DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and npr1

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	XP_031747254.1	Gene:	npr1 / 100492092	XenbaseID:	XB-GENE-970522	Length:	1053	Species:	Xenopus tropicalis

Alignment Length:	1075	Identity:	432/1075 - (40%)
Similarity:	625/1075 - (58%)	Gaps:	108/1075 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 PFDLERCGPAVDLALDEINKVFLKPHNITLLK----------KKGSYPSCSGARAPGLAADMYFQ 156
            |:...|.|||:.:|::.||:   .|..:..|:          |.|   :||.:.||.:|.|:.|.
Frog    40 PWAWPRVGPAIHMAIERINR---DPALLPDLRVQTFFGDSEDKDG---NCSDSTAPVVAVDLQFT 98

  Fly   157 DDVIAFIGPACAFALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTSGILGRIHKWKNENTGMF 221
            .....|:||.|.:...||||..|:|..|:|              ||.:...|            |
Frog    99 HHPEVFLGPGCIYTAAPVARFTAHWKVPLI--------------TVGAAAFG------------F 137

  Fly   222 KDKSK-YPTLTRMSYCQCRLILVFASVIRQFNWNHVALLV-------DRSELFSWTVGKNLEYGL 278
            .|||. |...||......:|......:.:::||:..|::|       ||...|:..       ||
Frog   138 NDKSDVYQYTTRTGLIPTKLGQFVGHIHQRYNWSSRAMIVYRDSSLDDRPCFFTME-------GL 195

  Fly   279 RQEGLLSF---VKELNGNEEEV--YENYLKDASMYARVVILSVRGVLVRKFMLAAHSLGMTNGEW 338
            ..| ||.|   |.:|...::|:  |.:.:.|.....|::.:.....:.|:.|:.|...|:.:|::
Frog   196 YME-LLKFNLTVLDLQFKDKELTNYTSLIHDIKQKGRIIYMCCYPDMFRQLMIQAWREGLCSGDY 259

  Fly   339 VFLDVEIFQSEYWG------DKGWEMKDEHDAKARKAYEALLRVSLLQPTSPKFQDFADNVRENA 397
            .|..|:|:.:...|      .:.|...|..|||||:|::|::.::..:|.:|::::|..|:...:
Frog   260 AFFYVDIWGASLQGAIFPDPQRPWYRGDPDDAKAREAFKAVMIITYKEPDNPEYREFLANLSRYS 324

  Fly   398 LYDYNYTFGEGEEVNFFIGAFYDGVYLLGMALNETLTEGGDIRDGVNITRRMWNRTFEGITGHVR 462
            ...:.|. .|...:|....:|:|.|.|...|:|||...|..:::...:|..|.|::|.|.:|.|:
Frog   325 EAPFYYR-QESTLMNALSASFHDSVLLYAHAVNETRANGYSMKNASAVTSYMRNKSFYGASGFVK 388

  Fly   463 IDDNGDRDADYSILDLDPINGKFSVVAHYSGVHKVYSAVHGKKIHWPGGREEPPPDVPPCGFLGN 527
            |||||||:.|:|:.|:...:|.|.:|.:|:|..:....:.|::|.|||.|  .|.|||||||..:
Frog   389 IDDNGDRENDFSLWDMYEPHGTFQIVYNYNGTLRKIVPLPGREIEWPGNR--IPRDVPPCGFDHS 451

  Fly   528 STDCVGNFSTIMYSVFGLLLFLGLVFLVICL-LQKQMKLSKELNNMSWRVRPDDV----LIEMGG 587
            ...|..:..||:..:..::.|:.|:..|..: :.::::|.|||....||:|.:|:    |.:...
Frog   452 DPKCKKSSFTILEILSIVICFILLIITVSSIFIYRKLRLEKELAAELWRIRWEDIHTSNLEKNLR 516

  Fly   588 MFGSKGGLQRLDVENISLQQFGIHSGRASIASFTSLPPQVYTTIGQFKGERVAIKKVNVKKVDLT 652
            ..|||          ::|...|.:.|  |:.: |....|:|.....:||..:|:|.:|.|:::||
Frog   517 RAGSK----------LTLSLRGSNYG--SLLT-TEGQFQIYAKTAYYKGNIIAVKHINRKRIELT 568

  Fly   653 PQLLWEIKQARDVSHENTVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLI 717
            .::|:|:|..|||.:|:..||||:|||  .|.:.||||||.||||:|:||||:|.|||.||.|||
Frog   569 RKVLFELKHMRDVQNEHLTRFVGSCID--PPNICILTEYCPRGSLQDILENESITLDWMFRYSLI 631

  Fly   718 HDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGLRTLTTPSDFVRDQNYYLKLLWIAP 782
            :||||||.:||||.:..||.|:|.||::|.||||||:|:||.:.....|......|:.|.||.:|
Frog   632 NDIVKGMLFLHNSVIVTHGNLKSSNCVVDSRFVLKITDYGLASFRCSPDSEDIHAYFAKKLWTSP 696

  Fly   783 ELLPLTTIPGCCPATQRGDVYSFGIILEEIVNRGGPYQEARQQMDVHTILHKVRQCNGFRPLIRE 847
            |||.:.|.|.  ..||:||||||||||:|:..|.|.:...........|:.:||...  :|:.
Frog   697 ELLRMETPPP--QGTQKGDVYSFGIILQEVALRNGVFYVDNADYSPKEIIERVRSRE--KPIF-- 755

  Fly   848 RECP------PDLLELMEKCWADNQEERPTFSTIRSNIRTIMKGFCENLMDDLLNRMEQYANNLE 906
            |.|.      .:|.:||::|||::..|||.|:.|:..:|...:....|::|:||:||||||||||
Frog   756 RPCTNLYCHIQELGQLMQRCWAEDPFERPEFNQIKVQLRKFNRESSTNILDNLLSRMEQYANNLE 820

  Fly   907 SLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSS 971
            .|||::|:....||::.|.|||||||..||:||..|:.|:.|.|.|||||||||||||.|.|.|:
Frog   821 ELVEDRTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAEST 885

  Fly   972 PMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSS 1036
            ||.||..|||||:.||.||..:||||||||||||:||||||..||..||||:|.|:|.:|.||.|
Frog   886 PMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREVARMSLALLDAVKS 950

  Fly  1037 FNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAI 1101
            |.:||:|..::::|||:|:|.|||||||.|||.||||||||||||||||.|:..|||||:||..:
Frog   951 FKIRHRPNQQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSTATHCV 1015

  Fly  1102 LDKFGTFQMEQRGDVELKGKGTVTTYWLNSTSEGE 1136
            |::|..|.:|.|||||:||||.|.||||    :||
Frog  1016 LEEFNCFVLELRGDVEMKGKGKVRTYWL----QGE 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	117/422 (28%)
		ANF_receptor	107..479	CDD:279440	111/400 (28%)
		PKc_like	616..885	CDD:304357	121/274 (44%)
		TyrKc	627..877	CDD:197581	117/255 (46%)
		HNOBA	<882..939	CDD:285003	30/56 (54%)
		CYCc	918..1109	CDD:214485	123/190 (65%)
		Guanylate_cyc	945..1131	CDD:278633	124/185 (67%)
npr1	XP_031747254.1	PBP1_NPR_A	27..434	CDD:380608	119/434 (27%)
		PK_GC-A_B	525..799	CDD:270944	123/284 (43%)
		HNOBA	<805..853	CDD:400168	29/47 (62%)
		CYCc	832..1017	CDD:214485	121/184 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	176	1.000	Domainoid score	I3559
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	1	1.000	-	-		FOG0002376
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010