DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3216 and ADCY8

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_001106.1	Gene:	ADCY8 / 114	HGNCID:	239	Length:	1251	Species:	Homo sapiens

Alignment Length:	276	Identity:	89/276 - (32%)
Similarity:	143/276 - (51%)	Gaps:	32/276 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   900 QYANNLESL----VEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFS----SVTIY 956
            :|...|:.|    .:|:..::...::..|.:|..|||..||:..:..|....|.:|    :|.:.
Human   920 EYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVM 984

  Fly   957 FSDIVGFTELCAR----SSPMDVVNFLNDLYSTFDRIIG---FYDVYKVETIGDAYLVVSGL-PE 1013
            |:.|.||.:..::    :..::.:..||::.:.||.::|   |.|:.|::|||..|:.|||| ||
Human   985 FASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPE 1049

  Fly  1014 PN--GDK--HAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFG 1074
            ..  .||  |...:|..:|.:..::...| :|... ..::|||:..|||.|||:|.|.|.|.::|
Human  1050 KQQCEDKWGHLCALADFSLALTESIQEIN-KHSFN-NFELRIGISHGSVVAGVIGAKKPQYDIWG 1112

  Fly  1075 DTVNTASRMESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVELKG----KGTVTTYWLNSTSEG 1135
            .|||.||||:|||..|:|.|...|..||...| |..:.||::.:||    :|.:.||:|....:
Human  1113 KTVNLASRMDSTGVSGRIQVPEETYLILKDQG-FAFDYRGEIYVKGISEQEGKIKTYFLLGRVQ- 1175

  Fly  1136 EARPPTPQILTTDEVP 1151
                |.|.||....:|
Human  1176 ----PNPFILPPRRLP 1187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368
		ANF_receptor	107..479	CDD:279440
		PKc_like	616..885	CDD:304357
		TyrKc	627..877	CDD:197581
		HNOBA	<882..939	CDD:285003	11/42 (26%)
		CYCc	918..1109	CDD:214485	71/206 (34%)
		Guanylate_cyc	945..1131	CDD:278633	72/205 (35%)
ADCY8	NP_001106.1	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..182
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..109
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	38..40
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	49..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..92
		AC_N	<161..400	CDD:292831
		CYCc	366..564	CDD:214485
		Guanylate_cyc	405..589	CDD:278633
		DUF1053	617..711	CDD:283888
		CYCc	944..1148	CDD:214485	72/206 (35%)
		Guanylate_cyc	973..1172	CDD:278633	71/201 (35%)
		Involved in CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1109..1251		32/85 (38%)
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250\|UniProtKB:P40146	1200..1215
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1223..1251
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810