DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3216 and ADCY6

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_001377760.1	Gene:	ADCY6 / 112	HGNCID:	237	Length:	1168	Species:	Homo sapiens

Alignment Length:	1047	Identity:	220/1047 - (21%)
Similarity:	377/1047 - (36%)	Gaps:	377/1047 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 RIHKWKNENTG-MFKDKSKYPTLTRMSYCQCR-LILVFASVIRQFN----WNHVALLVDRSELFS 267
            :|:..|::|.. :|.|...:.:|.  |.|..: |::....:..:|:    .||...:....:.:.
Human   369 KIYIQKHDNVSILFADIEGFTSLA--SQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYY 431

  Fly   268 WTVGKN----------LEYGLRQEGLLSFVKELNGNEEEVYENYLKDASMYARVVILSVR---GV 319
            ...|..          :|.|:.....:|.|:|:.|            .::..||.|.|.|   ||
Human   432 CVSGLPEARADHAHCCVEMGVDMIEAISLVREVTG------------VNVNMRVGIHSGRVHCGV 484

  Fly   320 L-VRKFM---------LAAH---------------SLGMTNGEWVFLDVEIFQSEYWGDKGWEMK 359
            | :||:.         ||.|               :|...||::   :||..:.   |::...:|
Human   485 LGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDY---EVEPGRG---GERNAYLK 543

  Fly   360 DEH--------DAKARKAYEALL------RVSLLQPTSPKFQDFADNVRENALYDYNYTFGEGEE 410
            ::|        .::.||..:|:|      |.:.::...|::      |.:.|       |...::
Human   544 EQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRW------VPDRA-------FSRTKD 595

  Fly   411 VNFFIGAFYDGVYLLGMALNETLTEGGDIRDGVN--------ITRRMWNRTFEGI-TGHVRIDDN 466
            ...|          ..|.::::..:....:|.:|        ::|.:..|:.:.: ..|||
Human   596 SKAF----------RQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVR---- 646

  Fly   467 GDRDADYSILDLDPINGKFSVVAHYSGVHKVYSAVHGKKIHWPGGREEPPPDVPPCGFLGNSTDC 531
                             :|.:......:.|.||    :|:....|.      ...|..|.....|
Human   647 -----------------RFLLTFQREDLEKKYS----RKVDPRFGA------YVACALLVFCFIC 684

  Fly   532 -----VGNFSTIMYSVFGLLLFLGLVFLVICLLQKQMKLSKELNNMSWRVRPDDVLIEMGGMFGS 591
                 :...||:|..::..:..|.|:.::||                       .:...|.:|..
Human   685 FIQLLIFPHSTLMLGIYASIFLLLLITVLIC-----------------------AVYSCGSLFPK 726

  Fly   592 KGGLQRLDVENISLQQFGIHSGRASIAS----FTSLPPQVYTTIGQFKGERVAIKKVNVKKVDLT 652
              .||||   :.|:.:...||....|.|    |||....::|.      ....|:....:.::||
Human   727 --ALQRL---SRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTC------NHTPIRSCAARMLNLT 780

  Fly   653 PQLLWEIKQARDVSHENTVRFVGAC----------IDLP-----RPTVLILTEYCSRGSLKDVLE 702
            |         .|::         ||          :|.|     .|| ....||
Human   781 P---------ADIT---------ACHLQQLNYSLGLDAPLCEGTMPT-CSFPEY----------- 815

  Fly   703 NEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGLRTLTTPSDF 767
                 ...|..:||:...|    :||.|.:   |||...       |||     ||
Human   816 -----FIGNMLLSLLASSV----FLHISSI---GKLAMI-------FVL-----GL--------- 847

  Fly   768 VRDQNYYLKLLWIAPELLPLTTIPGCCPATQRGDVY-SFGIILEEIVNRGGPYQEARQQMDVHTI 831
                 .||.||.:.|            |||    :: ::.::|                 .||.:
Human   848 -----IYLVLLLLGP------------PAT----IFDNYDLLL-----------------GVHGL 874

  Fly   832 LHKVRQCNGFRPLIRERECPPDLLELMEKCWADNQEERPTFSTIRSNIRTIMKGFCENLMDDLLN 896
            .......:|.       :||                         :..|..:|     .|..::.
Human   875 ASSNETFDGL-------DCP-------------------------AAGRVALK-----YMTPVIL 902

  Fly   897 RMEQYANNLESLVEEKTRQLSL--------EKQRTEE-------LLYQILPRPVAQQLMA----G 942
            .:...|..|.:...|.|.:|..        ||:..||       ||:.|||:.||...:|    .
Human   903 LVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRN 967

  Fly   943 DLVEPEEFSSVTIYFSDIVGFT----ELCARSSPMDVVNFLNDLYSTFDRIIG---FYDVYKVET 1000
            |.:..:....|.:.|:.|..|:    ||.|.:..::.:..||::.:.||.||.   |..:.|::|
Human   968 DELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKT 1032

  Fly  1001 IGDAYLVVSGLP----EPNGDKHAREIALMALDILRAVSSFNLRHKPEY---KIQIRIGMHSGSV 1058
            ||..|:..|||.    :..|..|...:|..|:.::.     .::|..|:   ..|::||::.|.|
Human  1033 IGSTYMAASGLNASTYDQVGRSHITALADYAMRLME-----QMKHINEHSFNNFQMKIGLNMGPV 1092

  Fly  1059 CAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVELKGKGT 1123
            .|||:|.:.|.|.::|:|||.:|||:|||.|.:|.|::....:|...| :|:|.||.|::||||.
Human  1093 VAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG-YQLECRGVVKVKGKGE 1156

  Fly  1124 VTTYWLN 1130
            :|||:||
Human  1157 MTTYFLN 1163

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	59/353 (17%)
		ANF_receptor	107..479	CDD:279440	58/336 (17%)
		PKc_like	616..885	CDD:304357	49/288 (17%)
		TyrKc	627..877	CDD:197581	43/265 (16%)
		HNOBA	<882..939	CDD:285003	18/71 (25%)
		CYCc	918..1109	CDD:214485	67/223 (30%)
		Guanylate_cyc	945..1131	CDD:278633	68/200 (34%)
ADCY6	NP_001377760.1	AC_N	<16..368	CDD:318454
		Guanylate_cyc	370..554	CDD:306677	40/203 (20%)
		DUF1053	582..668	CDD:399378	18/133 (14%)
		Guanylate_cyc	970..1164	CDD:306677	68/200 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810