFVRDQNYYLKLLWIAPELLPLTTIPGCCPATQRGDV-YSFGIIL 809
               |..|.|    .:|......:||:.:...|:.....||.:|.|....|:::...: ..|.|::
Mouse   686 ---IKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRLMPMTIQFSILI 747

  Fly   810 EEIVNRGGPYQEARQQMDVHTILHKVRQCNGFR--PLIRERECP--------------PDLL--- 855
            .                 :|:.|..:.....::  |||..:.|.              ..:|
Mouse   748 M-----------------LHSALVLITTAEDYKCLPLILRKTCCWINETYLARNVIIFASILINF 795

  Fly   856 --ELMEKCWADNQEERP----TFST----------------------------IRSN-------- 878
              .::...|.|..:..|    ||::                            :|.|
Mouse   796 LGAVLNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVL 860

  Fly   879 ----------IRTIMKGF---CENLM---DDLLNRME--------------------QYANNLES 907
                      ..||..|.   .:||.   :|.|...|                    :|...|:.
Mouse   861 LIMIAIYALLTETIYAGLFLSYDNLNHSGEDFLGTKEASLLLMAMFLLAVFYHGQQLEYTARLDF 925

  Fly   908 L----VEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFS----SVTIYFSDIVGFT 964
            |    .:|:..::...::..|.:|..|||..||:..:..|....|.:|    :|.:.|:.|.||.
Mouse   926 LWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFA 990

  Fly   965 ELCAR----SSPMDVVNFLNDLYSTFDRIIG---FYDVYKVETIGDAYLVVSGL-PEPN--GDK- 1018
            :..::    :..::.:..||::.:.||.::|   |.|:.|::|||..|:.|||| ||..  .||
Mouse   991 DFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKW 1055

  Fly  1019 -HAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASR 1082
             |...:|..:|.:..::...| :|... ..::|||:..|||.|||:|.|.|.|.::|.|||.|||
Mouse  1056 GHLCALADFSLALTESIQEIN-KHSFN-NFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASR 1118

  Fly  1083 MESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVELKG----KGTVTTYWLNSTSEGEARPPTPQ 1143
            |:|||..|:|.|...|..||...| |..:.||::.:||    :|.:.||:|....:     |.|.
Mouse  1119 MDSTGVSGRIQVPEETYLILKDQG-FAFDYRGEIYVKGISEQEGKIKTYFLLGRVQ-----PNPF 1177

  Fly  1144 ILTTDEVP 1151
            ||....:|
Mouse  1178 ILPPRRLP 1185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	47/294 (16%)
		ANF_receptor	107..479	CDD:279440	43/277 (16%)
		PKc_like	616..885	CDD:304357	58/371 (16%)
		TyrKc	627..877	CDD:197581	51/332 (15%)
		HNOBA	<882..939	CDD:285003	18/86 (21%)
		CYCc	918..1109	CDD:214485	71/206 (34%)
		Guanylate_cyc	945..1131	CDD:278633	72/205 (35%)
Adcy8	NP_033753.2	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..180
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..107
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..33
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	38..40
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	49..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..118
		AC_N	<159..398	CDD:292831	36/197 (18%)
		CYCc	364..562	CDD:214485	44/273 (16%)
		Guanylate_cyc	403..587	CDD:278633	44/258 (17%)
		DUF1053	615..709	CDD:283888	20/111 (18%)
		CYCc	942..1146	CDD:214485	72/206 (35%)
		Guanylate_cyc	971..1170	CDD:278633	71/201 (35%)
		Involved in CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1107..1249		32/85 (38%)
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250\|UniProtKB:P40146	1198..1213
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1221..1249
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900