DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and Gucy2e

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_570093.2	Gene:	Gucy2e / 113911	RGDID:	69322	Length:	1123	Species:	Rattus norvegicus

Alignment Length:	1170	Identity:	401/1170 - (34%)
Similarity:	576/1170 - (49%)	Gaps:	171/1170 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 AGLEQRMYERSRE--SKSTQLSRYTEVGEMGSTMR---------VYNV---GVLM-ASHLDSP-- 102
            |||:|..:...::  :...:..|..: |..|.|:|         |::|   |||: |..|..|
  Rat     2 AGLQQGCHPEGQDWTAPHWKTCRPCQ-GPRGLTVRHLRTVSSISVFSVVFWGVLLWADSLSLPAW 65

  Fly   103 ----FDLERCGP--------------AVDLALDEINKVFLKPHNITLLKKKGS------YPSCSG 143
                |.|...||              |..||:|.:|:      :.:||  .||      .|  :|
  Rat    66 ARETFTLGVLGPWDCDPIFAQALPSMATQLAVDRVNQ------DASLL--LGSQLDFKILP--TG 120

  Fly   144 ARAP-GLAADMYFQDDVIAFIGPACAFALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTSGIL 207
            ...| .||..:..::.|.|||||.........|.||..|.|.:.:.....|   ||     .|.|
  Rat   121 CDTPHALATFVAHRNTVAAFIGPVNPGYCPAAALLAQGWGKSLFSWACGAP---EG-----GGAL 177

  Fly   208 GRIHKWKNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNWNHVALLVDRSELFSW-TVG 271
                               .|||..|:.       |..||:|.|.|..:|::....::  | |..
  Rat   178 -------------------VPTLPSMAD-------VLLSVMRHFGWARLAIVSSHQDI--WVTTA 214

  Fly   272 KNLEYGLRQEGL-LSFVKELNGNEEEVYENYLKDASMYA-RVVILSVRGVLV-----RKFMLAAH 329
            :.|....|..|| :..:..|...|:...|...:..|::. ::|:|.:...|:     ...:..|.
  Rat   215 QQLATAFRAHGLPIGLITSLGPGEKGATEVCKQLHSVHGLKIVVLCMHSALLGGLEQTVLLRCAR 279

  Fly   330 SLGMTNGEWVFL--DVEIFQSEYWGDKGWEMKDEHDAKARKAYEALLRVSLLQPTSPKFQDF-AD 391
            ..|:|:|..|||  |..:|...| .::.:.:.|: |...::||:|:|.:||  .|||:...| |.
  Rat   280 KEGLTDGRLVFLPYDTLLFALPY-RNRSYLVLDD-DGPLQEAYDAVLTISL--DTSPESHAFTAT 340

  Fly   392 NVRENALYDYNYTFGEGEEVNFFIGAFYDGVYLLGMALNETLTEGGDIRDGVNITRRMWNRTFEG 456
            .:|.....:..     .|:|:...|..||.|.||..|||.:...|..: .|.::...:......|
  Rat   341 KMRGGTAANLG-----PEQVSPLFGTIYDAVILLAHALNHSEAHGTGL-SGAHLGNHIRALDVAG 399

  Fly   457 ITGHVRIDDNGDRDADYSILDLDPINGKFS--VVAHYSGVHKVYSAVHGKKIHWPGGREEPPPDV 519
            .:..:|||..|.|...|.|||   .||:.|  |..|...|........|..:|:|||  .||...
  Rat   400 FSQRIRIDGKGRRLPQYVILD---TNGEGSQLVPTHILDVSTQQVQPLGTAVHFPGG--SPPARD 459

  Fly   520 PPCGFLGNSTDCV------GNFSTIMYSVFGLLLFLGLVFLVICLLQKQMKLSKE---------- 568
            ..|.|..| |.|:      |:..|:..:.. |.|..|.:...|.|..:|::|.:.
  Rat   460 ASCWFDPN-TLCIRGVQPLGSLLTLTITCV-LALVGGFLAYFIRLGLQQLRLLRGPHRILLTPQE 522

  Fly   569 ---LNNMSWRVRPDDVLIEMGGMFGSKGGLQRLDVENISLQQFGIHSGRASIASFTSLPPQVYTT 630
               |.....|.||          ....|...|..|:..|.|.. |.....|:.:|..     :|.
  Rat   523 LTFLQRTPSRRRP----------HVDSGSESRSVVDGGSPQSV-IQGSTRSVPAFLE-----HTN 571

  Fly   631 IGQFKGERVAIKKVNVKKV-DLTPQLLWEIKQARDVSHENTVRFVGACIDLPRPTVLILTEYCSR 694
            :..::||.|.:||...... ||.|..|..:::.|::.|||...|:|..:. |..:.::| |:|:|
  Rat   572 VALYQGEWVWLKKFEAGTAPDLRPSSLSLLRKMREMRHENVTAFLGLFVG-PEVSAMVL-EHCAR 634

  Fly   695 GSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGLR 759
            |||:|:|.||.:.|||.|:.||:.|:::|:.|||:... .||:|:|.||::|.||||||:|.|..
  Rat   635 GSLEDLLRNEDLRLDWTFKASLLLDLIRGLRYLHHRHF-PHGRLKSRNCVVDTRFVLKITDHGYA 698

  Fly   760 TLTTPSDFVRDQNYYLKLLWIAPELLPLTTIP-GCCPATQRGDVYSFGIILEEIVNRGGPYQEAR 823
            .........|.|....:|||.|||||.....| |...||.:|||:|.||||:|::.|..||  ..
  Rat   699 EFLESHCSFRPQPAPEELLWTAPELLRGPRRPWGPGKATFKGDVFSLGIILQEVLTRDPPY--CS 761

  Fly   824 QQMDVHTILHKVRQ----CNGFRPLIRERECPPDLLELMEKCWADNQEERPTFSTIRSNIRTIMK 884
            ..:....|:.||..    |   |||:...:.|.:.::||:.||.:..::||:...|.:..::|.:
  Rat   762 WGLSAEEIIRKVASPPPLC---RPLVSPDQGPLECIQLMQLCWEEAPDDRPSLDQIYTQFKSINQ 823

  Fly   885 GFCENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEE 949
            |...::.|.:|..:|:|:.:||.||:|:|.:|.||:::||.||.|:||..||..|..|..||||.
  Rat   824 GKKTSVADSMLRMLEKYSQSLEGLVQERTEELELERRKTERLLSQMLPPSVAHALKMGTTVEPEY 888

  Fly   950 FSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEP 1014
            |..||||||||||||.:.|.|.|::||.||||||:.||.::..:||||||||||||:|.||||..
  Rat   889 FDQVTIYFSDIVGFTTISALSEPIEVVGFLNDLYTMFDAVLDSHDVYKVETIGDAYMVASGLPRR 953

  Fly  1015 NGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNT 1079
            ||::||.|||.|||:||....:|.:||.|:..|::|.|:|||...|||||..||.||||||||||
  Rat   954 NGNRHAAEIANMALEILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNT 1018

  Fly  1080 ASRMESTGQPGKIHVSSAT-KAILDKFGTFQMEQRGDVELKGKGTVTTYWLNSTSEGEARP-PTP 1142
            ||||||||.|.:||||..| :|:|.....::::.||..||||||...||||...: |..|. |||
  Rat  1019 ASRMESTGLPYRIHVSRNTVQALLSLDEGYKIDVRGQTELKGKGLEETYWLTGKT-GFCRSLPTP 1082

Fly 1143 1142
Rat 1083 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	118/449 (26%)
		ANF_receptor	107..479	CDD:279440	103/403 (26%)
		PKc_like	616..885	CDD:304357	98/274 (36%)
		TyrKc	627..877	CDD:197581	95/255 (37%)
		HNOBA	<882..939	CDD:285003	24/56 (43%)
		CYCc	918..1109	CDD:214485	115/191 (60%)
		Guanylate_cyc	945..1131	CDD:278633	114/186 (61%)
Gucy2e	NP_570093.2	PBP1_sensory_GC_DEF-like	71..445	CDD:380594	110/432 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..556		8/37 (22%)
		PK_GC-2D	554..824	CDD:270945	99/283 (35%)
		CYCc	861..1050	CDD:214485	113/188 (60%)
		Interaction with NCALD. /evidence=ECO:0000269\|PubMed:18178149	880..921		26/40 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820